产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
磷酸化信号传导子及转录激活子1(Tyr701)(58D6)兔单克隆抗体
目录 :
9167
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
58D6
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, mass cytometry, 免疫印迹基因敲除验证
文章摘录数: 112
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 3h
  • 免疫印迹; 人类; 1:1000; 图 3g, 3i
Xu P, Xiong W, Lin Y, Fan L, Pan H, Li Y. Histone deacetylase 2 knockout suppresses immune escape of triple-negative breast cancer cells via downregulating PD-L1 expression. Cell Death Dis. 2021;12:779 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 3b
  • 免疫细胞化学; 人类; 图 1j
Bruand M, Barras D, Mina M, Ghisoni E, Morotti M, Lanitis E, et al. Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. Cell Rep. 2021;36:109412 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Hering L, Katkeviciute E, Schwarzfischer M, Niechcial A, Riggs J, Wawrzyniak M, et al. Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis. Int J Mol Sci. 2021;22: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s5a
Atcha H, Jairaman A, Holt J, Meli V, Nagalla R, Veerasubramanian P, et al. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021;12:3256 pubmed 出版商
  • 免疫组化; 小鼠; 图 7a
Shang L, Ren H, Wang S, Liu H, Hu A, Gou P, et al. SS-31 Protects Liver from Ischemia-Reperfusion Injury via Modulating Macrophage Polarization. Oxid Med Cell Longev. 2021;2021:6662156 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 5d
McElrath C, Espinosa V, Lin J, Peng J, Sridhar R, Dutta O, et al. Critical role of interferons in gastrointestinal injury repair. Nat Commun. 2021;12:2624 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6d
Gangoso E, Southgate B, Bradley L, Rus S, Gálvez Cancino F, McGivern N, et al. Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion. Cell. 2021;184:2454-2470.e26 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s3d
Shang M, Yang H, Yang R, Chen T, Fu Y, Li Y, et al. The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation. Nat Commun. 2021;12:1940 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4g
Arenas E, Martínez Sabadell A, Rius Ruiz I, Román Alonso M, Escorihuela M, Luque A, et al. Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Nat Commun. 2021;12:1237 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 5g
  • 免疫印迹; 小鼠; 0.2 ug/ml; 图 4h
Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021;371: pubmed 出版商
  • 免疫印迹; 人类
Liao T, Lin C, Jiang J, Yang S, Teng H, Yang M. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. Theranostics. 2020;10:6095-6112 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1c
Liu X, Kong W, Peterson C, McGrail D, Hoang A, Zhang X, et al. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020;11:2135 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Wang Bishop L, Wehbe M, Shae D, James J, Hacker B, Garland K, et al. Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma. J Immunother Cancer. 2020;8: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2h
Weindel C, Bell S, Vail K, West K, Patrick K, Watson R. LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis. elife. 2020;9: pubmed 出版商
  • 免疫组化; 小鼠; 图 4d
  • 免疫印迹; 小鼠; 图 4b
Xiang S, Chen K, Xu L, Wang T, Guo C. Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Des Devel Ther. 2020;14:129-143 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 8a
  • 免疫印迹; 小鼠; 1:1000; 图 3a
Mosaheb M, Dobrikova E, Brown M, Yang Y, Cable J, Okada H, et al. Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity. Nat Commun. 2020;11:524 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Lohard S, Bourgeois N, Maillet L, Gautier F, Fétiveau A, Lasla H, et al. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Nat Commun. 2020;11:259 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s6c
Kim J, Gupta R, Blanco L, Yang S, Shteinfer Kuzmine A, Wang K, et al. VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease. Science. 2019;366:1531-1536 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Thiem A, Hesbacher S, Kneitz H, di Primio T, Heppt M, Hermanns H, et al. IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression. J Exp Clin Cancer Res. 2019;38:397 pubmed 出版商
  • 免疫印迹; 人类; 图 4b
Pech M, Fong L, Villalta J, Chan L, Kharbanda S, O Brien J, et al. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 图 s4f
Liu Y, You Y, Lu Z, Yang J, Li P, Liu L, et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. Science. 2019;365:1171-1176 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3s1e
Park M, Kim A, Manandhar S, Oh S, Jang G, Kang L, et al. CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 图 s3b
Joyce M, Berry Wynne K, Dos Santos T, Addison W, McFarlane N, Hobman T, et al. HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response. PLoS Pathog. 2019;15:e1007949 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5d
Reisländer T, Lombardi E, Groelly F, Miar A, Porru M, Di Vito S, et al. BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors. Nat Commun. 2019;10:3143 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 4f
von Gamm M, Schaub A, Jones A, Wolf C, Behrens G, Lichti J, et al. Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. J Exp Med. 2019;: pubmed 出版商
  • mass cytometry; 人类; 图 s1
Fernandez I, Baxter R, Garcia Perez J, Vendrame E, Ranganath T, Kong D, et al. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019;216:1255-1267 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 s1a
  • 免疫印迹; 小鼠; 图 1b
Wang E, Dai Z, Ferrante A, Drake C, Christiano A. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Sakahara M, Okamoto T, Oyanagi J, Takano H, Natsume Y, Yamanaka H, et al. IFN/STAT signaling controls tumorigenesis and the drug response in colorectal cancer. Cancer Sci. 2019;110:1293-1305 pubmed 出版商
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Martin V, Chiriaco C, Modica C, Acquadro A, Cortese M, Galimi F, et al. Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours. Br J Cancer. 2019;120:527-536 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3e
Mastroianni J, Stickel N, Andrlova H, Hanke K, Melchinger W, Duquesne S, et al. miR-146a Controls Immune Response in the Melanoma Microenvironment. Cancer Res. 2019;79:183-195 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3d
Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Lee E, Ouzounova M, Piranlioglu R, Ma M, Guzel M, Marasco D, et al. The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20. Oncogene. 2019;38:469-482 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s5c
Izumi T, Imai J, Yamamoto J, Kawana Y, Endo A, Sugawara H, et al. Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation. Nat Commun. 2018;9:5300 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4a
Qin L, Min W, Xin S. AIP1 suppresses transplant arteriosclerosis through inhibition of vascular smooth muscle cell inflammatory response to IFNγ. Anat Rec (Hoboken). 2018;: pubmed 出版商
  • 免疫印迹; 人类; 图 1d
  • 免疫组化-石蜡切片; 小鼠; 图 4g
  • 免疫印迹; 小鼠; 图 1c, 4f
Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1d
  • 免疫印迹; 人类; 图 4a
Sarkar M, Hile G, Tsoi L, Xing X, Liu J, Liang Y, et al. Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa. Ann Rheum Dis. 2018;77:1653-1664 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s1g
Zhang C, Wang C, Jiang M, Gu C, Xiao J, Chen X, et al. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun. 2018;9:2745 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s11a
Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6d
Xi J, Huang Q, Wang L, Ma X, Deng Q, Kumar M, et al. miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. Oncogene. 2018;37:3151-3165 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Taylor J, Cash M, Santostefano K, Nakanishi M, Terada N, Wallet M. CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages. J Leukoc Biol. 2018;: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s7a
Hsieh W, Hsu T, Chang Y, Lai M. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. 2018;9:463 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4b
Chiang C, Pauli E, Biryukov J, Feister K, Meng M, White E, et al. The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling. J Virol. 2018;92: pubmed 出版商
  • 免疫印迹; 小鼠; 图 6a
  • 免疫组化-石蜡切片; 人类; 1:800; 图 1a
  • 免疫印迹; 人类; 图 s8k
Wang W, Wang Y, Qu C, Wang S, Zhou J, Cao W, et al. The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response. Hepatology. 2018;67:2096-2112 pubmed 出版商
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Stav Noraas T, Edelmann R, Poulsen L, Sundnes O, Phung D, Küchler A, et al. Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery. J Immunol. 2017;198:3318-3325 pubmed 出版商
  • 免疫印迹; 人类; 图 5d
Cayrol F, Praditsuktavorn P, Fernando T, Kwiatkowski N, Marullo R, Calvo Vidal M, et al. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors. Nat Commun. 2017;8:14290 pubmed 出版商
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Xue N, Zhou Q, Ji M, Jin J, Lai F, Chen J, et al. Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype. Sci Rep. 2017;7:39011 pubmed 出版商
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  • 免疫印迹; 人类; 图 5d
Ma W, Tummers B, van Esch E, Goedemans R, Melief C, Meyers C, et al. Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFN?- and TNF?-Mediated Antiproliferative Effects and Necroptosis. Front Immunol. 2016;7:496 pubmed
  • 免疫印迹; 人类; 图 5a
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Kim J, Weeratunga P, Kim M, Nikapitiya C, Lee B, Uddin M, et al. Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med. 2016;16:265 pubmed 出版商
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Sharma N, Kumawat K, Rastogi M, Basu A, Singh S. Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5. Sci Rep. 2016;6:27685 pubmed 出版商
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Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed 出版商
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Cant Barrett K, Spijkers Hagelstein J, Buijs Gladdines J, Uitdehaag J, Smits W, van der Zwet J, et al. MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia. Leukemia. 2016;30:1832-43 pubmed 出版商
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Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, et al. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science. 2016;352:1232-6 pubmed 出版商
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Anghelina D, Lam E, Falck Pedersen E. Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. J Virol. 2016;90:5915-27 pubmed 出版商
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Wang Z, Ji J, Peng D, Ma F, Cheng G, Qin F. Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System. J Immunol. 2016;196:4322-30 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Slørdahl T, Abdollahi P, Vandsemb E, Rampa C, Misund K, Baranowska K, et al. The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells. Oncotarget. 2016;7:27295-306 pubmed 出版商
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Li J, Chen K, Li S, Liu T, Wang F, Xia Y, et al. Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis. PLoS ONE. 2016;11:e0152570 pubmed 出版商
  • 免疫组化; 人类; 1:50; 表 2
Menter T, Dickenmann M, Juskevicius D, Steiger J, Dirnhofer S, Tzankov A. Comprehensive phenotypic characterization of PTLD reveals potential reliance on EBV or NF-κB signalling instead of B-cell receptor signalling. Hematol Oncol. 2017;35:187-197 pubmed 出版商
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Wang J, De Veirman K, De Beule N, Maes K, De Bruyne E, Van Valckenborgh E, et al. The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells. Oncotarget. 2015;6:43992-4004 pubmed 出版商
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Kraut B, Maier H, Kókai E, Fiedler K, Boettger T, Illing A, et al. Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality. PLoS ONE. 2015;10:e0141591 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 9e
Herz J, Johnson K, McGavern D. Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells. J Exp Med. 2015;212:1153-69 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Wang S, Zheng G, Zhao L, Xu F, Qian J. Shp-2 contributes to anti-RSV activity in human pulmonary alveolar epithelial cells by interfering with the IFN-α-induced Jak/Stat1 pathway. J Cell Mol Med. 2015;19:2432-40 pubmed 出版商
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Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, et al. An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS ONE. 2015;10:e0126159 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 1:80; 图 8a
  • 流式细胞仪; 人类; 1:200; 图 6a
  • 免疫印迹; 人类; 1:1000; 图 6b
Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, et al. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576 pubmed 出版商
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Radhakrishnan V, Kojs P, Ramalingam R, Midura Kiela M, Angeli P, Kiela P, et al. Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules. J Biol Chem. 2015;290:8964-74 pubmed 出版商
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产品信息
SKU号 :
9167S
产品名称 :
磷酸化信号传导子及转录激活子1(Tyr701)(58D6)兔单克隆抗体
规格 :
100微升
Price-(USD) :
274美元
物种x :
H, M
应用 :
染色质免疫沉淀
产品种类 :
免疫学和炎症
运输温度 :
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
84, 91
宿主 :
靶标 :
信号传导子及转录激活子1(Tyr701)磷酸盐
最初蛋白 :
信号传导子及转录激活子1
别名 :
DKFZp686B04100,ISGF-3,STAT1,STAT91,Signal transducer and activator of transcription 1-alpha/beta,Transcription factor ISGF-3 components p91/p84,signal transducer and activator of transcription 1, 91kDa,signal transducer and activator of transcription-1
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。