产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
磷酸化FAK(Tyr397)(D20B1)兔单克隆抗体
目录 :
8556
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
D20B1
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
文章摘录数: 39
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 4c
Li P, Cao S, Huang Y, Zhang Y, Liu J, Cai X, et al. A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein. Cell Death Discov. 2021;7:198 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1n
Yin H, Wang J, Li H, Yu Y, Wang X, Lu L, et al. Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness. Nat Commun. 2021;12:4230 pubmed 出版商
  • 免疫印迹; 人类; 图 6d
Cheng X, Wang J, Liu C, Jiang T, Yang N, Liu D, et al. Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway. J Exp Clin Cancer Res. 2021;40:199 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Zhu J, Cai T, Zhou J, Du W, Zeng Y, Liu T, et al. CD151 drives cancer progression depending on integrin α3β1 through EGFR signaling in non-small cell lung cancer. J Exp Clin Cancer Res. 2021;40:192 pubmed 出版商
  • 免疫印迹; 人类; 图 4c, 4h
Qin X, Li J, Wang S, Lv J, Luan F, Liu Y, et al. Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Theranostics. 2021;11:6950-6965 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7g
Huang Y, Liang C, Ritz D, Coelho R, Septiadi D, Estermann M, et al. Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6a
Liu Y, Li L, Liu X, Wang Y, Liu L, Peng L, et al. Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling. elife. 2020;9: pubmed 出版商
  • 免疫细胞化学; 人类; 图 3d, 3f
  • 免疫印迹; 人类; 图 3a
Rigiracciolo D, Nohata N, Lappano R, Cirillo F, Talia M, Scordamaglia D, et al. IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6d
Yuan M, Xie F, Xia X, Zhong K, Lian L, Zhang S, et al. UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway. Int J Oncol. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2i, s5e
Kuninty P, Bansal R, de Geus S, Mardhian D, Schnittert J, van Baarlen J, et al. ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer. Sci Adv. 2019;5:eaax2770 pubmed 出版商
  • 免疫印迹; 人类; 图 3f
Liu Y, Wang X, Deng L, Ping L, Shi Y, Zheng W, et al. ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma. Cancer Cell Int. 2019;19:32 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 s3d
Mason D, Collins J, Dawahare J, Nguyen T, Lin Y, Voytik Harbin S, et al. YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility. J Cell Biol. 2019;218:1369-1389 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
de Jong O, van der Waals L, Kools F, Verhaar M, van Balkom B. Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition. J Cell Physiol. 2019;234:10260-10269 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Emori T, Hirose J, Ise K, Yomoda J, Kasahara M, Shinkuma T, et al. Constitutive Activation of Integrin ?9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis. J Immunol. 2017;199:3427-3436 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7a1
Shen C, Sun L, Zhu N, Qi F. Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing. Int J Mol Med. 2017;39:949-959 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 ev3b
Fallahi Sichani M, Becker V, Izar B, Baker G, Lin J, Boswell S, et al. Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state. Mol Syst Biol. 2017;13:905 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Wang Y, Chiang H, Huang Y, Hsu C, Yang P, Juan H, et al. A link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA. Cell Death Dis. 2016;7:e2458 pubmed 出版商
  • 免疫印迹; 人类; 图 8a
Zhang C, Wang H, Bao Q, Wang L, Guo T, Chen W, et al. NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction. Oncotarget. 2016;7:73593-73606 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4f
Cao R, Meng Z, Liu T, Wang G, Qian G, Cao T, et al. Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway. Oncotarget. 2016;7:72941-72960 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s7d
Rozo M, Li L, Fan C. Targeting ?1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice. Nat Med. 2016;22:889-96 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s4
  • 免疫印迹; 人类; 1:1000; 图 s6
Haemmerle M, Bottsford Miller J, Pradeep S, Taylor M, Choi H, Hansen J, et al. FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal. J Clin Invest. 2016;126:1885-96 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016;11:182-188 pubmed
  • 免疫印迹; 小鼠; 1:1000; 图 6
Zhang Y, Fan J, Ho J, Hu T, Kneeland S, Fan X, et al. Crim1 regulates integrin signaling in murine lens development. Development. 2016;143:356-66 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 1
Oudart J, Doué M, Vautrin A, Brassart B, Sellier C, Dupont Deshorgue A, et al. The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction. Oncotarget. 2016;7:1516-28 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
Kurozumi A, Goto Y, Matsushita R, Fukumoto I, Kato M, Nishikawa R, et al. Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. Cancer Sci. 2016;107:84-94 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 11
Sugiyama S, Yoshino Y, Kuriyama S, Inoue M, Komine K, Otsuka K, et al. A Curcumin Analog, GO-Y078, Effectively Inhibits Angiogenesis through Actin Disorganization. Anticancer Agents Med Chem. 2016;16:633-47 pubmed
  • 免疫细胞化学; 小鼠; 图 4
  • 免疫印迹; 小鼠; 图 4
Cáceres M, Ortiz L, Recabarren T, Romero A, Colombo A, Leiva Salcedo E, et al. TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. PLoS ONE. 2015;10:e0130540 pubmed 出版商
  • 免疫组化; 人类; 1:100
Sallam A, Mohyeldin M, Foudah A, Akl M, Nazzal S, Meyer S, et al. Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling. Org Biomol Chem. 2014;12:5295-303 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Elliott V, Rychahou P, Zaytseva Y, Evers B. Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model. PLoS ONE. 2014;9:e97432 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Dave J, Kang H, Abbey C, Maxwell S, Bayless K. Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). J Biol Chem. 2013;288:30720-33 pubmed 出版商
Ethaeb A, Mohammad M, Madkhali Y, Featherby S, Maraveyas A, Greenman J, et al. Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves β1-integrin signalling. Apoptosis. 2020;25:29-41 pubmed 出版商
Perri A, Agosti V, Olivo E, Concolino A, Angelis M, Tammè L, et al. Histone proteomics reveals novel post-translational modifications in breast cancer. Aging (Albany NY). 2019;11:11722-11755 pubmed 出版商
Mohan A, Dean K, Isogai T, Kasitinon S, Murali V, Roudot P, et al. Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. Dev Cell. 2019;49:444-460.e9 pubmed 出版商
Vornhagen J, Armistead B, Santana Ufret V, Gendrin C, Merillat S, Coleman M, et al. Group B streptococcus exploits vaginal epithelial exfoliation for ascending infection. J Clin Invest. 2018;128:1985-1999 pubmed 出版商
Cook J, Ueno N, Lodoen M. Toxoplasma gondii disrupts β1 integrin signaling and focal adhesion formation during monocyte hypermotility. J Biol Chem. 2018;293:3374-3385 pubmed 出版商
Feng Y, Jin D, Sokol E, Reinhardt F, Miller D, Gupta P. Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1. Nat Commun. 2017;8:1079 pubmed 出版商
Fan Y, Qu X, Ma Y, Liu Y, Hu X. Cbl-b promotes cell detachment via ubiquitination of focal adhesion kinase. Oncol Lett. 2016;12:1113-1118 pubmed
Kang W, Kim S, Cho H, Jin J, Lee J, Joo K, et al. Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme. Oncotarget. 2015;6:27239-51 pubmed 出版商
Zhuo B, Wang R, Zhang H, Qin H, Yin Y, Shi Y. Interleukin-24 inhibits cell migration and invasion in the neuroblastoma cell line SH-SY5Y. Oncol Rep. 2013;30:2749-54 pubmed 出版商
产品信息
SKU号 :
8556S
产品名称 :
磷酸化FAK(Tyr397)(D20B1)兔单克隆抗体
规格 :
100微升
Price-(USD) :
274美元
物种x :
H, (M, R, Mk)
应用 :
免疫沉淀
产品种类 :
粘连/ECM
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
125
宿主 :
靶标 :
FAK(Tyr397)磷酸盐
最初蛋白 :
FAK
别名 :
FADK,FADK 1,FAK,FAK-related non-kinase polypeptide,FAK1,FRNK,Focal adhesion kinase 1,PTK2,PTK2 protein tyrosine kinase 2,Protein-tyrosine kinase 2,pp125FAK
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。