产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
溶酶体相关膜蛋白质1(D2D11)XP®兔单克隆抗体
目录 :
9091
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
D2D11
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, proximity ligation assay
文章摘录数: 72
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 4b
Zhao J, Lu W, Ren Y, Fu Y, Martens Y, Shue F, et al. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids. Acta Neuropathol. 2021;142:807-825 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4d
Zhang Y, Chen Y, Li Y, Huang F, Luo B, Yuan Y, et al. The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι. Proc Natl Acad Sci U S A. 2021;118: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6b
Li Y, Chen L, Li L, Sottas C, Petrillo S, Lazaris A, et al. Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease. iScience. 2021;24:102457 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4a
Zang R, Case J, Yutuc E, Ma X, Shen S, Gomez Castro M, et al. Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proc Natl Acad Sci U S A. 2020;117:32105-32113 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 1e
Hall Roberts H, Agarwal D, Obst J, Smith T, Monzón Sandoval J, Di Daniel E, et al. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimers Res Ther. 2020;12:151 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4b
Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 1b
Yamamoto K, Venida A, Yano J, Biancur D, Kakiuchi M, Gupta S, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020;581:100-105 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1
Deng M, Chen Z, Tan J, Liu H. Down-regulation of SLC35C1 induces colon cancer through over-activating Wnt pathway. J Cell Mol Med. 2020;24:3079-3090 pubmed 出版商
  • 免疫印迹; 人类; 图 6c
Laflamme C, McKeever P, Kumar R, Schwartz J, Kolahdouzan M, Chen C, et al. Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 1:3000; 图 4c
Riessland M, Kolisnyk B, Kim T, Cheng J, Ni J, Pearson J, et al. Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. Cell Stem Cell. 2019;25:514-530.e8 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 s3h
Höglinger D, Burgoyne T, Sanchez Heras E, Hartwig P, Colaco A, Newton J, et al. NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress. Nat Commun. 2019;10:4276 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1d
Son S, Park S, Lee H, Siddiqi F, Lee J, Menzies F, et al. Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Cell Metab. 2019;29:192-201.e7 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Nnah I, Wang B, Saqcena C, Weber G, Bonder E, Bagley D, et al. TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy. Autophagy. 2019;15:151-164 pubmed 出版商
  • proximity ligation assay; 人类; 1:200; 图 5e
Atakpa P, Thillaiappan N, Mataragka S, Prole D, Taylor C. IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes. Cell Rep. 2018;25:3180-3193.e7 pubmed 出版商
  • 免疫组化; 人类; 图 3a
Messenger S, Woo S, Sun Z, Martin T. A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4. J Cell Biol. 2018;217:2877-2890 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 2d
Laviolette L, Mermoud J, Calvo I, Olson N, Boukhali M, Steinlein O, et al. Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein. Nat Commun. 2017;8:15866 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 3c
Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, O Prey J, Clark W, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell. 2017;66:517-532.e9 pubmed 出版商
  • 免疫印迹; 人类; 图 s10a
Suresh S, Chavalmane A, Dj V, Yarreiphang H, Rai S, Paul A, et al. A novel autophagy modulator 6-Bio ameliorates SNCA/?-synuclein toxicity. Autophagy. 2017;13:1221-1234 pubmed 出版商
  • 免疫组化; 人类; 图 4
Ghadially H, Brown L, Lloyd C, Lewis L, LEWIS A, Dillon J, et al. MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue. Br J Cancer. 2017;116:1208-1217 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 7a
Sanger A, Yip Y, Randall T, Pernigo S, Steiner R, Dodding M. SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. J Cell Sci. 2017;130:1637-1651 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4c
Varadaraj A, JENKINS L, Singh P, Chanda A, Snider J, Lee N, et al. TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism. Mol Biol Cell. 2017;28:1195-1207 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s5a
Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed 出版商
  • 流式细胞仪; 人类; 图 6a
Prasad A, Kulkarni R, Jiang S, Groopman J. Cocaine Enhances DC to T-cell HIV-1 Transmission by Activating DC-SIGN/LARG/LSP1 Complex and Facilitating Infectious Synapse Formation. Sci Rep. 2017;7:40648 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2c
Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1e
Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J, Monteleone E, et al. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Nature. 2017;541:228-232 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 4c
Song H, Chiang H, Tseng W, Wu P, Chien C, Leu H, et al. Using CRISPR/Cas9-Mediated GLA Gene Knockout as an In Vitro Drug Screening Model for Fabry Disease. Int J Mol Sci. 2016;17: pubmed
  • 免疫细胞化学; 人类; 图 5
Assadi G, Vesterlund L, Bonfiglio F, Mazzurana L, Cordeddu L, Schepis D, et al. Functional Analyses of the Crohn's Disease Risk Gene LACC1. PLoS ONE. 2016;11:e0168276 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 3a
  • 免疫印迹; 人类; 图 1c
Shi B, Huang Q, Birkett R, Doyle R, Dorfleutner A, Stehlik C, et al. SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy. 2017;13:285-301 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1b
Sambri I, D Alessio R, Ezhova Y, Giuliano T, Sorrentino N, Cacace V, et al. Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases. EMBO Mol Med. 2017;9:112-132 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Weikel K, Cacicedo J, Ruderman N, Ido Y. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016;36: pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Huang L, Stuart C, Takeda K, D Agnillo F, Golding B. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS ONE. 2016;11:e0160875 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3
Want A, Gillespie S, Wang Z, Gordon R, Iomini C, Ritch R, et al. Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients. PLoS ONE. 2016;11:e0157404 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Kuramoto K, Wang N, Fan Y, Zhang W, Schoenen F, Frankowski K, et al. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. 2016;12:1460-71 pubmed 出版商
  • 免疫组化; 人类; 1:1000; 图 4a
  • 免疫印迹; 人类; 1:2000; 图 7b
Okato A, Goto Y, Kurozumi A, Kato M, Kojima S, Matsushita R, et al. Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer. Int J Oncol. 2016;49:111-22 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Pastore N, Brady O, Diab H, Martina J, Sun L, Huynh T, et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy. 2016;12:1240-58 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s1a
Starling G, Yip Y, Sanger A, Morton P, Eden E, Dodding M. Folliculin directs the formation of a Rab34-RILP complex to control the nutrient-dependent dynamic distribution of lysosomes. EMBO Rep. 2016;17:823-41 pubmed 出版商
  • 免疫细胞化学; 人类; 1:400; 图 6
Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Zou M, Zhu W, Wang L, Shi L, Gao R, Ou Y, et al. AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition. Oncotarget. 2016;7:13122-38 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Laura R, Dong D, Reynolds W, Maki R. T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys319 in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond Formation. PLoS ONE. 2016;11:e0149391 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s1a
Chung V, Tan T, Tan M, Wong M, Kuay K, Yang Z, et al. GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification. Sci Rep. 2016;6:19943 pubmed 出版商
  • 免疫细胞化学; 人类; 图 6
Hayashi H, Al Mamun A, Sakima M, Sato M. Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing during angiogenesis. J Cell Sci. 2016;129:1210-22 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 3
  • 免疫印迹; 人类; 1:1000; 图 3
Button R, Vincent J, Strang C, Luo S. Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis. Oncotarget. 2016;7:5157-75 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Lao Y, Xu N. Autophagy in Cancer Chemoprevention: Identification of Novel Autophagy Modulators with Anticancer Potential. Methods Mol Biol. 2016;1379:151-63 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 5
  • 免疫印迹; 人类; 图 4
Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2n
Selleck E, Orchard R, Lassen K, Beatty W, Xavier R, Levine B, et al. A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells. MBio. 2015;6:e01157-15 pubmed 出版商
  • 免疫印迹; 人类; 图 7g
Nezich C, Wang C, Fogel A, Youle R. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015;210:435-50 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Hirata T, Fujita M, Nakamura S, Gotoh K, Motooka D, Murakami Y, et al. Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport. Mol Biol Cell. 2015;26:3071-84 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3
Bradley S, Chen Z, Melendez B, Talukder A, Khalili J, Rodríguez Cruz T, et al. BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma. Cancer Immunol Res. 2015;3:602-9 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
  • 免疫印迹; 人类
Yang N, Tan S, Ng S, Shi Y, Zhou J, Tan K, et al. Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem. 2014;289:33425-41 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Bauckman K, Haller E, Flores I, Nanjundan M. Iron modulates cell survival in a Ras- and MAPK-dependent manner in ovarian cells. Cell Death Dis. 2013;4:e592 pubmed 出版商
Saini H, Sharma H, Mukherjee S, Chowdhury S, Chowdhury R. Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells. Cancer Cell Int. 2021;21:52 pubmed 出版商
Jones S, King P, Antonescu C, Sugiyama M, Bhamra A, Surinova S, et al. Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation. Sci Rep. 2020;10:663 pubmed 出版商
Jia J, Claude Taupin A, Gu Y, Choi S, Peters R, Bissa B, et al. Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal. Dev Cell. 2019;: pubmed 出版商
Ruzickova E, Skoupa N, Dolezel P, Smith D, Mlejnek P. The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance. Biomolecules. 2019;9: pubmed 出版商
Barroso González J, García Expósito L, Hoang S, Lynskey M, Roncaioli J, Ghosh A, et al. RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Mol Cell. 2019;76:11-26.e7 pubmed 出版商
Datta G, Miller N, Afghah Z, Geiger J, Chen X. HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells. Front Cell Neurosci. 2019;13:329 pubmed 出版商
White S, Avantaggiati M, Nemazanyy I, Di Poto C, Yang Y, Pende M, et al. YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells. Dev Cell. 2019;49:425-443.e9 pubmed 出版商
Servián Morilla E, Cabrera Serrano M, Rivas Infante E, Carvajal A, Lamont P, Pelayo Negro A, et al. Altered myogenesis and premature senescence underlie human TRIM32-related myopathy. Acta Neuropathol Commun. 2019;7:30 pubmed 出版商
Sakai R, Fukuda R, Unida S, Aki M, Ono Y, Endo A, et al. The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors. J Cell Sci. 2019;132: pubmed 出版商
Surve M, Bhutda S, Datey A, Anil A, Rawat S, Pushpakaran A, et al. Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking. PLoS Pathog. 2018;14:e1007168 pubmed 出版商
Sun W, Yue J. TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells. Exp Cell Res. 2018;370:478-489 pubmed 出版商
Fuchs R, Stracke A, Holzmann V, Luschin Ebengreuth G, Meier Allard N, Ebner N, et al. Prazosin induced lysosomal tubulation interferes with cytokinesis and the endocytic sorting of the tumour antigen CD98hc. Biochim Biophys Acta Mol Cell Res. 2018;1865:1211-1229 pubmed 出版商
Kramer N, Haney M, Morgens D, Jovicic A, Couthouis J, Li A, et al. CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. Nat Genet. 2018;50:603-612 pubmed 出版商
Fu R, Deng Q, Zhang H, Hu X, Li Y, Liu Y, et al. A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3. Cell Death Dis. 2018;9:243 pubmed 出版商
Wu Y, Guo X, Kanemoto S, Maeoka Y, Saito A, Asada R, et al. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. PLoS ONE. 2018;13:e0190407 pubmed 出版商
Bosse K, Raman P, Zhu Z, Lane M, Martinez D, Heitzeneder S, et al. Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Cancer Cell. 2017;32:295-309.e12 pubmed 出版商
Zhang C, Lai M, Khandan L, Lee L, Chen Z, Junge H. Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function. Nat Commun. 2017;8:16050 pubmed 出版商
Gomarasca M, F C Martins T, Greune L, Hardwidge P, Schmidt M, Rüter C. Bacterium-Derived Cell-Penetrating Peptides Deliver Gentamicin To Kill Intracellular Pathogens. Antimicrob Agents Chemother. 2017;61: pubmed 出版商
Sherbenou D, Aftab B, Su Y, Behrens C, Wiita A, Logan A, et al. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016;126:4640-4653 pubmed 出版商
Zhang J, Wang J, Xu J, Lu Y, Jiang J, Wang L, et al. Curcumin targets the TFEB-lysosome pathway for induction of autophagy. Oncotarget. 2016;7:75659-75671 pubmed 出版商
Moruno Manchon J, Uzor N, DABAGHIAN Y, Furr Stimming E, Finkbeiner S, Tsvetkov A. Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy. Sci Rep. 2015;5:15213 pubmed 出版商
Lao Y, Wan G, Liu Z, Wang X, Ruan P, Xu W, et al. The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation. Autophagy. 2014;10:736-49 pubmed 出版商
产品信息
SKU号 :
9091P
产品名称 :
溶酶体相关膜蛋白质1(D2D11)XP®兔单克隆抗体
规格 :
40微升
Price-(USD) :
135美元
物种x :
H, R, Mk
应用 :
免疫荧光(免疫细胞化学)
产品种类 :
Cytoskeletal Signaling
运输温度 :
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
42 (non-glycosylated), 90-120 (glycosylated)
宿主 :
靶标 :
溶酶体相关膜蛋白质1
最初蛋白 :
溶酶体相关膜蛋白质1
别名 :
CD107 antigen-like family member A,CD107a,LAMP-1,LAMP1,LAMPA,LGP120,Lysosome-associated membrane glycoprotein 1,Lysosome-associated membrane protein 1,lysosomal-associated membrane protein 1
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。