产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
Ubiquityl-Histone H2A (Lys119) (D27C4) XP® Rabbit mAb
目录 :
8240
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
D27C4
反应物种 :
人类, 小鼠, 大鼠, fruit fly , 非洲爪蛙, 拟南芥
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, ChIP-Seq
文章摘录数: 62
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 图 2c
  • 免疫印迹; 人类; 1:100; 图 5e
Bakhoum M, Francis J, Agustinus A, Earlie E, Di Bona M, Abramson D, et al. Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression. Nat Commun. 2021;12:5402 pubmed 出版商
  • 免疫印迹; 人类; 1:1600; 图 6g
Maroni G, Bassal M, Krishnan I, Fhu C, Savova V, Zilionis R, et al. Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. Commun Biol. 2021;4:370 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Hanna R, Flamier A, Barabino A, Bernier G. G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer's disease. Nat Commun. 2021;12:1828 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:5000; 图 2b
  • 免疫印迹; 小鼠; 1:5000; 图 s5c
  • 免疫印迹; 人类; 1:5000; 图 s5g
Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020;11:3018 pubmed 出版商
  • ChIP-Seq; 非洲爪蛙; 图 3e
Kuznetsov J, Agüero T, Owens D, Kurtenbach S, Field M, Durante M, et al. BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers. Sci Adv. 2019;5:eaax1738 pubmed 出版商
  • ChIP-Seq; 小鼠; ; 图 s4a
Turberfield A, Kondo T, Nakayama M, Koseki Y, King H, Koseki H, et al. KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity. Nucleic Acids Res. 2019;47:9005-9023 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 4d
  • 免疫印迹; 人类; 1:1000; 图 3e
Azkanaz M, Rodríguez López A, de Boer B, Huiting W, Angrand P, Vellenga E, et al. Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock. elife. 2019;8: pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 s2a
Traynor S, Møllegaard N, Jørgensen M, Brückmann N, Pedersen C, Terp M, et al. Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins. Nucleic Acids Res. 2019;47:6668-6684 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 4p
  • 免疫组化-冰冻切片; 小鼠; 图 1a
Pivetti S, Fernandez Perez D, D Ambrosio A, Barbieri C, Manganaro D, Rossi A, et al. Loss of PRC1 activity in different stem cell compartments activates a common transcriptional program with cell type-dependent outcomes. Sci Adv. 2019;5:eaav1594 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 1f
  • 免疫印迹; 小鼠; 图 1d
Fursova N, Blackledge N, Nakayama M, Ito S, Koseki Y, Farcas A, et al. Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression. Mol Cell. 2019;74:1020-1036.e8 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 2f
  • 免疫印迹; 小鼠; 图 2a, 4d, s6f
He M, Chaurushiya M, Webster J, Kummerfeld S, Reja R, Chaudhuri S, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019;364:283-285 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 4b
  • 免疫印迹; 小鼠; 1:1000; 图 1b
Lavarone E, Barbieri C, Pasini D. Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity. Nat Commun. 2019;10:1679 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 3d
Kelly M, So J, Rogers A, Gregory G, Li J, Zethoven M, et al. Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis. Nat Commun. 2019;10:1347 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Chen X, Hu L, Yang H, Ma H, Ye K, Zhao C, et al. DHHC protein family targets different subsets of glioma stem cells in specific niches. J Exp Clin Cancer Res. 2019;38:25 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200; 图 s6d
Żylicz J, Bousard A, Zumer K, Dossin F, Mohammad E, da Rocha S, et al. The Implication of Early Chromatin Changes in X Chromosome Inactivation. Cell. 2019;176:182-197.e23 pubmed 出版商
  • 免疫印迹; 人类; 图 7b
Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20:1181-1192 pubmed 出版商
  • ChIP-Seq; 人类; 1:100; 图 6a
Ning B, Zhao W, Qian C, Liu P, Li Q, Li W, et al. USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components. Nat Commun. 2017;8:349 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 4e
  • 免疫印迹; 人类; 1:1000; 图 4a
Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:4263 pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Yan Y, Zhao W, Huang Y, Tong H, Xia Y, Jiang Q, et al. Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells. Sci Rep. 2017;7:46276 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 表 s3
Lau M, Schwartz M, Kundu S, Savol A, Wang P, Marr S, et al. Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science. 2017;355:1081-1084 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 5a
  • 免疫组化; 小鼠; 1:200
  • 免疫印迹; 小鼠; 图 5c
Jullien J, Vodnala M, Pasque V, Oikawa M, Miyamoto K, Allen G, et al. Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways. Mol Cell. 2017;65:873-884.e8 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Wheaton K, Sarkari F, Stanly Johns B, Davarinejad H, Egorova O, Kaustov L, et al. UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119. J Biol Chem. 2017;292:2893-2902 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 2
Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova T, et al. Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016;7:13661 pubmed 出版商
  • 染色质免疫沉淀 ; fruit fly ; 1:100; 图 s10d
  • 免疫组化; fruit fly ; 1:500; 图 s10b
Loubiere V, Delest A, Thomas A, Bonev B, Schuettengruber B, Sati S, et al. Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development. Nat Genet. 2016;48:1436-1442 pubmed 出版商
  • 染色质免疫沉淀 ; 拟南芥; 图 4
Li Z, Li B, Liu J, Guo Z, Liu Y, Li Y, et al. Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis. J Integr Plant Biol. 2016;58:959-970 pubmed 出版商
  • 染色质免疫沉淀 ; fruit fly ; 图 s14c
Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352:844-9 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 5
  • 免疫印迹; 小鼠; 图 5
Si S, Nakajima Takagi Y, Aoyama K, Oshima M, Saraya A, Sugishita H, et al. Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells. PLoS ONE. 2016;11:e0154561 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 st2
  • 免疫印迹; 小鼠; 图 s10
Stelloh C, Reimer M, Pulakanti K, Blinka S, Peterson J, Pinello L, et al. The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing. Epigenetics Chromatin. 2016;9:14 pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 图 1b
Eid A, Torres Padilla M. Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis. Epigenetics. 2016;11:389-97 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 6
García Prat L, Martínez Vicente M, Perdiguero E, Ortet L, Rodríguez Ubreva J, Rebollo E, et al. Autophagy maintains stemness by preventing senescence. Nature. 2016;529:37-42 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 3
  • 免疫组化; 小鼠; 1:400; 图 4
  • 免疫印迹; 小鼠; 1:5000; 图 2
Benitz S, Regel I, Reinhard T, Popp A, Schäffer I, Raulefs S, et al. Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells. Oncotarget. 2016;7:11424-33 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:200; 图 2
  • 染色质免疫沉淀 ; 小鼠; 图 2
Mardaryev A, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, et al. Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016;212:77-89 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Daou S, Hammond Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono N, et al. The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem. 2015;290:28643-63 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 s7
Papadakis A, Sun C, Knijnenburg T, Xue Y, Grernrum W, Hölzel M, et al. SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer. Cell Res. 2015;25:445-58 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 1a
  • 免疫印迹; 人类; 图 1i
Bhatnagar S, Gazin C, Chamberlain L, Ou J, Zhu X, Tushir J, et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature. 2014;516:116-20 pubmed 出版商
  • 免疫印迹; 人类
Hock A, Vigneron A, Vousden K. Ubiquitin-specific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity. J Biol Chem. 2014;289:34862-70 pubmed 出版商
  • 免疫印迹; 人类
Ji X, Lu H, Zhou Q, Luo K. LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. elife. 2014;3:e02907 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 1
  • 免疫印迹; 小鼠; 1:1000; 图 s1c
Cooper S, Dienstbier M, Hassan R, Schermelleh L, Sharif J, Blackledge N, et al. Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment. Cell Rep. 2014;7:1456-1470 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类; 1:1000
Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, et al. The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127 pubmed 出版商
  • 免疫沉淀; 人类
Yuan G, Ma B, Yuan W, Zhang Z, Chen P, Ding X, et al. Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases. J Biol Chem. 2013;288:30832-42 pubmed 出版商
  • 免疫印迹; 小鼠
Lee S, Phipson B, Hyland C, Leong H, Allan R, Lun A, et al. Polycomb repressive complex 2 (PRC2) suppresses E?-myc lymphoma. Blood. 2013;122:2654-63 pubmed 出版商
Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, et al. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. J Exp Med. 2020;217: pubmed 出版商
Tamburri S, Lavarone E, Fernandez Perez D, Conway E, Zanotti M, Manganaro D, et al. Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression. Mol Cell. 2019;: pubmed 出版商
Blackledge N, Fursova N, Kelley J, Huseyin M, Feldmann A, Klose R. PRC1 Catalytic Activity Is Central to Polycomb System Function. Mol Cell. 2019;: pubmed 出版商
Bianchi M, Crinelli R, Giacomini E, Carloni E, Radici L, Scarpa E, et al. A negative feedback mechanism links UBC gene expression to ubiquitin levels by affecting RNA splicing rather than transcription. Sci Rep. 2019;9:18556 pubmed 出版商
Healy E, Mucha M, Glancy E, Fitzpatrick D, Conway E, Neikes H, et al. PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation. Mol Cell. 2019;76:437-452.e6 pubmed 出版商
Lamb K, Bsteh D, Dishman S, Moussa H, Fan H, Stuckey J, et al. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019;26:1365-1379.e22 pubmed 出版商
de las Pozas A, Reiner T, De Cesare V, Trost M, Perez Stable C. Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells. Sci Rep. 2018;8:13146 pubmed 出版商
Nishioka K, Miyazaki H, Soejima H. Unbiased shRNA screening, using a combination of FACS and high-throughput sequencing, enables identification of novel modifiers of Polycomb silencing. Sci Rep. 2018;8:12128 pubmed 出版商
Dardalhon Cuménal D, Deraze J, Dupont C, Ribeiro V, Coléno Costes A, Pouch J, et al. Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability. PLoS Genet. 2018;14:e1007498 pubmed 出版商
Nagase R, Inoue D, Pastore A, Fujino T, Hou H, Yamasaki N, et al. Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation. J Exp Med. 2018;215:1729-1747 pubmed 出版商
Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, et al. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018;70:408-421.e8 pubmed 出版商
Kolluri K, Alifrangis C, Kumar N, Ishii Y, Price S, Michaut M, et al. Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. elife. 2018;7: pubmed 出版商
Omori Y, Kubo S, Kon T, Furuhashi M, Narita H, Kominami T, et al. Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity. Proc Natl Acad Sci U S A. 2017;114:E8264-E8273 pubmed 出版商
Dong Y, Isono K, Ohbo K, Endo T, Ohara O, Maekawa M, et al. EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice. Mol Cell Biol. 2017;37: pubmed 出版商
Endoh M, Endo T, Shinga J, Hayashi K, Farcas A, Ma K, et al. PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes. elife. 2017;6: pubmed 出版商
Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, et al. The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. J Biol Chem. 2015;290:4163-77 pubmed 出版商
Basnet H, Su X, Tan Y, Meisenhelder J, Merkurjev D, Ohgi K, et al. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. Nature. 2014;516:267-71 pubmed 出版商
Ji Z, Mohammed H, Webber A, Ridsdale J, Han N, Carroll J, et al. The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex. Nucleic Acids Res. 2014;42:6232-42 pubmed 出版商
Toth Z, Brulois K, Lee H, Izumiya Y, Tepper C, Kung H, et al. Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. PLoS Pathog. 2013;9:e1003813 pubmed 出版商
Adorno M, Sikandar S, Mitra S, Kuo A, Nicolis Di Robilant B, Haro Acosta V, et al. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature. 2013;501:380-4 pubmed 出版商
Endoh M, Endo T, Endoh T, Isono K, Sharif J, Ohara O, et al. Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet. 2012;8:e1002774 pubmed 出版商
产品信息
SKU号 :
8240P
产品名称 :
Ubiquityl-Histone H2A (Lys119) (D27C4) XP® Rabbit mAb
规格 :
40微升
Price-(USD) :
135美元
物种x :
H, M, R, Mk
应用 :
染色质免疫沉淀
产品种类 :
Chromatin Regulation / Nuclear Function
运输温度 :
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
23
宿主 :
靶标 :
H2A.4 (Lys120) ubiquitinate
最初蛋白 :
H2A.4
别名 :
H2A histone family, member R,H2A1A,H2AFR,HIST1H2AA,Histone H2A type 1-A,Histone H2A/r,bA317E16.2,histone 1, H2aa,histone cluster 1, H2aa
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。