公司名称 :
产品类型 :
产品名称 :
Phospho-Akt (Ser473) Antibody
目录 :
克隆性 :
宿主 :
domestic rabbit
共轭标签 :
抗原修饰 :
反应物种 :
人类, 小鼠, 大鼠, , , pigs , 斑马鱼, 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, reverse phase protein lysate microarray, 其他
文章摘录数: 371
  • 免疫印迹; 小鼠; 1:1000; 图 3d
Au C, Furness J, Britt K, Oshchepkova S, Ladumor H, Soo K, et al. Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 图 2s2c
Marmol P, Krapacher F, Ibanez C. Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 图 1h
Ruiz Velasco A, Zi M, Hille S, Azam T, Kaur N, Jiang J, et al. Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3a
Huang C, Lu S, Huang T, Huang B, Sun H, Yang S, et al. FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells. Theranostics. 2020;10:2817-2831 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:2000; 图 8h
  • 免疫印迹; 小鼠; 1:200; 图 8a
Alshehri B, Pagnin M, Lee J, Petratos S, Richardson S. The Role of Transthyretin in Oligodendrocyte Development. Sci Rep. 2020;10:4189 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 1b1
McCabe M, Cullen E, Barrows C, Shore A, Tooke K, Laprade K, et al. Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 图 1e, 3c, 3d, 4b
Lee M, Jung K, Song J, Sung M, Ahn S, Lee B, et al. IRS2 Amplification as a Predictive Biomarker in Response to Ceritinib in Small Cell Lung Cancer. Mol Ther Oncolytics. 2020;16:188-196 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Duplaquet L, Leroy C, Vinchent A, Paget S, Lefebvre J, Vanden Abeele F, et al. Control of cell death/survival balance by the MET dependence receptor. elife. 2020;9: pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 s5
Trimova G, Yamagata K, Iwata S, Hirata S, Zhang T, Uemura F, et al. Tumour necrosis factor alpha promotes secretion of 14-3-3η by inducing necroptosis in macrophages. Arthritis Res Ther. 2020;22:24 pubmed 出版商
  • 免疫印迹; 人类; 图 4a, 4e
Song K, Oh S, Kim S, Cho H, Lee H, Song J, et al. HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors. Nat Commun. 2020;11:562 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Lin C, Lin W, Cho R, Yang C, Yeh Y, Hsiao L, et al. Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation. J Clin Med. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4a
Ye X, Zhu M, Che X, Wang H, Liang X, Wu C, et al. Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation. J Neuroinflammation. 2020;17:18 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6a
Mlyczynska E, Kurowska P, Drwal E, Opydo Chanek M, Tworzydło W, Kotula Balak M, et al. Apelin and apelin receptor in human placenta: Expression, signalling pathway and regulation of trophoblast JEG‑3 and BeWo cells proliferation and cell cycle. Int J Mol Med. 2020;45:691-702 pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Zhang C, Lin X, Zhao Q, Wang Y, Jiang F, Ji C, et al. YARS as an oncogenic protein that promotes gastric cancer progression through activating PI3K-Akt signaling. J Cancer Res Clin Oncol. 2020;146:329-342 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4c
Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, et al. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. J Exp Med. 2020;217: pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 6e
Zeng S, Bai J, Jiang H, Zhu J, Fu C, He M, et al. Treatment With Liraglutide Exerts Neuroprotection After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the PI3K/AKT/GSK3β Pathway. Front Cell Neurosci. 2019;13:585 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3c
Harde E, Nicholson L, Furones Cuadrado B, Bissen D, Wigge S, Urban S, et al. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 图 5c
Si J, Ma Y, Bi J, Xiong Y, Lv C, Li S, et al. Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties. J Exp Clin Cancer Res. 2019;38:481 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s13h
Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3s2b
Berndsen K, Lis P, Yeshaw W, Wawro P, Nirujogi R, Wightman M, et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Deng Q, Li P, Che M, Liu J, Biswas S, Ma G, et al. Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3d
Nagpal A, Redvers R, Ling X, Ayton S, Fuentes M, Tavancheh E, et al. Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis. Breast Cancer Res. 2019;21:94 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 3a
El Kott A, Shati A, Al Kahtani M, Alqahtani S. Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway. Anal Cell Pathol (Amst). 2019;2019:9627810 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4s2a
Sharma A, Oonthonpan L, Sheldon R, Rauckhorst A, Zhu Z, Tompkins S, et al. Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 图 3b
Uddin G, Zhang L, Shah S, Fukushima A, Wagg C, Gopal K, et al. Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Cardiovasc Diabetol. 2019;18:86 pubmed 出版商
  • 免疫印迹; 人类; 图 10a
Kaur S, Nag A, Gangenahalli G, Sharma K. Peroxisome Proliferator Activated Receptor Gamma Sensitizes Non-small Cell Lung Carcinoma to Gamma Irradiation Induced Apoptosis. Front Genet. 2019;10:554 pubmed 出版商
  • 免疫印迹; 牛; 图 2c
Guo Z, Zhao K, Feng X, Yan D, Yao R, Chen Y, et al. mTORC2 Regulates Lipogenic Gene Expression through PPARγ to Control Lipid Synthesis in Bovine Mammary Epithelial Cells. Biomed Res Int. 2019;2019:5196028 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2f
Pietila M, Sahgal P, Peuhu E, Jäntti N, Paatero I, Närvä E, et al. SORLA regulates endosomal trafficking and oncogenic fitness of HER2. Nat Commun. 2019;10:2340 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2e
  • 免疫印迹; 人类; 图 s2i
Lee Y, Chen M, Lee J, Zhang J, Lin S, Fu T, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019;364: pubmed 出版商
  • 免疫印迹; 人类; 图 7b
Hancock M, Meyer R, Mistry M, Khetani R, Wagschal A, Shin T, et al. Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression. Cell. 2019;177:722-736.e22 pubmed 出版商
  • 免疫印迹; 人类; 图 2b
Liu Y, Wang X, Deng L, Ping L, Shi Y, Zheng W, et al. ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma. Cancer Cell Int. 2019;19:32 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6i
Teissier T, Quersin V, Gnemmi V, Daroux M, Howsam M, Delguste F, et al. Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions. Aging Cell. 2019;18:e12850 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Majumdar T, Sharma S, Kumar M, Hussain M, Chauhan N, Kalia I, et al. Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection. Cell Death Dis. 2019;10:161 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Nava M, Dutta P, Zemke N, Farias Eisner R, Vadgama J, Wu Y. Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. BMC Med Genomics. 2019;12:32 pubmed 出版商
  • 免疫印迹; 猕猴; 图 1d
Hayashi H, Mamun A, Takeyama M, Yamamura A, Zako M, Yagasaki R, et al. Activator of G-protein signaling 8 is involved in VEGF-induced choroidal neovascularization. Sci Rep. 2019;9:1560 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5b
Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, et al. Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency. Nat Commun. 2019;10:632 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 e7a
Ranek M, Kokkonen Simon K, Chen A, Dunkerly Eyring B, Vera M, Oeing C, et al. PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress. Nature. 2019;566:264-269 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7c
  • 免疫印迹; 人类; 图 2b
Wang W, Shen T, Dong B, Creighton C, Meng Y, Zhou W, et al. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. J Clin Invest. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 3e
Rossi F, Legnini I, Megiorni F, Colantoni A, Santini T, Morlando M, et al. Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma. Oncogene. 2019;38:3843-3854 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
  • 免疫印迹; 小鼠; 图 2d
Zhao H, Martin E, Matalkah F, Shah N, Ivanov A, Ruppert J, et al. Conditional knockout of SHP2 in ErbB2 transgenic mice or inhibition in HER2-amplified breast cancer cell lines blocks oncogene expression and tumorigenesis. Oncogene. 2019;38:2275-2290 pubmed 出版商
  • 免疫印迹; 大鼠; 图 8a
  • 免疫印迹; 小鼠; 图 4a
Chen C, Zou L, Lin Q, Yan X, Bi H, Xie X, et al. Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload. Redox Biol. 2019;20:390-401 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s6f
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed 出版商
  • 免疫印迹; 大鼠; 图 1d
  • 免疫印迹; 小鼠; 图 3e, 4e
Hakuno D, Kimura M, Ito S, Satoh J, Nakashima Y, Horie T, et al. Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction. Sci Rep. 2018;8:16749 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:800; 图 s6a
Mu L, Tu Z, Miao L, Ruan H, Kang N, Hei Y, et al. A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing. Nat Commun. 2018;9:4259 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 s1b
  • 免疫印迹; 人类; 图 s1c
Park J, Lee J, Sheu K, Wang L, Balanis N, Nguyen K, et al. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Science. 2018;362:91-95 pubmed 出版商
  • 免疫印迹; 人类; 图 7c
Song K, Kim J, Lee Y, Bae H, Lee H, Woo S, et al. Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance. J Clin Invest. 2018;128:4098-4114 pubmed 出版商
  • 免疫印迹; 人类; 图 6c
Lu D, Song J, Sun Y, Qi F, Liu L, Jin Y, et al. Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders. J Autoimmun. 2018;94:156-165 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4a
Muller T, Braud S, Jüttner R, Voigt B, Paulick K, Sheean M, et al. Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons. EMBO J. 2018;37: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5a
Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed 出版商
  • 免疫印迹; 小鼠; 图 8c
Xie H, Wang Y, Zhang H, Fan Q, Dai D, Zhuang L, et al. Tubular epithelial C1orf54 mediates protection and recovery from acute kidney injury. J Cell Mol Med. 2018;22:4985-4996 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Beyer S, Schwalm S, Pfeilschifter J, Huwiler A. Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis. Cell Physiol Biochem. 2018;47:2522-2533 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s4c
Matesanz N, Nikolic I, Leiva M, Pulgarín Alfaro M, Santamans A, Bernardo E, et al. p38α blocks brown adipose tissue thermogenesis through p38δ inhibition. PLoS Biol. 2018;16:e2004455 pubmed 出版商
  • 免疫印迹; 人类; 图 4f
  • 免疫印迹; 小鼠; 图 2a, s8h, s14e, s15f
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100-1:200; 图 s4d
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3c
Salomè M, Magee A, Yalla K, Chaudhury S, Sarrou E, Carmody R, et al. A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. Cell Death Dis. 2018;9:443 pubmed 出版商
  • 其他; 人类; 图 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s7a
Patra D, DeLassus E, Mueller J, Abou Ezzi G, Sandell L. Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice. Biol Open. 2018;7: pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Nan H, Han L, Ma J, Yang C, Su R, He J. STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1684-1692 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3a
Saunders B, Rudnicka C, Filipovska A, Davies S, Ward N, Hricova J, et al. Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production. Immunol Cell Biol. 2018;96:41-53 pubmed 出版商
  • 免疫印迹; 人类; 图 2b
Barrow A, Edeling M, Trifonov V, Luo J, Goyal P, Bohl B, et al. Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor. Cell. 2018;172:534-548.e19 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6c
Ka M, Kim W. ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway. Neurobiol Dis. 2018;111:138-152 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Yu R, Longo J, van Leeuwen J, Mullen P, Ba Alawi W, Haibe Kains B, et al. Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins. Cancer Res. 2018;78:1347-1357 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4b
Ameen G, Mora S. Cbl downregulation increases RBP4 expression in adipocytes of female mice. J Endocrinol. 2018;236:29-41 pubmed 出版商
  • 免疫印迹; 人类; 图 s4a
Redka D, Gutschow M, Grinstein S, Canton J. Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis. Mol Biol Cell. 2018;29:53-65 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000; 图 5m
Frey J, Kim S, Li Z, Wolfgang M, Riddle R. β-Catenin Directs Long-Chain Fatty Acid Catabolism in the Osteoblasts of Male Mice. Endocrinology. 2018;159:272-284 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 7c
Xie Z, Enkhjargal B, Wu L, Zhou K, Sun C, Hu X, et al. Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats. Neuropharmacology. 2018;128:142-151 pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Zhang F, Virshup D, Cheong J. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. 2018;37:363-376 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2a
Urbschat A, Baer P, Zacharowski K, Sprunck V, Scheller B, Raimann F, et al. Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney. Basic Clin Pharmacol Toxicol. 2018;122:223-232 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Coelho M, de Carné Trécesson S, Rana S, Zecchin D, Moore C, Molina Arcas M, et al. Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA. Immunity. 2017;47:1083-1099.e6 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a
Kishore M, Cheung K, Fu H, Bonacina F, Wang G, Coe D, et al. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017;47:875-889.e10 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Kang H, Kumar D, Liao G, Lichti Kaiser K, Gerrish K, Liao X, et al. GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation. J Clin Invest. 2017;127:4326-4337 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Thaler S, Schmidt M, Roβwag S, Thiede G, Schad A, Sleeman J. Proteasome inhibitors prevent bi-directional HER2/estrogen-receptor cross-talk leading to cell death in endocrine and lapatinib-resistant HER2+/ER+ breast cancer cells. Oncotarget. 2017;8:72281-72301 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2a
Bagarolli R, Tobar N, Oliveira A, Araújo T, Carvalho B, Rocha G, et al. Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice. J Nutr Biochem. 2017;50:16-25 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4a
Tarjus A, Maase M, Jeggle P, Martínez Martínez E, Fassot C, Loufrani L, et al. The endothelial ?ENaC contributes to vascular endothelial function in vivo. PLoS ONE. 2017;12:e0185319 pubmed 出版商
  • 免疫印迹; 人类; 图 13e
Kim J, Park D, Bae H, Park D, Kim D, Lee C, et al. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. 2017;127:3877-3896 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3c
Simond A, Rao T, Zuo D, Zhao J, Muller W. ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor. Oncogene. 2017;36:6059-6066 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 3
Mamo T, Wittern A, Kleppa M, Bohnenpoll T, Weiss A, Kispert A. BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter. Hum Mol Genet. 2017;26:3553-3563 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6d
Pereira R, Tadinada S, Zasadny F, Oliveira K, Pires K, Olvera A, et al. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J. 2017;36:2126-2145 pubmed 出版商
  • 免疫印迹; 犬; 图 s3a
Zhang K, Myllymäki S, Gao P, Devarajan R, Kytölä V, Nykter M, et al. Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT. Oncogene. 2017;36:5681-5694 pubmed 出版商
  • 免疫印迹; 人类; 图 1e
Ventura E, Weller M, Burghardt I. Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells. J Immunol. 2017;198:4569-4574 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Hu L, Liang S, Chen H, Lv T, Wu J, Chen D, et al. ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis. Proc Natl Acad Sci U S A. 2017;114:E3964-E3973 pubmed 出版商
  • 免疫印迹; 小鼠; 1:50; 图 5b
Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann B, et al. Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. J Cell Biol. 2017;216:1567-1577 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5c
Zhou X, Packialakshmi B, Xiao Y, Nurmukhambetova S, Lees J. Progression of experimental autoimmune encephalomyelitis is associated with up-regulation of major sodium transporters in the mouse kidney cortex under a normal salt diet. Cell Immunol. 2017;317:18-25 pubmed 出版商
  • 免疫印迹; pigs ; 图 5b
Cai C, Qian L, Jiang S, Sun Y, Wang Q, Ma D, et al. Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs. Oncotarget. 2017;8:34911-34922 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6a
Kim D, Ko H, Park G, Hur D, Kim Y, Yang J. Vandetanib and ADAM inhibitors synergistically attenuate the pathological migration of EBV-infected retinal pigment epithelial cells by regulating the VEGF-mediated MAPK pathway. Exp Ther Med. 2017;13:1415-1425 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Xiao Z, Gaertner S, Morresi Hauf A, Genzel R, Duell T, Ullrich A, et al. Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients. Neoplasia. 2017;19:385-395 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 3a
Yan X, Zhu Z, Xu S, Yang L, Liao X, Zheng M, et al. MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways. Sci Rep. 2017;7:45915 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 7a
Cai W, Sakaguchi M, Kleinridders A, Gonzalez Del Pino G, Dreyfuss J, O Neill B, et al. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 2017;8:14892 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 13b
Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017;127:1254-1270 pubmed 出版商
  • 免疫印迹; 小鼠; 图 EV4a
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2a
Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, et al. Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro. Int J Oncol. 2017;50:1431-1438 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
  • 免疫印迹; 小鼠; 图 3a
Obeid S, Wankell M, Charrez B, Sternberg J, Kreuter R, Esmaili S, et al. Adiponectin confers protection from acute colitis and restricts a B cell immune response. J Biol Chem. 2017;292:6569-6582 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Møller A, Kampmann U, Hedegaard J, Thorsen K, Nordentoft I, Vendelbo M, et al. Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes. Sci Rep. 2017;7:43775 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Pan X, Wang Y, Lübke T, Hinek A, Pshezhetsky A. Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings. PLoS ONE. 2017;12:e0172854 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2b
Sethna F, Feng W, Ding Q, ROBISON A, Feng Y, Wang H. Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model. Nat Commun. 2017;8:14359 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 1h
Xu W, Li B, Guan X, Chung S, Wang Y, Yip Y, et al. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun. 2017;8:14399 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3a
Yang G, Zhao Z, Qin T, Wang D, Chen L, Xiang R, et al. TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation. FASEB J. 2017;31:2001-2012 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 7a
Zhu Y, Takayama T, Wang B, Kent A, Zhang M, Binder B, et al. Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol. Sci Rep. 2017;7:41916 pubmed 出版商
  • 免疫印迹; 人类; 图 s7a
Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, et al. Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Sci Rep. 2017;7:41434 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 1b
Cederquist C, Lentucci C, Martinez Calejman C, Hayashi V, Orofino J, GUERTIN D, et al. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017;6:125-137 pubmed 出版商
  • 免疫组化; pigs ; 1:100; 图 6a
Guo J, Kim N, Cui X. Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs. PLoS ONE. 2017;12:e0170624 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4c
Barcus C, O Leary K, Brockman J, Rugowski D, Liu Y, Garcia N, et al. Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells. Breast Cancer Res. 2017;19:9 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1e
Gross S, Rotwein P. Quantification of growth factor signaling and pathway cross talk by live-cell imaging. Am J Physiol Cell Physiol. 2017;312:C328-C340 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 5d
Dror E, Dalmas E, Meier D, Wueest S, Thévenet J, Thienel C, et al. Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol. 2017;18:283-292 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, et al. Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. J Neuroinflammation. 2017;14:9 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1b
Rahman A, Haugh J. Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation. J Biol Chem. 2017;292:2866-2872 pubmed 出版商
  • 免疫印迹; 人类; 图 4d
Zhao B, Hu W, Kumar S, Gonyo P, Rana U, Liu Z, et al. The Nogo-B receptor promotes Ras plasma membrane localization and activation. Oncogene. 2017;36:3406-3416 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5h
Oller J, Méndez Barbero N, Ruiz E, Villahoz S, Renard M, Canelas L, et al. Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. Nat Med. 2017;23:200-212 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3a
Reynolds L, Dickens B, Green B, Marsit C, Pearson K. Using neonatal skin to study the developmental programming of aging. Exp Gerontol. 2017;94:93-98 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 3
Sivagurunathan S, Palanisamy K, Arunachalam J, Chidambaram S. Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway. Mol Cell Biochem. 2017;427:145-156 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500; 图 1b
Grossi M, Bhattachariya A, Nordström I, Turczynska K, Svensson D, Albinsson S, et al. Pyk2 inhibition promotes contractile differentiation in arterial smooth muscle. J Cell Physiol. 2017;232:3088-3102 pubmed 出版商
  • 免疫印迹; 人类
Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 1f
Naeem A, Tommasi C, Cole C, Brown S, Zhu Y, Way B, et al. A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic d. J Allergy Clin Immunol. 2017;139:1228-1241 pubmed 出版商
  • 免疫印迹; 人类; 1:3000; 图 6a
Liu W, Huang K, Lu M, Huang H, Chen C, Cheng Y, et al. TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability. Oncogene. 2017;36:2715-2723 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5d-f
Langhi C, Arias N, Rajamoorthi A, Basta J, Lee R, Baldán A. Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance. J Lipid Res. 2017;58:81-91 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Spencer Smith R, Koide A, Zhou Y, Eguchi R, Sha F, Gajwani P, et al. Inhibition of RAS function through targeting an allosteric regulatory site. Nat Chem Biol. 2017;13:62-68 pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Patel S, Trivedi G, Darie C, Clarkson B. The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer. J Cell Mol Med. 2017;21:456-466 pubmed 出版商
  • 免疫印迹; 小鼠; 图 9f
Szewczyk L, Brozko N, Nagalski A, Röckle I, Werneburg S, Hildebrandt H, et al. ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons. Glia. 2017;65:34-49 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5d
Chen R, Duan J, Li L, Ma Q, Sun Q, Ma J, et al. mTOR promotes pituitary tumor development through activation of PTTG1. Oncogene. 2017;36:979-988 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6e
Hammers D, Sleeper M, Forbes S, Coker C, Jirousek M, Zimmer M, et al. Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle. JCI Insight. 2016;1:e90341 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, et al. Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway. Sci Rep. 2016;6:39557 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Li Y, Buijs Gladdines J, Canté Barrett K, Stubbs A, Vroegindeweij E, Smits W, et al. IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. PLoS Med. 2016;13:e1002200 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 6a
Wymant J, Hiscox S, Westwell A, Urbé S, Clague M, Jones A. The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer. J Cancer. 2016;7:2388-2407 pubmed
  • 免疫印迹; 小鼠; 图 4
Ramratnam M, Salama G, Sharma R, Wang D, Smith S, Banerjee S, et al. Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. PLoS ONE. 2016;11:e0167681 pubmed 出版商
  • 免疫细胞化学; 人类; 图 6b
  • 免疫印迹; 人类; 图 6a
Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, et al. CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells. J Exp Clin Cancer Res. 2016;35:190 pubmed
  • 免疫印迹; 小鼠; 图 2
Mueller A, van Velthoven C, Fukumoto K, Cheung T, Rando T. Intronic polyadenylation of PDGFR? in resident stem cells attenuates muscle fibrosis. Nature. 2016;540:276-279 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Torgersen M, Klokk T, Kavaliauskiene S, Klose C, Simons K, Skotland T, et al. The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget. 2016;7:86871-86888 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4i
Wang X, Cao Q, Yu L, Shi H, Xue B, Shi H. Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity. JCI Insight. 2016;1:e87748 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Vidimar V, Gius D, Chakravarti D, Bulun S, Wei J, Kim J. Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas. Sci Adv. 2016;2:e1601132 pubmed
  • 免疫印迹; 人类; 1:1000; 图 4a
Pandey R, Mehrotra S, Sharma S, Gudde R, Sundar S, Shaha C. Leishmania donovani-Induced Increase in Macrophage Bcl-2 Favors Parasite Survival. Front Immunol. 2016;7:456 pubmed
  • 免疫印迹; 人类; 图 3b
Alekhina O, Marchese A. ?-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. J Biol Chem. 2016;291:26083-26097 pubmed
  • 免疫印迹; 人类; 1:1000; 图 3a
Li R, Xu J, Fu C, Zhang J, Zheng Y, Jia H, et al. Regulation of mTORC1 by lysosomal calcium and calmodulin. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s4b
Zhang Q, Zhang Y, Parsels J, Lohse I, Lawrence T, Pasca di Magliano M, et al. Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia. 2016;18:666-673 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7
Sanchez T, Zhang G, Li J, Dai L, Mirshahidi S, Wall N, et al. Immunoseroproteomic Profiling in African American Men with Prostate Cancer: Evidence for an Autoantibody Response to Glycolysis and Plasminogen-Associated Proteins. Mol Cell Proteomics. 2016;15:3564-3580 pubmed
  • 免疫组化-石蜡切片; 人类
Southworth T, Plumb J, Gupta V, Pearson J, Ramis I, Lehner M, et al. Anti-inflammatory potential of PI3K? and JAK inhibitors in asthma patients. Respir Res. 2016;17:124 pubmed
  • 免疫印迹; 小鼠; 1:5000; 图 4e
Kubota N, Kubota T, Kajiwara E, Iwamura T, Kumagai H, Watanabe T, et al. Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity. Nat Commun. 2016;7:12977 pubmed 出版商
  • 免疫印迹; 人类; 图 9c
Rodina A, Wang T, Yan P, Gomes E, Dunphy M, Pillarsetty N, et al. The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature. 2016;538:397-401 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Yong K, Li A, Ou W, Hong C, Zhao W, Wang F, et al. Targeting SALL4 by entinostat in lung cancer. Oncotarget. 2016;7:75425-75440 pubmed 出版商
  • 免疫印迹; 人类; 图 7
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠; 图 1
Cizmecioglu O, Ni J, Xie S, Zhao J, Roberts T. Rac1-mediated membrane raft localization of PI3K/p110? is required for its activation by GPCRs or PTEN loss. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 小鼠; 图 3a
Yang Z, Tsuchiya H, Zhang Y, Lee S, Liu C, Huang Y, et al. REV-ERB? Activates C/EBP Homologous Protein to Control Small Heterodimer Partner-Mediated Oscillation of Alcoholic Fatty Liver. Am J Pathol. 2016;186:2909-2920 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3c
Wang A, Cui M, Qu H, Di J, Wang Z, Xing J, et al. Induction of anti-EGFR immune response with mimotopes identified from a phage display peptide library by panitumumab. Oncotarget. 2016;7:75293-75306 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 1
Jansson D, Scotter E, Rustenhoven J, Coppieters N, Smyth L, Oldfield R, et al. Interferon-? blocks signalling through PDGFR? in human brain pericytes. J Neuroinflammation. 2016;13:249 pubmed
  • 免疫印迹; 人类; 1:1000; 图 s7c
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed 出版商
  • 免疫印迹; 人类; 图 6c
Rittig N, Bach E, Thomsen H, Pedersen S, Nielsen T, Jørgensen J, et al. Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial. PLoS ONE. 2016;11:e0162167 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:25; 图 3
Phatak N, Stankowska D, Krishnamoorthy R. Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma. Mol Vis. 2016;22:1048-61 pubmed
  • 免疫印迹; 人类; 图 4b
Caporali S, Alvino E, Lacal P, Levati L, Giurato G, Memoli D, et al. Targeting the PI3K/AKT/mTOR pathway overcomes the stimulating effect of dabrafenib on the invasive behavior of melanoma cells with acquired resistance to the BRAF inhibitor. Int J Oncol. 2016;49:1164-74 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Woodall B, Woodall M, Luongo T, Grisanti L, Tilley D, Elrod J, et al. Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy. J Biol Chem. 2016;291:21913-21924 pubmed
  • 免疫印迹; 人类; 图 6a
Cunningham C, Li S, Vizeacoumar F, Bhanumathy K, Lee J, Parameswaran S, et al. Therapeutic relevance of the protein phosphatase 2A in cancer. Oncotarget. 2016;7:61544-61561 pubmed 出版商
  • 免疫印迹; 小鼠; 1:250; 图 s7e
Vermeij W, Dollé M, Reiling E, Jaarsma D, Payan Gomez C, Bombardieri C, et al. Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature. 2016;537:427-431 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Lee J, Lee W, Seol M, Lee S, Kim D, Kim H, et al. Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation. Oncotarget. 2016;7:66728-66739 pubmed 出版商
  • 免疫印迹; 人类; 1:1500; 图 4b
Efazat G, Novak M, Kaminskyy V, De Petris L, Kanter L, Juntti T, et al. Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer. Oncotarget. 2016;7:60332-60347 pubmed 出版商
  • 免疫印迹; 大鼠; 图 4a
Wang D, Mitchell E. Cognition and Synaptic-Plasticity Related Changes in Aged Rats Supplemented with 8- and 10-Carbon Medium Chain Triglycerides. PLoS ONE. 2016;11:e0160159 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3a
Yang J, Song T, Jo C, Park J, Lee H, Song I, et al. Differential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch. Exp Mol Med. 2016;48:e252 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3c
Nadeau Vallée M, Boudreault A, Leimert K, Hou X, Obari D, Madaan A, et al. Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth. Biol Reprod. 2016;95:72 pubmed
  • 免疫印迹; 大鼠; 图 1
Ogasawara R, Fujita S, Hornberger T, Kitaoka Y, Makanae Y, Nakazato K, et al. The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Sci Rep. 2016;6:31142 pubmed 出版商
  • 免疫印迹; 大鼠; 图 2
Kawamoto E, Koshinaka K, Yoshimura T, Masuda H, Kawanaka K. Immobilization rapidly induces muscle insulin resistance together with the activation of MAPKs (JNK and p38) and impairment of AS160 phosphorylation. Physiol Rep. 2016;4: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6b
Fiedor E, Gregoraszczuk E. The molecular mechanism of action of superactive human leptin antagonist (SHLA) and quadruple leptin mutein Lan-2 on human ovarian epithelial cell lines. Cancer Chemother Pharmacol. 2016;78:611-22 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Bao H, Liu P, Jiang K, Zhang X, Xie L, Wang Z, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncol Lett. 2016;12:1058-1066 pubmed
  • 免疫印迹; 人类; 1:1000; 图 4c
Metz H, Kargl J, Busch S, Kim K, Kurland B, Abberbock S, et al. Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma. Proc Natl Acad Sci U S A. 2016;113:8795-800 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1d
Diez H, Benitez M, Fernandez S, Torres Aleman I, Garrido J, Wandosell F. Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation. Biochim Biophys Acta. 2016;1863:2574-2583 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5c
Ge X, Huang S, Gao H, Han Z, Chen F, Zhang S, et al. miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis. Brain Res. 2016;1650:31-40 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
Song M, Wang Y, Shang Z, Liu X, Xie D, Wang Q, et al. Bystander autophagy mediated by radiation-induced exosomal miR-7-5p in non-targeted human bronchial epithelial cells. Sci Rep. 2016;6:30165 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5
Jang H, Lee G, Selby C, Lee G, Jeon Y, Lee J, et al. SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nat Commun. 2016;7:12180 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s2
Deblois G, Smith H, Tam I, Gravel S, Caron M, Savage P, et al. ERR? mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nat Commun. 2016;7:12156 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7d
Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, et al. IRF3 promotes adipose inflammation and insulin resistance and represses browning. J Clin Invest. 2016;126:2839-54 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2i
Eid S, Boutary S, Braych K, Sabra R, Massaad C, Hamdy A, et al. mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes. Antioxid Redox Signal. 2016;25:703-719 pubmed
  • 免疫印迹; 大鼠; 图 1c
Zhou Y, Wu Y, Qin Y, Liu L, Wan J, Zou L, et al. Ampelopsin Improves Insulin Resistance by Activating PPAR? and Subsequently Up-Regulating FGF21-AMPK Signaling Pathway. PLoS ONE. 2016;11:e0159191 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Huang C, Lee C, Lin H, Chang J. Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors. Sci Rep. 2016;6:29256 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Chakedis J, French R, Babicky M, Jaquish D, Mose E, Cheng P, et al. Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics. Oncotarget. 2016;7:45959-45975 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Liu C, Lin S, Hsu H, Yang S, Lin C, Yang M, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016;7:11798 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5d
Tisza M, Zhao W, Fuentes J, Prijic S, Chen X, Levental I, et al. Motility and stem cell properties induced by the epithelial-mesenchymal transition require destabilization of lipid rafts. Oncotarget. 2016;7:51553-51568 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Cui Y, Zhao J, Yi L, Jiang Y. microRNA-153 Targets mTORC2 Component Rictor to Inhibit Glioma Cells. PLoS ONE. 2016;11:e0156915 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4c
Li W, Jin D, Hata M, Takai S, Yamanishi K, Shen W, et al. Dysfunction of mitochondria and deformed gap junctions in the heart of IL-18-deficient mice. Am J Physiol Heart Circ Physiol. 2016;311:H313-25 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Priego N, Arechederra M, Sequera C, Bragado P, Vázquez Carballo A, Gutierrez Uzquiza A, et al. C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38? activation, while it impairs tumor growth through p38?-independent mechanisms. Oncotarget. 2016;7:45060-45078 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Jeong A, Han S, Lee S, Su Park J, Lu Y, Yu S, et al. Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway. Sci Rep. 2016;6:27391 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Leonard S, Kinsella G, Benetti E, Findlay J. Regulating the effects of GPR21, a novel target for type 2 diabetes. Sci Rep. 2016;6:27002 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
van Ree J, Nam H, Jeganathan K, Kanakkanthara A, van Deursen J. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nat Cell Biol. 2016;18:814-21 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Park J, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, et al. Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids. PLoS ONE. 2016;11:e0156334 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Kwon H, Choi G, Ryu S, Kwon S, Kim S, Booth C, et al. Stepwise phosphorylation of p65 promotes NF-?B activation and NK cell responses during target cell recognition. Nat Commun. 2016;7:11686 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 2f
Vazirani R, Verma A, Sadacca L, Buckman M, Picatoste B, Beg M, et al. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016;65:1577-89 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2f
Zhang W, Wu M, Kim T, Jariwala R, Garvey W, Luo N, et al. Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet-Induced Insulin Resistance. Diabetes. 2016;65:2380-91 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 6
Kohler T, Scholz A, Kiachludis D, Hammerschmidt S. Induction of Central Host Signaling Kinases during Pneumococcal Infection of Human THP-1 Cells. Front Cell Infect Microbiol. 2016;6:48 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 st2
Gharib M, Tao H, Fungwe T, Hajri T. Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart. PLoS ONE. 2016;11:e0155611 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s2
Wang J, Hu K, Guo J, Cheng F, Lv J, Jiang W, et al. Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK. Nat Commun. 2016;7:11363 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Hsieh M, Yang P, Wong L, Lee J. The AXL receptor tyrosine kinase is associated with adverse prognosis and distant metastasis in esophageal squamous cell carcinoma. Oncotarget. 2016;7:36956-36970 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s1h
Itoh Y, Higuchi M, Oishi K, Kishi Y, Okazaki T, Sakai H, et al. PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex. Proc Natl Acad Sci U S A. 2016;113:E2955-64 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Ting W, Yang J, Kuo C, Xiao Z, Lu X, Yeh Y, et al. Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts. Oncotarget. 2016;7:39017-39025 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Huang Y, Lin C, Liao H, Liu C, Chen Y, Chiu W, et al. Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. Neuroscience. 2016;328:201-9 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Choi H, Kim M, Choi Y, Shin Y, Cho S, Ko S. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med. 2016;16:122 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Boothe T, Lim G, Cen H, Skovsø S, Piske M, Li S, et al. Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells. Mol Metab. 2016;5:366-378 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Thomas A, Belaidi E, Aron Wisnewsky J, van der Zon G, Levy P, Clement K, et al. Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice. Sci Rep. 2016;6:24618 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5
Dokas J, Chadt A, Joost H, Al Hasani H. Tbc1d1 deletion suppresses obesity in leptin-deficient mice. Int J Obes (Lond). 2016;40:1242-9 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Zeng W, Liu Q, Chen Z, Wu X, Zhong Y, Wu J. Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-?B Pathway. J Cancer. 2016;7:746-57 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5
Jeong J, Noh M, Choi J, Lee H, Kim S. Neuroprotective and antioxidant activities of bamboo salt soy sauce against H2O2-induced oxidative stress in rat cortical neurons. Exp Ther Med. 2016;11:1201-1210 pubmed
  • 免疫印迹; 小鼠; 图 4
Yang E, Ahn S, Lee K, Mahmood U, Kim H. Early Behavioral Abnormalities and Perinatal Alterations of PTEN/AKT Pathway in Valproic Acid Autism Model Mice. PLoS ONE. 2016;11:e0153298 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5c
Katlinskaya Y, Katlinski K, Yu Q, Ortiz A, Beiting D, Brice A, et al. Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. Cell Rep. 2016;15:171-180 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4f
Schlam D, Canton J, Carreño M, Kopinski H, Freeman S, Grinstein S, et al. Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis. MBio. 2016;7:e02242 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 `1
Rhee M, Lee S, Kim J, Ham D, Park H, Yang H, et al. Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells. Sci Rep. 2016;6:23960 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Patzke C, Acuna C, Giam L, Wernig M, Südhof T. Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation. J Exp Med. 2016;213:499-515 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Lee I, Maniar K, Lydon J, Kim J. Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells. Oncogene. 2016;35:5191-201 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Lynch J, McEwen R, Crafter C, McDermott U, Garnett M, Barry S, et al. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. Oncotarget. 2016;7:22128-39 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Morena D, Maestro N, Bersani F, Forni P, Lingua M, Foglizzo V, et al. Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 5a
Lisewski U, Koehncke C, Wilck N, Buschmeyer B, Pieske B, Roepke T. Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice. FASEB J. 2016;30:2476-89 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Kurimoto R, Iwasawa S, Ebata T, Ishiwata T, Sekine I, Tada Y, et al. Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation. Int J Oncol. 2016;48:1825-36 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Afsar T, Trembley J, Salomon C, Razak S, Khan M, Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Sci Rep. 2016;6:23077 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 s1
Koussounadis A, Langdon S, Um I, Kay C, Francis K, Harrison D, et al. Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models. BMC Cancer. 2016;16:205 pubmed 出版商
  • 免疫印迹; 斑马鱼; 1:1000; 图 2
Hirth S, Bühler A, Bührdel J, Rudeck S, Dahme T, Rottbauer W, et al. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS ONE. 2016;11:e0150323 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Jang C, Oh S, Wada S, Rowe G, Liu L, Chan M, et al. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016;22:421-6 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1d
Yang P, Leu D, Ye K, Srinivasan C, Fike J, Huang T. Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist. Exp Neurol. 2016;279:178-186 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 6
Thakur A, Nigri J, Lac S, Leca J, Bressy C, Berthezene P, et al. TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma. Cell Death Differ. 2016;23:1358-70 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Ardini E, Menichincheri M, Banfi P, Bosotti R, De Ponti C, Pulci R, et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016;15:628-39 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Singh A, Joshi S, Zulcic M, Alcaraz M, GARLICH J, Morales G, et al. PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma. PLoS ONE. 2016;11:e0150836 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Li Y, Wei Z, Dong B, Lian Z, Xu Y. Silencing of phosphoglucose isomerase/autocrine motility factor decreases U87 human glioblastoma cell migration. Int J Mol Med. 2016;37:998-1004 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Jing H, Sun W, Fan J, Zhang Y, Yang J, Jia J, et al. Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways. Mol Med Rep. 2016;13:3009-16 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 s2
Santio N, Salmela M, Arola H, Eerola S, Heino J, Rainio E, et al. The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways. Exp Cell Res. 2016;342:113-24 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Lyabin D, Ovchinnikov L. Selective regulation of YB-1 mRNA translation by the mTOR signaling pathway is not mediated by 4E-binding protein. Sci Rep. 2016;6:22502 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 4
Wong H, Jin G, Cao R, Zhang S, Cao Y, Zhou Z. MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nat Commun. 2016;7:10824 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, et al. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016;64:425-38 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 表 1
Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Chang T, Chen C, Wu Y, Liu J, Kuo Y, Lee K, et al. Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma. PLoS ONE. 2016;11:e0149897 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
Seip K, Fleten K, Barkovskaya A, Nygaard V, Haugen M, Engesæter B, et al. Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors. Oncotarget. 2016;7:19997-20015 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Viana Huete V, Guillen C, García Aguilar A, García G, Fernandez S, Kahn C, et al. Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity. Endocrinology. 2016;157:1495-511 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 4c
Bai D, Zhang Y, Shen M, Sun Y, Xia Q, Zhang Y, et al. Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. Sci Rep. 2016;6:22068 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50; 图 2
  • 免疫印迹; 人类; 图 s11
Sancho Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, et al. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016;7:10743 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Liao B, McManus S, Hughes W, Schmitz Peiffer C. Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes. Mol Endocrinol. 2016;30:417-28 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Cui J, Xia T, Xie D, Gao Y, Jia Z, Wei D, et al. HGF/Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes. Oncogene. 2016;35:4708-18 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s10b
Demetriades C, Plescher M, Teleman A. Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun. 2016;7:10662 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Chang C, Hale S, Cox C, Blair A, Kronsteiner B, Grabowska R, et al. Junctional Adhesion Molecule-A Is Highly Expressed on Human Hematopoietic Repopulating Cells and Associates with the Key Hematopoietic Chemokine Receptor CXCR4. Stem Cells. 2016;34:1664-78 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2e
Liu Y, Takahashi Y, Desai N, Zhang J, Serfass J, Shi Y, et al. Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance. Sci Rep. 2016;6:20453 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3b
Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Ying W, Tseng A, Chang R, Wang H, Lin Y, Kanameni S, et al. miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Sci Rep. 2016;6:20176 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Grego Bessa J, Bloomekatz J, Castel P, Omelchenko T, Baselga J, Anderson K. The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. elife. 2016;5:e12034 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Goulielmaki M, Koustas E, Moysidou E, Vlassi M, Sasazuki T, Shirasawa S, et al. BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. Oncotarget. 2016;7:9188-221 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam K, et al. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. PLoS ONE. 2016;11:e0147344 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1a
Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Cipriani G, Gibbons S, Verhulst P, Choi K, Eisenman S, Hein S, et al. Diabetic Csf1op/op mice lacking macrophages are protected against the development of delayed gastric emptying. Cell Mol Gastroenterol Hepatol. 2016;2:40-47 pubmed
  • 免疫印迹; 人类; 图 7
Pivonello C, Negri M, De Martino M, Napolitano M, De Angelis C, Provvisiero D, et al. The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma. Oncotarget. 2016;7:9718-31 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1s3j
Carroll B, Maetzel D, Maddocks O, Otten G, Ratcliff M, Smith G, et al. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4b
Ho N, Morrison J, Silva A, Coomber B. The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression. Biosci Rep. 2016;36:e00299 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Lv H, Zhang Z, Wu X, Wang Y, Li C, Gong W, et al. Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. PLoS ONE. 2016;11:e0145195 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 1b
Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016;7:10060 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3c
Ishibashi T, Yaguchi A, Terada K, Ueno Yokohata H, Tomita O, Iijima K, et al. Ph-like ALL-related novel fusion kinase ATF7IP-PDGFRB exhibits high sensitivity to tyrosine kinase inhibitors in murine cells. Exp Hematol. 2016;44:177-88.e5 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50; 图 6d
Audette D, Anand D, So T, Rubenstein T, Lachke S, Lovicu F, et al. Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression. Development. 2016;143:318-28 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Debruyne D, Bhatnagar N, Sharma B, Luther W, Moore N, Cheung N, et al. ALK inhibitor resistance in ALK(F1174L)-driven neuroblastoma is associated with AXL activation and induction of EMT. Oncogene. 2016;35:3681-91 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Chen J, Chen Y, Yen C, Chen W, Huang W. HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3. Oncotarget. 2016;7:473-89 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
McIlroy G, Tammireddy S, Maskrey B, Grant L, Doherty M, Watson D, et al. Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue. Biochem Pharmacol. 2016;100:86-97 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Diersch S, Wirth M, Schneeweis C, Jörs S, Geisler F, Siveke J, et al. Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells. Oncogene. 2016;35:3880-6 pubmed 出版商
  • 免疫印迹; 人类; 图 S3
Wang Z, Ma B, Li H, Xiao X, Zhou W, Liu F, et al. Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC. Oncotarget. 2016;7:509-23 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Alsafadi S, Tourpin S, Bessoltane N, Salomé Desnoulez S, Vassal G, André F, et al. Nuclear localization of the caspase-3-cleaved form of p73 in anoikis. Oncotarget. 2016;7:12331-43 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 6
Hu Y, Zhang Y, Tian K, Xun C, Wang S, Lv D. Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro. Mol Med Rep. 2016;13:49-58 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
Verbrugge S, Al M, Assaraf Y, Kammerer S, Chandrupatla D, Honeywell R, et al. Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR. Oncotarget. 2016;7:5240-57 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Pinel A, Rigaudière J, Laillet B, Pouyet C, Malpuech Brugère C, Prip Buus C, et al. N-3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells. Biochim Biophys Acta. 2016;1861:12-20 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Chakedis J, French R, Babicky M, Jaquish D, Howard H, Mose E, et al. A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. Oncogene. 2016;35:3249-59 pubmed 出版商
  • 免疫印迹; 人类; 图 6c
Barbáchano A, Fernández Barral A, Pereira F, Segura M, Ordóñez Morán P, Carrillo de Santa Pau E, et al. SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Oncogene. 2016;35:2991-3003 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Yokdang N, Hatakeyama J, Wald J, Simion C, Tellez J, Chang D, et al. LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene. 2016;35:2932-47 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Kitatani K, Usui T, Sriraman S, Toyoshima M, Ishibashi M, Shigeta S, et al. Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid. Oncogene. 2016;35:2801-12 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6g
Lee Y, Yun M, Kim H, Jeon B, Park B, Lee B, et al. Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK. Int J Obes (Lond). 2016;40:356-65 pubmed 出版商
  • 免疫印迹; 小鼠; 1:300
Zarpelon A, Rodrigues F, Lopes A, Souza G, Carvalho T, Pinto L, et al. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB J. 2016;30:54-65 pubmed 出版商
  • 免疫印迹; 人类
Kurppa K, Denessiouk K, Johnson M, Elenius K. Activating ERBB4 mutations in non-small cell lung cancer. Oncogene. 2016;35:1283-91 pubmed 出版商
  • 免疫印迹; 人类
Kozlova N, Samoylenko A, Drobot L, Kietzmann T. Urokinase is a negative modulator of Egf-dependent proliferation and motility in the two breast cancer cell lines MCF-7 and MDA-MB-231. Mol Carcinog. 2016;55:170-81 pubmed 出版商
Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019;176:1113-1127.e16 pubmed 出版商
Garner E, Williams A, Stafman L, Aye J, Mroczek Musulman E, Moore B, et al. FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts. Sci Rep. 2018;8:6913 pubmed 出版商
Luciano A, Zhou W, Santana J, Kyriakides C, Velazquez H, Sessa W. CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues. J Biol Chem. 2018;293:9126-9136 pubmed 出版商
Beadnell T, Nassar K, Rose M, Clark E, Danysh B, Hofmann M, et al. Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer. Oncogenesis. 2018;7:23 pubmed 出版商
Rossi M, Zhu L, McMillin S, Pydi S, Jain S, Wang L, et al. Hepatic Gi signaling regulates whole-body glucose homeostasis. J Clin Invest. 2018;128:746-759 pubmed 出版商
Kang Y, Hsu W, Wu C, Hsin I, Wu P, Yeh K, et al. Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells. Oncotarget. 2017;8:105536-105552 pubmed 出版商
Jing H, Zhang X, Wisner S, Chen X, Spiegelman N, Linder M, et al. SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. elife. 2017;6: pubmed 出版商
Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, et al. LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. elife. 2017;6: pubmed 出版商
Knittle A, Helkkula M, Johnson M, Sundvall M, Elenius K. SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase. J Biol Chem. 2017;292:19890-19904 pubmed 出版商
Umezawa Y, Akiyama H, Okada K, Ishida S, Nogami A, Oshikawa G, et al. Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1). J Biol Chem. 2017;292:19639-19655 pubmed 出版商
Wang L, Scott I, Zhu L, Wu K, Han K, Chen Y, et al. GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis. Nat Commun. 2017;8:523 pubmed 出版商
Simón Carrasco L, Grana O, Salmón M, Jacob H, Gutierrez A, Jiménez G, et al. Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev. 2017;31:1456-1468 pubmed 出版商
Van Ngo H, Bhalla M, Chen D, Ireton K. A role for host cell exocytosis in InlB-mediated internalisation of Listeria monocytogenes. Cell Microbiol. 2017;19: pubmed 出版商
Li L, Fan L, Zhou J, Grantham J, Calvet J, Sage J, et al. Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. J Clin Invest. 2017;127:2751-2764 pubmed 出版商
Kim D, Mecham R, Trackman P, Roy S. Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis. Invest Ophthalmol Vis Sci. 2017;58:2725-2731 pubmed 出版商
Zhong L, Shu W, Dai W, Gao B, Xiong S. Reactive Oxygen Species-Mediated c-Jun NH2-Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction. J Virol. 2017;91: pubmed 出版商
Bhalla M, Law D, Dowd G, Ireton K. Host Serine/Threonine Kinases mTOR and Protein Kinase C-? Promote InlB-Mediated Entry of Listeria monocytogenes. Infect Immun. 2017;85: pubmed 出版商
Ohnishi Y, Yasui H, Kakudo K, Nozaki M. Regulation of cell migration via the EGFR signaling pathway in oral squamous cell carcinoma cells. Oncol Lett. 2017;13:930-936 pubmed 出版商
Schweighoffer E, Nys J, Vanes L, Smithers N, Tybulewicz V. TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK. J Exp Med. 2017;214:1269-1280 pubmed 出版商
Narayan R, Fedrigo C, Brands E, Dik R, Stalpers L, Baumert B, et al. The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures. BMC Cancer. 2017;17:204 pubmed 出版商
Coomans de Brachène A, Dif N, de Rocca Serra A, Bonnineau C, Velghe A, Larondelle Y, et al. PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase. FEBS Open Bio. 2017;7:414-423 pubmed 出版商
Wang L, Cooper J. Optogenetic control of the Dab1 signaling pathway. Sci Rep. 2017;7:43760 pubmed 出版商
Liao X, Zhang A, Zheng M, Li M, Chen C, Xu H, et al. Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways. Sci Rep. 2017;7:43639 pubmed 出版商
Subramaniam M, Cicek M, Pitel K, Bruinsma E, Nelson Holte M, Withers S, et al. TIEG1 modulates ?-catenin sub-cellular localization and enhances Wnt signaling in bone. Nucleic Acids Res. 2017;45:5170-5182 pubmed 出版商
Goh Q, Millay D. Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy. elife. 2017;6: pubmed 出版商
Parker L, Trewin A, Levinger I, Shaw C, Stepto N. The effect of exercise-intensity on skeletal muscle stress kinase and insulin protein signaling. PLoS ONE. 2017;12:e0171613 pubmed 出版商
Milioto C, Malena A, Maino E, Polanco M, Marchioretti C, Borgia D, et al. Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes. Sci Rep. 2017;7:41046 pubmed 出版商
Moniz L, Surinova S, Ghazaly E, Velasco L, Haider S, Rodríguez Prados J, et al. Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate. Sci Rep. 2017;7:39985 pubmed 出版商
Maolake A, Izumi K, Shigehara K, Natsagdorj A, Iwamoto H, Kadomoto S, et al. Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis. Oncotarget. 2017;8:9739-9751 pubmed 出版商
Kozlova N, Wottawa M, Katschinski D, Kristiansen G, Kietzmann T. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget. 2017;8:9885-9898 pubmed 出版商
Mateo F, Arenas E, Aguilar H, Serra Musach J, de Garibay G, Boni J, et al. Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. Oncogene. 2017;36:2737-2749 pubmed 出版商
Singh R, Dhanyamraju P, Lauth M. DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway. Oncotarget. 2017;8:833-845 pubmed 出版商
Zelenko Z, Gallagher E, Tobin Hess A, Belardi V, Rostoker R, Blank J, et al. Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression. Oncogene. 2017;36:1394-1403 pubmed 出版商
Abdelbaset Ismail A, Borkowska Rzeszotek S, Kubis E, Bujko K, Brzeźniakiewicz Janus K, Bolkun L, et al. Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1. Leukemia. 2017;31:446-458 pubmed 出版商
Kang J, Park S, Guo T, Ha J, Lee D, Kim J, et al. Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid. Oxid Med Cell Longev. 2016;2016:6981595 pubmed 出版商
Sun L, Liu X, Fu H, Zhou W, Zhong D. 2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells. PLoS ONE. 2016;11:e0168793 pubmed 出版商
Vilà L, Roca C, Elias I, Casellas A, Lage R, Franckhauser S, et al. AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance. Mol Ther Methods Clin Dev. 2016;5:16072 pubmed
Xin X, Li Y, Yang X. SIX1 is overexpressed in endometrial carcinoma and promotes the malignant behavior of cancer cells through ERK and AKT signaling. Oncol Lett. 2016;12:3435-3440 pubmed
Roberts C, Tran M, Pitruzzello M, Wen W, Loeza J, Dellinger T, et al. TWIST1 drives cisplatin resistance and cell survival in an ovarian cancer model, via upregulation of GAS6, L1CAM, and Akt signalling. Sci Rep. 2016;6:37652 pubmed 出版商
Labbé S, Mouchiroud M, Caron A, Secco B, Freinkman E, Lamoureux G, et al. mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold. Sci Rep. 2016;6:37223 pubmed 出版商
Kim H. The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation. Sci Rep. 2016;6:37280 pubmed 出版商
Drake A, Kaur M, Iliopoulou B, Phennicie R, Hanson A, Chen J. Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling. PLoS ONE. 2016;11:e0166280 pubmed 出版商
Dang F, Wu R, Wang P, Wu Y, Azam M, Xu Q, et al. Fasting and Feeding Signals Control the Oscillatory Expression of Angptl8 to Modulate Lipid Metabolism. Sci Rep. 2016;6:36926 pubmed 出版商
Phyu S, Tseng C, Fleming I, Smith T. Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3. Sci Rep. 2016;6:36544 pubmed 出版商
Fu X, Li Y, Alvero A, Li J, Wu Q, Xiao Q, et al. MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival. Oncotarget. 2016;7:80633-80654 pubmed 出版商
Conley LaComb M, Semaan L, Singareddy R, Li Y, Heath E, Kim S, et al. Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis. Mol Cancer. 2016;15:68 pubmed
Pazienza V, Panebianco C, Rappa F, Memoli D, Borghesan M, Cannito S, et al. Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis. Epigenetics Chromatin. 2016;9:45 pubmed
Tsitoura E, Wells A, Karagiannis K, Lasithiotaki I, Vasarmidi E, Bibaki E, et al. MiR-185/AKT and miR-29a/collagen 1a pathways are activated in IPF BAL cells. Oncotarget. 2016;7:74569-74581 pubmed 出版商
Kim K, Jang H, Yang Y, Park K, Seo J, Shin I, et al. SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy. Sci Rep. 2016;6:35732 pubmed 出版商
Ge X, Chen S, Liu M, Liang T, Liu C. Evodiamine inhibits PDGF?BB?induced proliferation of rat vascular smooth muscle cells through the suppression of cell cycle progression and oxidative stress. Mol Med Rep. 2016;14:4551-4558 pubmed 出版商
Enterría Morales D, López López I, Lopez Barneo J, d Anglemont de Tassigny X. Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan-Neuronal Activation in the Female Mouse. PLoS ONE. 2016;11:e0164391 pubmed 出版商
Yang B, Yan P, Gong H, Zuo L, Shi Y, Guo J, et al. TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner. Am J Transl Res. 2016;8:3848-3860 pubmed
Song C, Liu B, Shi Y, Liu N, Yan Y, Zhang J, et al. MicroRNA-130a alleviates human coronary artery endothelial cell injury and inflammatory responses by targeting PTEN via activating PI3K/Akt/eNOS signaling pathway. Oncotarget. 2016;7:71922-71936 pubmed 出版商
Lee H, Wu Q, Li H, Bae G, Kim A, Ryu J. A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells. Oncol Lett. 2016;12:2912-2917 pubmed
Choi S, Lee J, Suh J, Park Y, Chung C, Park Y. Dual-function synthetic peptide derived from BMP4 for highly efficient tumor targeting and antiangiogenesis. Int J Nanomedicine. 2016;11:4643-4656 pubmed
Bewley M, Belchamber K, Chana K, Budd R, Donaldson G, Wedzicha J, et al. Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD. PLoS ONE. 2016;11:e0163139 pubmed 出版商
Beer A, Zenzmaier C, Schreinlechner M, Haas J, Dietrich M, Herz J, et al. Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member. Oncotarget. 2016;7:68721-68733 pubmed 出版商
Neubauer H, Pham D, Zebol J, Moretti P, Peterson A, Leclercq T, et al. An oncogenic role for sphingosine kinase 2. Oncotarget. 2016;7:64886-64899 pubmed 出版商
Liu D, Zhang Y, Wei Y, Liu G, Liu Y, Gao Q, et al. Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression. Oncotarget. 2016;7:65389-65402 pubmed 出版商
Zhou C, Chen X, Zeng W, Peng C, Huang G, Li X, et al. Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway. Oncotarget. 2016;7:68314-68327 pubmed 出版商
Dang F, Sun X, Ma X, Wu R, Zhang D, Chen Y, et al. Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock. Nat Commun. 2016;7:12696 pubmed 出版商
Rogers R, Morris E, Wheatley J, Archer A, McCoin C, White K, et al. Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease. Diabetes. 2016;65:3341-3351 pubmed
Moxley K, Wang L, Welm A, Bieniasz M. Short-form Ron is a novel determinant of ovarian cancer initiation and progression. Genes Cancer. 2016;7:169-81 pubmed 出版商
Xiong S, Cheng J, Klausen C, Zhao J, Leung P. TGF-β1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways. Oncotarget. 2016;7:61262-61272 pubmed 出版商
Supriya R, Tam B, Pei X, Lai C, Chan L, Yung B, et al. Doxorubicin Induces Inflammatory Modulation and Metabolic Dysregulation in Diabetic Skeletal Muscle. Front Physiol. 2016;7:323 pubmed 出版商
She Q, Gruvberger Saal S, Maurer M, Chen Y, Jumppanen M, Su T, et al. Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer. BMC Cancer. 2016;16:587 pubmed 出版商
Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, et al. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016;535:551-5 pubmed 出版商
Snapkov I, Oqvist C, Figenschau Y, Kogner P, Johnsen J, Sveinbjørnsson B. The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis. BMC Cancer. 2016;16:490 pubmed 出版商
Zheng B, Mao J, Li X, Qian L, Zhu H, Gu D, et al. Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2? expression and cell proliferation. Sci Rep. 2016;6:29415 pubmed 出版商
Steven A, Leisz S, Sychra K, Hiebl B, Wickenhauser C, Mougiakakos D, et al. Hypoxia-mediated alterations and their role in the HER-2/neuregulated CREB status and localization. Oncotarget. 2016;7:52061-52084 pubmed 出版商
Sommer A, Hermawan A, Mickler F, Ljepoja B, Knyazev P, Bräuchle C, et al. Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases. Oncotarget. 2016;7:50461-50476 pubmed 出版商
Son S, Kim S, Moon E, Kim D, Pyo S, Um S. Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma. Oncotarget. 2016;7:49334-49348 pubmed 出版商
Jang H, Hong E, Park S, Byun H, Koh D, Choi M, et al. Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. Oncol Lett. 2016;12:250-256 pubmed
Peng X, Giménez Cassina A, Petrus P, Conrad M, Rydén M, Arnér E. Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness. Sci Rep. 2016;6:28080 pubmed 出版商
Prysyazhna O, Burgoyne J, Scotcher J, Grover S, Kass D, Eaton P. Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G I? Oxidation. J Biol Chem. 2016;291:17427-36 pubmed 出版商
Tanimura Y, Aoi W, Takanami Y, Kawai Y, Mizushima K, Naito Y, et al. Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation. Physiol Rep. 2016;4: pubmed 出版商
Burger D, Turner M, Munkonda M, Touyz R. Endothelial Microparticle-Derived Reactive Oxygen Species: Role in Endothelial Signaling and Vascular Function. Oxid Med Cell Longev. 2016;2016:5047954 pubmed 出版商
Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, et al. Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation. Oncotarget. 2016;7:44142-44160 pubmed 出版商
Sharma P, Arias E, Cartee G. Protein Phosphatase 1-? Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle. Diabetes. 2016;65:2606-17 pubmed 出版商
Reis F, Branquinho J, Brandão B, Guerra B, Silva I, Frontini A, et al. Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice. Aging (Albany NY). 2016;8:1201-22 pubmed 出版商
Cheng C, Tang N, Kao S, Hsieh C. Ferulic Acid Administered at Various Time Points Protects against Cerebral Infarction by Activating p38 MAPK/p90RSK/CREB/Bcl-2 Anti-Apoptotic Signaling in the Subacute Phase of Cerebral Ischemia-Reperfusion Injury in Rats. PLoS ONE. 2016;11:e0155748 pubmed 出版商
Hu T, Wei G, Xi M, Yan J, Wu X, Wang Y, et al. Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway. Int J Mol Med. 2016;38:83-94 pubmed 出版商
Canté Barrett K, Spijkers Hagelstein J, Buijs Gladdines J, Uitdehaag J, Smits W, van der Zwet J, et al. MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia. Leukemia. 2016;30:1832-43 pubmed 出版商
Zhao J, Klausen C, Qiu X, Cheng J, Chang H, Leung P. Betacellulin induces Slug-mediated down-regulation of E-cadherin and cell migration in ovarian cancer cells. Oncotarget. 2016;7:28881-90 pubmed 出版商
Krupkova O, Handa J, Hlavna M, Klasen J, Ospelt C, Ferguson S, et al. The Natural Polyphenol Epigallocatechin Gallate Protects Intervertebral Disc Cells from Oxidative Stress. Oxid Med Cell Longev. 2016;2016:7031397 pubmed 出版商
Amir S, Simion C, Umeh Garcia M, Krig S, Moss T, Carraway K, et al. Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer. Br J Cancer. 2016;114:1125-34 pubmed 出版商
Nunes J, Zhang H, Angelopoulos N, Chhetri J, Osipo C, Grothey A, et al. ATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation. Oncotarget. 2016;7:27599-612 pubmed 出版商
Pijut S, Corbett D, Wang Y, Li J, Charnigo R, Graf G. Effect of peripheral circadian dysfunction on metabolic disease in response to a diabetogenic diet. Am J Physiol Endocrinol Metab. 2016;310:E900-11 pubmed 出版商
Komiya C, Tsuchiya K, Shiba K, Miyachi Y, Furuke S, Shimazu N, et al. Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction. PLoS ONE. 2016;11:e0151511 pubmed 出版商
Du Z, Sun T, Hacisuleyman E, Fei T, Wang X, Brown M, et al. Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nat Commun. 2016;7:10982 pubmed 出版商
Choi H, Lee K, Kim M, Lee K, Shin Y, Cho S, et al. DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis. Oncotarget. 2016;7:21775-85 pubmed 出版商
Unruh D, Unlü B, Lewis C, Qi X, Chu Z, Sturm R, et al. Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma. Oncotarget. 2016;7:25264-75 pubmed 出版商
Howe G, Xiao B, Zhao H, Al Zahrani K, Hasim M, Villeneuve J, et al. Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer. PLoS ONE. 2016;11:e0150567 pubmed 出版商
Woo S, Choi Y, Kim A, Yun Y, Shin Y, Cho S, et al. Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice. Mol Med Rep. 2016;13:2967-72 pubmed 出版商
Li R, Sun Y, Jiang A, Wu Y, Li C, Jin M, et al. Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells. Mol Med Rep. 2016;13:3190-6 pubmed 出版商
Mediavilla Varela M, Boateng K, Noyes D, Antonia S. The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts. BMC Cancer. 2016;16:176 pubmed 出版商
Tokunaga R, Imamura Y, Nakamura K, Ishimoto T, Nakagawa S, Miyake K, et al. Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma. Oncotarget. 2016;7:19748-61 pubmed 出版商
Lindqvist J, Levy Y, Pati Alam A, Hardeman E, Gregorevic P, Ochala J. Modulating myosin restores muscle function in a mouse model of nemaline myopathy. Ann Neurol. 2016;79:717-725 pubmed 出版商
Groeneveld M, Brierley G, Rocha N, Siddle K, Semple R. Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production. Sci Rep. 2016;6:21105 pubmed 出版商
Waters A, Stewart J, Atigadda V, Mroczek Musulman E, Muccio D, Grubbs C, et al. Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies. Mol Cancer Ther. 2016;15:911-21 pubmed 出版商
Urasaki Y, Pizzorno G, Le T. Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice. PLoS ONE. 2016;11:e0146994 pubmed 出版商
Salifou K, Ray S, Verrier L, Aguirrebengoa M, Trouche D, Panov K, et al. The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability. Nat Commun. 2016;7:10174 pubmed 出版商
Matalkah F, Martin E, Zhao H, Agazie Y. SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer. Breast Cancer Res. 2016;18:2 pubmed 出版商
Alén B, Leal López S, Alén M, Viaño P, García Castro V, Mosteiro C, et al. The role of the obestatin/GPR39 system in human gastric adenocarcinomas. Oncotarget. 2016;7:5957-71 pubmed 出版商
Matà R, Palladino C, Nicolosi M, Lo Presti A, Malaguarnera R, Ragusa M, et al. IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway. Oncotarget. 2016;7:7683-700 pubmed 出版商
Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki T, et al. Transcription factor LSF (TFCP2) inhibits melanoma growth. Oncotarget. 2016;7:2379-90 pubmed 出版商
SKU号 :
产品名称 :
Phospho-Akt (Ser473) Antibody
规格 :
Price-(USD) :
物种x :
H, M, R, Hm, Dm, B, Dg, Pg, (Mk, C, X, Hr)
应用 :
产品种类 :
PI3K / Akt Signaling
运输温度 :
储存温度 :
产品类型 :
分子量 :
宿主 :
靶标 :
公司总部: 美国