产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
MEK1/2(47E6)兔单克隆抗体
目录 :
9126
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
47E6
反应物种 :
仓鼠, 人类, 小鼠, 大鼠
应用 :
免疫印迹
文章摘录数: 33
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 6b
Yang X, Jiang J, Zhang C, Li Y. Baicalein restrains proliferation, migration, and invasion of human malignant melanoma cells by down-regulating colon cancer associated transcript-1. Braz J Med Biol Res. 2019;52:e8934 pubmed 出版商
  • 免疫印迹; 人类; 图 s3e
Pan C, Jin L, Wang X, Li Y, Chun J, Boese A, et al. Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest. 2019;129:2431-2445 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2b
Diamond E, Durham B, Ulaner G, Drill E, Buthorn J, Ki M, et al. Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019;567:521-524 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
  • 免疫印迹; 小鼠; 图 1h
Stivala S, Codilupi T, Brkic S, Baerenwaldt A, Ghosh N, Hao Shen H, et al. Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms. J Clin Invest. 2019;130:1596-1611 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4a
Yang X, Qi L, Lin F, Ou Z. The role of the chemokine receptor XCR1 in breast cancer cells. Breast Cancer (Dove Med Press). 2017;9:227-236 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, et al. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. J Biol Chem. 2017;292:7866-7887 pubmed 出版商
  • 免疫印迹; 人类; 图 6d
Spencer Smith R, Koide A, Zhou Y, Eguchi R, Sha F, Gajwani P, et al. Inhibition of RAS function through targeting an allosteric regulatory site. Nat Chem Biol. 2017;13:62-68 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 4a
Ye Y, Zhao Z, Xu H, Zhang X, Su X, Yang Y, et al. Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway. Neural Plast. 2016;2016:8072156 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 s6
Mair B, Konopka T, Kerzendorfer C, Sleiman K, Salic S, Serra V, et al. Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity. PLoS Genet. 2016;12:e1006279 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed
  • 免疫印迹; 小鼠; 图 s2
Lim S, Yuzhalin A, Gordon Weeks A, Muschel R. Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells. Oncogene. 2016;35:5735-5745 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Zwang N, Zhang R, Germana S, Fan M, Hastings W, Cao A, et al. Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways. Am J Transplant. 2016;16:2624-38 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7
Woodfield S, Guo R, Liu Y, Major A, Hollingsworth E, Indiviglio S, et al. Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B. Genes Cancer. 2016;7:13-26 pubmed
  • 免疫印迹; 人类; 图 3b
Bigenzahn J, Fauster A, Rebsamen M, Kandasamy R, Scorzoni S, Vladimer G, et al. An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client. Mol Cell Proteomics. 2016;15:1139-50 pubmed
  • 免疫印迹; 人类; 图 1
Woodfield S, Zhang L, Scorsone K, Liu Y, Zage P. Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression. BMC Cancer. 2016;16:172 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 2
Bhargava A, Pelech S, Woodard B, Kerwin J, Maherali N. Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 人类; 图 1
Chung S, Moon H, Ju H, Kim D, Cho K, Ribback S, et al. Comparison of liver oncogenic potential among human RAS isoforms. Oncotarget. 2016;7:7354-66 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Wandinger S, Lahortiga I, Jacobs K, Klammer M, Jordan N, Elschenbroich S, et al. Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling. PLoS ONE. 2016;11:e0146100 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 4a
Gruosso T, Garnier C, Abélanet S, Kieffer Y, Lemesre V, Bellanger D, et al. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun. 2015;6:8583 pubmed 出版商
  • 免疫印迹; 仓鼠; 图 5s1d
Å olman M, Ligabue A, BlaževitÅ¡ O, Jaiswal A, Zhou Y, Liang H, et al. Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation. elife. 2015;4:e08905 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Hutchinson K, Johnson D, Johnson A, Sanchez V, Kuba M, Lu P, et al. ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma. Oncotarget. 2015;6:22348-60 pubmed
  • 免疫印迹; 小鼠; 1:500; 图 6g
Yang Z, Zheng B, Zhang Y, He M, Zhang X, Ma D, et al. miR-155-dependent regulation of mammalian sterile 20-like kinase 2 (MST2) coordinates inflammation, oxidative stress and proliferation in vascular smooth muscle cells. Biochim Biophys Acta. 2015;1852:1477-89 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Silva G, Aboussekhra A. p16(INK4A) inhibits the pro-metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF-β1. Mol Carcinog. 2016;55:525-36 pubmed 出版商
Du M, Zhang L, Scorsone K, Woodfield S, Zage P. Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine. Sci Rep. 2016;6:27458 pubmed 出版商
Lakshmanan A, Scarberry D, Green J, Zhang X, Selmi Ruby S, Jhiang S. Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin. Oncotarget. 2015;6:31792-804 pubmed 出版商
Bigatto V, De Bacco F, Casanova E, Reato G, Lanzetti L, Isella C, et al. TNF-α promotes invasive growth through the MET signaling pathway. Mol Oncol. 2015;9:377-88 pubmed 出版商
Hughes A, Spelke D, Xu Z, Kang C, Schaffer D, Herr A. Single-cell western blotting. Nat Methods. 2014;11:749-55 pubmed 出版商
Sandy A, Chung J, Toubai T, Shan G, Tran I, Friedman A, et al. T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells. J Immunol. 2013;190:5818-28 pubmed 出版商
Guo L, Chen C, Liang Q, Karim M, Gorska M, Alam R. Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor. J Immunol. 2013;190:159-67 pubmed 出版商
Cayer M, Samson M, Bertrand C, Dumont N, Drouin M, Jung D. Suppression of protein phosphatase 2A activity enhances Ad5/F35 adenovirus transduction efficiency in normal human B lymphocytes and in Raji cells. J Immunol Methods. 2012;376:113-24 pubmed 出版商
Weisberg E, Ray A, Nelson E, Adamia S, Barrett R, Sattler M, et al. Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells. PLoS ONE. 2011;6:e25351 pubmed 出版商
Wu L, Pfeiffer D, Calhoon E, Madiai F, Marcucci G, Liu S, et al. Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen. J Biol Chem. 2011;286:24916-30 pubmed 出版商
Caunt C, McArdle C. Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions. J Cell Sci. 2010;123:4310-20 pubmed 出版商
产品信息
SKU号 :
9126S
产品名称 :
MEK1/2(47E6)兔单克隆抗体
规格 :
100微升
Price-(USD) :
235美元
物种x :
H, M, R, Mk, (Dg)
应用 :
免疫印迹
产品种类 :
MAP Kinase Signaling
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
45
宿主 :
靶标 :
MEK1/MEK2
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。