Zhao Y, Sun J, Li Y, Zhou X, Zhai W, Wu Y, et al. Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway. Acta Pharm Sin B. 2021;11:2835-2849 pubmed 出版商

Liu Y, Li Y, Huang S, Li Y, Xia J, Jia J, et al. Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways. Aging (Albany NY). 2021;13:21155-21190 pubmed 出版商

De Velasco M, Kura Y, Ando N, Sako N, Banno E, Fujita K, et al. Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of Pten-Deficient Prostate Cancer. Cancers (Basel). 2021;13: pubmed 出版商

Zavvarian M, Hong J, Khazaei M, Chio J, Wang J, Badner A, et al. The Protein Kinase Inhibitor Midostaurin Improves Functional Neurological Recovery and Attenuates Inflammatory Changes Following Traumatic Cervical Spinal Cord Injury. Biomolecules. 2021;11: pubmed 出版商

Gan G, Shi Z, Liu D, Zhang S, Zhu H, Wang Y, et al. 3-hydroxyanthranic acid increases the sensitivity of hepatocellular carcinoma to sorafenib by decreasing tumor cell stemness. Cell Death Discov. 2021;7:173 pubmed 出版商

Guo Y, Yu Z, Wu J, Gong H, Kesteven S, Iismaa S, et al. The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy. elife. 2021;10: pubmed 出版商

Mou S, Zhou Z, Feng H, Zhang N, Lin Z, Aiyasiding X, et al. Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway. Front Pharmacol. 2021;12:648688 pubmed 出版商

Wang X, Pei Z, Hossain A, Bai Y, Chen G. Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversion. Cancer Biol Med. 2021;: pubmed 出版商

Nakayama A, Albarrán Juárez J, Liang G, Roquid K, Iring A, Tonack S, et al. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI Insight. 2020;5: pubmed 出版商

Fine J, Kosyakovsky J, Baillargeon A, Tokarev J, Cooner J, Svitak A, et al. Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non-disease-specific pathway of functional neurologic improvement. Brain Behav. 2020;10:e01536 pubmed 出版商

Zhou L, Shao C, Xie Y, Wang N, Xu S, Luo B, et al. Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination. elife. 2020;9: pubmed 出版商

Zeng S, Bai J, Jiang H, Zhu J, Fu C, He M, et al. Treatment With Liraglutide Exerts Neuroprotection After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the PI3K/AKT/GSK3β Pathway. Front Cell Neurosci. 2019;13:585 pubmed 出版商

Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt S, Vieira Saecker A, et al. NLRP3 inflammasome activation drives tau pathology. Nature. 2019;: pubmed 出版商

van de Vlekkert D, Demmers J, Nguyen X, Campos Y, Machado E, Annunziata I, et al. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019;5:eaav3270 pubmed 出版商

Uddin G, Zhang L, Shah S, Fukushima A, Wagg C, Gopal K, et al. Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Cardiovasc Diabetol. 2019;18:86 pubmed 出版商

Yang S, Harding A, Sweeney C, Miao D, Swan G, Zhou C, et al. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019;5:eaav7999 pubmed 出版商

Chaves Pérez A, Yilmaz M, Perna C, de la Rosa S, Djouder N. URI is required to maintain intestinal architecture during ionizing radiation. Science. 2019;364: pubmed 出版商

Xu F, Xiao H, Liu R, Yang Y, Zhang M, Chen L, et al. Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt. Front Pharmacol. 2019;10:261 pubmed 出版商

Chang H, Di T, Wang Y, Zeng X, Li G, Wan Q, et al. Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance. Neurobiol Dis. 2019;127:350-361 pubmed 出版商

Bishnupuri K, Alvarado D, Khouri A, Shabsovich M, Chen B, Dieckgraefe B, et al. IDO1 and kynurenine pathway metabolites activate PI3K-Akt signaling in the neoplastic colon epithelium to promote cancer cell proliferation and inhibit apoptosis. Cancer Res. 2019;: pubmed 出版商

Ruegsegger G, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, et al. Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J. 2019;33:4458-4472 pubmed 出版商

Shen B, Vardy K, Hughes P, Tasdogan A, Zhao Z, Yue R, et al. Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass. elife. 2019;8: pubmed 出版商

Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed 出版商

Bartolomé A, Zhu C, Sussel L, Pajvani U. Notch signaling dynamically regulates adult β cell proliferation and maturity. J Clin Invest. 2019;129:268-280 pubmed 出版商

Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny Geier G, et al. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018;9:3839 pubmed 出版商

Patra D, DeLassus E, Mueller J, Abou Ezzi G, Sandell L. Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice. Biol Open. 2018;7: pubmed 出版商

Shen L, Qu X, Li H, Xu C, Wei M, Wang Q, et al. NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis. Oncogene. 2018;37:1759-1774 pubmed 出版商

Zhao Z, Jia Q, Wu M, Xie X, Wang Y, Song G, et al. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018;24:130-144 pubmed 出版商

Take K, Waki H, Sun W, Wada T, Yu J, Nakamura M, et al. CDK5 Regulatory Subunit-Associated Protein 1-like 1 Negatively Regulates Adipocyte Differentiation through Activation of Wnt Signaling Pathway. Sci Rep. 2017;7:7326 pubmed 出版商

Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:4263 pubmed 出版商

Wu X, Kosaraju J, Tam K. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3? activity in SH-SY5Y cells. Eur J Pharm Sci. 2017;110:101-108 pubmed 出版商

Suresh S, Chavalmane A, Dj V, Yarreiphang H, Rai S, Paul A, et al. A novel autophagy modulator 6-Bio ameliorates SNCA/?-synuclein toxicity. Autophagy. 2017;13:1221-1234 pubmed 出版商

Subramaniam M, Cicek M, Pitel K, Bruinsma E, Nelson Holte M, Withers S, et al. TIEG1 modulates ?-catenin sub-cellular localization and enhances Wnt signaling in bone. Nucleic Acids Res. 2017;45:5170-5182 pubmed 出版商

Shen C, Zhou J, Wang X, Yu X, Liang C, Liu B, et al. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3? Signaling Pathway. EBioMedicine. 2017;16:238-250 pubmed 出版商

Cederquist C, Lentucci C, Martinez Calejman C, Hayashi V, Orofino J, GUERTIN D, et al. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017;6:125-137 pubmed 出版商

Guo A, Lu P, Lee J, Zhen C, Chiosis G, Wang Y. HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment. Oncogene. 2017;36:3441-3449 pubmed 出版商

Chen Y, Li C, Xie H, Fan Y, Yang Z, Ma J, et al. Infiltrating mast cells promote renal cell carcinoma angiogenesis by modulating PI3K→︀AKT→︀GSK3β→︀AM signaling. Oncogene. 2017;36:2879-2888 pubmed 出版商

Wu M, Chen W, Lu Y, Zhu G, Hao L, Li Y. Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway. Nat Commun. 2017;8:13700 pubmed 出版商

Hussain R, Macklin W. Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle. J Neurosci. 2017;37:397-412 pubmed 出版商

Park J, Kim S, Yoo J, Jang J, Lee A, Oh J, et al. Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease. Mol Neurobiol. 2017;54:7706-7721 pubmed 出版商

Gómez Salinero J, López Olañeta M, Ortiz Sánchez P, Larrasa Alonso J, Gatto A, Felkin L, et al. The Calcineurin Variant CnA?1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation. Cell Chem Biol. 2016;23:1372-1382 pubmed 出版商

Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed 出版商

Tai Y, Tung L, Lin Y, Lu P, Chu P, Wang M, et al. Grb7 Protein Stability Modulated by Pin1 in Association with Cell Cycle Progression. PLoS ONE. 2016;11:e0163617 pubmed 出版商

Mercado Pimentel M, Igarashi S, Dunn A, Behbahani M, Miller C, Read C, et al. The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation. Austin J Med Oncol. 2016;3: pubmed

Drelon C, Berthon A, Sahut Barnola I, Mathieu M, Dumontet T, Rodriguez S, et al. PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development. Nat Commun. 2016;7:12751 pubmed 出版商

Li C, Lim S, Xia W, Lee H, Chan L, Kuo C, et al. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nat Commun. 2016;7:12632 pubmed 出版商

Hong X, Liu W, Song R, Shah J, Feng X, Tsang C, et al. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016;44:8855-8869 pubmed

Li L, Liu H, Wang C, Liu X, Hu F, Xie N, et al. Overexpression of ?-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma. Biomed Res Int. 2016;2016:5378567 pubmed 出版商

Hammers D, Sleeper M, Forbes S, Shima A, Walter G, Sweeney H. Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. J Am Heart Assoc. 2016;5: pubmed 出版商

Zhou A, Lin K, Zhang S, Chen Y, Zhang N, Xue J, et al. Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22. Nat Cell Biol. 2016;18:954-966 pubmed 出版商

Oh B, Kim S, Lee Y, Hong H, Kim T, Kim S, et al. Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells. Oncotarget. 2016;7:57066-57076 pubmed 出版商

Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed 出版商

Hsu Y, Chang P, Ho C, Huang Y, Shih Y, Wang C, et al. Protective effects of miR-29a on diabetic glomerular dysfunction by modulation of DKK1/Wnt/β-catenin signaling. Sci Rep. 2016;6:30575 pubmed 出版商

Metz H, Kargl J, Busch S, Kim K, Kurland B, Abberbock S, et al. Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma. Proc Natl Acad Sci U S A. 2016;113:8795-800 pubmed 出版商

Sun Z, Zhan L, Liang L, Sui H, Zheng L, Sun X, et al. ZiBu PiYin recipe prevents diabetes-associated cognitive decline in rats: possible involvement of ameliorating mitochondrial dysfunction, insulin resistance pathway and histopathological changes. BMC Complement Altern Med. 2016;16:200 pubmed 出版商

Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed 出版商

Vodicka P, Chase K, Iuliano M, Valentine D, Sapp E, Lu B, et al. Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016;5:163-74 pubmed 出版商

Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed 出版商

Kuang J, Li L, Guo L, Su Y, Wang Y, Xu Y, et al. RNF8 promotes epithelial-mesenchymal transition of breast cancer cells. J Exp Clin Cancer Res. 2016;35:88 pubmed 出版商

Xi Z, Yao M, Li Y, Xie C, Holst J, Liu T, et al. Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation. Cell Death Dis. 2016;7:e2252 pubmed 出版商

Chelko S, Asimaki A, Andersen P, Bedja D, Amat Alarcon N, Demazumder D, et al. Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016;1: pubmed 出版商

Huang Y, Lin C, Liao H, Liu C, Chen Y, Chiu W, et al. Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. Neuroscience. 2016;328:201-9 pubmed 出版商

Xu Z, Mei F, Liu H, Sun C, Zheng Z. C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. J Am Heart Assoc. 2016;5: pubmed 出版商

Yang E, Tacchelly Benites O, Wang Z, Randall M, Tian A, Benchabane H, et al. Wnt pathway activation by ADP-ribosylation. Nat Commun. 2016;7:11430 pubmed 出版商

Kim S, Choi K, Cho S, Yun S, Jeon J, Koh Y, et al. Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. Sci Rep. 2016;6:24933 pubmed 出版商

Li N, Liu S, Zhang H, Deng Z, Zhao H, Zhao Q, et al. Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles. Int J Mol Sci. 2016;17: pubmed 出版商

Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, et al. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016;7:11391 pubmed 出版商

Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed 出版商

Parameswaran R, Ramakrishnan P, Moreton S, Xia Z, Hou Y, Lee D, et al. Repression of GSK3 restores NK cell cytotoxicity in AML patients. Nat Commun. 2016;7:11154 pubmed 出版商

Hansen N, Hjort L, Broholm C, Gillberg L, Schrölkamp M, Schultz H, et al. Metabolic and Transcriptional Changes in Cultured Muscle Stem Cells from Low Birth Weight Subjects. J Clin Endocrinol Metab. 2016;101:2254-64 pubmed 出版商

Winnay J, Solheim M, Dirice E, Sakaguchi M, Noh H, Kang H, et al. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016;126:1401-12 pubmed 出版商

Gao X, Feng J, He Y, Xu F, Fan X, Huang W, et al. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci Rep. 2016;6:22999 pubmed 出版商

Li S, Wang F, Yang Y, Tiao M, Chuang J, Huang Y. Microarray Study of Pathway Analysis Expression Profile Associated with MicroRNA-29a with Regard to Murine Cholestatic Liver Injuries. Int J Mol Sci. 2016;17:324 pubmed 出版商

Santio N, Salmela M, Arola H, Eerola S, Heino J, Rainio E, et al. The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways. Exp Cell Res. 2016;342:113-24 pubmed 出版商

Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed 出版商

Katoh I, Fukunishi N, Fujimuro M, Kasai H, Moriishi K, Hata R, et al. Repression of Wnt/β-catenin response elements by p63 (TP63). Cell Cycle. 2016;15:699-710 pubmed 出版商

Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed 出版商

Cott C, Thuenauer R, Landi A, Kühn K, Juillot S, Imberty A, et al. Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation. Biochim Biophys Acta. 2016;1863:1106-18 pubmed 出版商

Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior I, et al. Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell Commun Signal. 2016;14:5 pubmed 出版商

Thornton T, Delgado P, Chen L, Salas B, Krementsov D, Fernández M, et al. Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. Nat Commun. 2016;7:10553 pubmed 出版商

Ogawa F, Murphy L, Malavasi E, O Sullivan S, Torrance H, Porteous D, et al. NDE1 and GSK3? Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking. ACS Chem Neurosci. 2016;7:553-64 pubmed 出版商

Luey B, May F. Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase/Akt pathway. Mol Cancer. 2016;15:8 pubmed 出版商

Bian Y, Yang L, Wang Z, Wang Q, Zeng L, Xu G. Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice. Neural Plast. 2015;2015:627837 pubmed 出版商

Bowser J, Blackburn M, Shipley G, Molina J, Dunner K, Broaddus R. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression. J Clin Invest. 2016;126:220-38 pubmed 出版商

Wang Y, Zhang Y, Hu W, Xie S, Gong C, Iqbal K, et al. Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation. Sci Rep. 2015;5:15709 pubmed 出版商

Leve F, Peres Moreira R, Binato R, Abdelhay E, Morgado Díaz J. LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways. PLoS ONE. 2015;10:e0139094 pubmed 出版商

Liu L, Li C, Lu Y, Zong X, Luo C, Sun J, et al. Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Sci Rep. 2015;5:14474 pubmed 出版商

Haim Y, Bluher M, Slutsky N, Goldstein N, Kloting N, Harman Boehm I, et al. Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy. 2015;11:2074-2088 pubmed 出版商

Harmeier A, Obermueller S, Meyer C, Revel F, Buchy D, Chaboz S, et al. Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers. Eur Neuropsychopharmacol. 2015;25:2049-61 pubmed 出版商

Li M, Yang S, Xing B, Ferguson B, Gulchina Y, Li Y, et al. LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment. Exp Neurol. 2015;273:190-201 pubmed 出版商

Reuther C, Heinzle V, Spampatti M, Vlotides G, de Toni E, Spöttl G, et al. Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for 'Off-Target' Effects Not Mediated by c-Met Inhibition. Neuroendocrinology. 2016;103:383-401 pubmed 出版商

Angliker N, Burri M, Zaichuk M, Fritschy J, Rüegg M. mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. Eur J Neurosci. 2015;42:2595-612 pubmed 出版商

Rodríguez Seoane C, Ramos A, Korth C, Requena J. DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway. J Neurochem. 2015;135:598-605 pubmed 出版商

Lee M, Jeong M, Lee H, Han H, Ko A, Hewitt S, et al. PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis. Nat Commun. 2015;6:7769 pubmed 出版商

Nagaoka K, Matoba T, Mao Y, Nakano Y, Ikeda G, Egusa S, et al. A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model. PLoS ONE. 2015;10:e0132451 pubmed 出版商

Metge B, Mitra A, Chen D, Shevde L, Samant R. N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Sci Rep. 2015;5:11995 pubmed 出版商

Tan X, Xue Y, Ma T, Wang X, Li J, Lan L, et al. Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment. Mol Neurodegener. 2015;10:24 pubmed 出版商

Khan K, Dô F, Marineau A, Doyon P, Clément J, Woodgett J, et al. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway. Mol Cell Biol. 2015;35:3029-43 pubmed 出版商

Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, et al. Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. EMBO Mol Med. 2015;7:1048-62 pubmed 出版商

Ching J, Amiridis S, Stylli S, Bjorksten A, Kountouri N, Zheng T, et al. The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells. Oncotarget. 2015;6:21301-14 pubmed

Zeng X, Wang H, Bai F, Zhou X, Li S, Ren L, et al. Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target. Br J Pharmacol. 2015;172:4303-18 pubmed 出版商

Petrov D, Pedrós I, Artiach G, Sureda F, Barroso E, Pallas M, et al. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochim Biophys Acta. 2015;1852:1687-99 pubmed 出版商

Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed 出版商

Lin X, Xu W, Shao M, Fan Q, Wen G, Li C, et al. Shenling Baizhu San supresses colitis associated colorectal cancer through inhibition of epithelial-mesenchymal transition and myeloid-derived suppressor infiltration. BMC Complement Altern Med. 2015;15:126 pubmed 出版商

Hotokezaka Y, Katayama I, van Leyen K, Nakamura T. GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses. Cell Death Dis. 2015;6:e1719 pubmed 出版商

Ko R, Park J, Ha H, Choi Y, Lee S. Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. Nat Commun. 2015;6:6765 pubmed 出版商

Yazlovitskaya E, Tseng H, Viquez O, Tu T, Mernaugh G, McKee K, et al. Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol Biol Cell. 2015;26:1857-74 pubmed 出版商

Schisler J, Grevengoed T, Pascual F, Cooper D, Ellis J, Paul D, et al. Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin. J Am Heart Assoc. 2015;4: pubmed 出版商

Porquet D, Andrés Benito P, Griñán Ferré C, Camins A, Ferrer I, Canudas A, et al. Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8). Age (Dordr). 2015;37:9747 pubmed 出版商

Traenkle B, Emele F, Anton R, Poetz O, Haeussler R, Maier J, et al. Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells. Mol Cell Proteomics. 2015;14:707-23 pubmed 出版商

Azimzadeh O, Sievert W, Sarioglu H, Merl Pham J, Yentrapalli R, Bakshi M, et al. Integrative proteomics and targeted transcriptomics analyses in cardiac endothelial cells unravel mechanisms of long-term radiation-induced vascular dysfunction. J Proteome Res. 2015;14:1203-19 pubmed 出版商

Maurya S, Mishra J, Abbas S, Bandyopadhyay S. Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Mol Neurobiol. 2016;53:968-82 pubmed 出版商

Cheng Y, Chen P, Chiang H, Suen C, Hwang M, Lin T, et al. Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT. Cell Death Dis. 2015;6:e1584 pubmed 出版商

Gasser J, Inuzuka H, Lau A, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol Cell. 2014;56:595-607 pubmed 出版商

Li F, Song N, Tombran Tink J, Niyibizi C. Pigment epithelium derived factor suppresses expression of Sost/Sclerostin by osteocytes: implication for its role in bone matrix mineralization. J Cell Physiol. 2015;230:1243-9 pubmed 出版商

Kim H, Park J, Won H, Lee J, Kong G. CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/β-catenin pathway. FASEB J. 2015;29:300-13 pubmed 出版商

Zaru R, Edgar A, Hanauer A, Watts C. Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells. Mol Cell Biol. 2015;35:132-40 pubmed 出版商

Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, et al. Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation. Neurobiol Aging. 2015;36:188-200 pubmed 出版商

Morris S, Carter K, Baek J, Koszarek A, Yeh M, Knoblaugh S, et al. TGF-? signaling alters the pattern of liver tumorigenesis induced by Pten inactivation. Oncogene. 2015;34:3273-82 pubmed 出版商

E L, Burns J, Swerdlow R. Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiol Aging. 2014;35:2574-2583 pubmed 出版商

Bañón Maneus E, Rovira J, Ramírez Bajo M, Moya Rull D, Hierro Garcia N, Takenaka S, et al. Wnt pathway activation in long term remnant rat model. Biomed Res Int. 2014;2014:324713 pubmed 出版商

Sarshad A, Corcoran M, Al Muzzaini B, Borgonovo Brandter L, von Euler A, Lamont D, et al. Glycogen synthase kinase (GSK) 3? phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells. PLoS Genet. 2014;10:e1004390 pubmed 出版商

Sahlberg S, Spiegelberg D, Glimelius B, Stenerlow B, Nestor M. Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PLoS ONE. 2014;9:e94621 pubmed 出版商

Wang Y, Zhou D, Chen S. SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1. Mol Endocrinol. 2014;28:935-48 pubmed 出版商

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed 出版商

Yu P, Laird A, Du X, Wu J, Won K, Yamaguchi K, et al. Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway. Mol Cancer Ther. 2014;13:1078-91 pubmed 出版商

Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed 出版商

Gonçalves V, Henriques A, Henriques A, Pereira J, Pereira J, Neves Costa A, et al. Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells. RNA. 2014;20:474-82 pubmed 出版商

Chen L, Dai J, Wang Z, Zhang H, Huang Y, Zhao Y. Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3 ? -CREB Signaling Pathway. Evid Based Complement Alternat Med. 2014;2014:506735 pubmed 出版商

Zhang Y, Zhang X, Gao L, Liu Y, Jiang D, Chen K, et al. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochim Biophys Acta. 2014;1842:232-44 pubmed 出版商

Samaan S, Tranchevent L, Dardenne E, Polay Espinoza M, Zonta E, Germann S, et al. The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways. Nucleic Acids Res. 2014;42:2197-207 pubmed 出版商

Knoblich K, Wang H, Sharma C, Fletcher A, Turley S, Hemler M. Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits ?-catenin degradation. Cell Mol Life Sci. 2014;71:1305-14 pubmed 出版商

Yu P, Yan M, Lai H, Huang R, Chou Y, Lin W, et al. Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. Int J Cancer. 2014;134:542-51 pubmed 出版商

Abrahamsson A, Geron I, Gotlib J, Dao K, Barroga C, Newton I, et al. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A. 2009;106:3925-9 pubmed 出版商

Takaichi Y, Chambers J, Takahashi K, Soeda Y, Koike R, Katsumata E, et al. Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus). Acta Neuropathol Commun. 2021;9:10 pubmed 出版商

Lin Y, Haas A, Bufe A, Parbin S, Hennecke M, Voloshanenko O, et al. Wnt10b-GSK3β-dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells. Life Sci Alliance. 2021;4: pubmed 出版商

Gonçalves V, Henriques A, Matos P, Jordan P. Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells. Oncotarget. 2020;11:4421-4437 pubmed 出版商

Takaichi Y, Chambers J, Inoue H, Ano Y, Takashima A, Nakayama H, et al. Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy. Acta Neuropathol Commun. 2020;8:86 pubmed 出版商

Tan H, Tan S. The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining α-tubulin acetylation. J Biol Chem. 2020;295:5928-5943 pubmed 出版商

Yoon S, Parnell E, Kasherman M, Forrest M, Myczek K, Premarathne S, et al. Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development. Neuron. 2019;: pubmed 出版商

Han S, Wei R, Zhang X, Jiang N, Fan M, Huang J, et al. CPT1A/2-Mediated FAO Enhancement-A Metabolic Target in Radioresistant Breast Cancer. Front Oncol. 2019;9:1201 pubmed 出版商

Moon H, Jo S, Kim H, Lee W, Won C, Lee M, et al. Loratadine, an H1 Antihistamine, Inhibits Melanogenesis in Human Melanocytes. Biomed Res Int. 2019;2019:5971546 pubmed 出版商

Trautmann M, Cyra M, Isfort I, Jeiler B, Krüger A, Grünewald I, et al. Phosphatidylinositol-3-kinase (PI3K)/Akt Signaling is Functionally Essential in Myxoid Liposarcoma. Mol Cancer Ther. 2019;18:834-844 pubmed 出版商

Nakamura M, Liu T, Husain S, Zhai P, Warren J, Hsu C, et al. Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab. 2019;29:1119-1134.e12 pubmed 出版商

Kazi A, Xiang S, Yang H, Delitto D, Trevino J, Jiang R, et al. GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors. Nat Commun. 2018;9:5154 pubmed 出版商

Bricambert J, Alves Guerra M, Esteves P, Prip Buus C, Bertrand Michel J, Guillou H, et al. The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun. 2018;9:2092 pubmed 出版商

Abd Ellah A, Voogdt C, Krappmann D, Moller P, Marienfeld R. GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10. Sci Rep. 2018;8:1352 pubmed 出版商

Xu Q, Tu J, Dou C, Zhang J, Yang L, Liu X, et al. HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma. Mol Cancer. 2017;16:178 pubmed 出版商

Maiti S, Mondal S, Satyavarapu E, Mandal C. mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation. Cell Death Dis. 2017;8:e2926 pubmed 出版商

Ji L, Jiang B, Jiang X, Charlat O, Chen A, Mickanin C, et al. The SIAH E3 ubiquitin ligases promote Wnt/?-catenin signaling through mediating Wnt-induced Axin degradation. Genes Dev. 2017;31:904-915 pubmed 出版商

Wang Y, Fu D, Su J, Chen Y, Qi C, Sun Y, et al. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells. Sci Rep. 2017;7:999 pubmed 出版商

Xu W, Liu J, Ma D, Yuan G, Lu Y, Yang Y. Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. PLoS ONE. 2017;12:e0172477 pubmed 出版商

Hoffman O, Burns N, Vadász I, Eltzschig H, Edwards M, Vohwinkel C. Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS ONE. 2017;12:e0172116 pubmed 出版商

Marzuca Nassr G, Vitzel K, De Sousa L, Murata G, Crisma A, Rodrigues Junior C, et al. Effects of high EPA and high DHA fish oils on changes in signaling associated with protein metabolism induced by hindlimb suspension in rats. Physiol Rep. 2016;4: pubmed 出版商

Fisher Wellman K, Ryan T, Smith C, Gilliam L, Lin C, Reese L, et al. A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice. Diabetes. 2016;65:3249-3261 pubmed

Lao Peregrín C, Ballesteros J, Fernández M, Zamora Moratalla A, Saavedra A, Gomez Lazaro M, et al. Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling. Addict Biol. 2017;22:1706-1718 pubmed 出版商

Gao D, Rahbar R, Fish E. CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells. Open Biol. 2016;6: pubmed 出版商

Latouche C, Natoli A, Reddy Luthmoodoo M, Heywood S, Armitage J, Kingwell B. MicroRNA-194 Modulates Glucose Metabolism and Its Skeletal Muscle Expression Is Reduced in Diabetes. PLoS ONE. 2016;11:e0155108 pubmed 出版商

Sparling D, Yu J, Kim K, Zhu C, Brachs S, Birkenfeld A, et al. Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity. Mol Metab. 2016;5:113-121 pubmed 出版商

Chen L, Huang J, Ji Y, Zhang X, Wang P, Deng K, et al. Tripartite motif 32 prevents pathological cardiac hypertrophy. Clin Sci (Lond). 2016;130:813-28 pubmed 出版商

Kaasbøll O, Moe I, Ahmed M, Stang E, Hagelin E, Attramadal H. CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury. PLoS ONE. 2016;11:e0149000 pubmed 出版商

Bai L, Yu Z, Zhang J, Yuan S, Liao C, Jeyabal P, et al. OLA1 contributes to epithelial-mesenchymal transition in lung cancer by modulating the GSK3β/snail/E-cadherin signaling. Oncotarget. 2016;7:10402-13 pubmed 出版商

Chen X, Liu Y, Zhu J, Lei S, Dong Y, Li L, et al. GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion. Sci Rep. 2016;6:20196 pubmed 出版商

Xing H, Cai Y, Wang X, Wang L, Li P, Wang G, et al. The Cytoprotective Effect of Hyperoside against Oxidative Stress Is Mediated by the Nrf2-ARE Signaling Pathway through GSK-3β Inactivation. PLoS ONE. 2015;10:e0145183 pubmed 出版商

Zhu C, Schwarz P, Abakumova I, Aguzzi A. Unaltered Prion Pathogenesis in a Mouse Model of High-Fat Diet-Induced Insulin Resistance. PLoS ONE. 2015;10:e0144983 pubmed 出版商

Shields B, Pecot C, Gao H, McMillan E, Potts M, Nagel C, et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Mol Syst Biol. 2015;11:842 pubmed 出版商

Guidotti S, Minguzzi M, Platano D, Cattini L, Trisolino G, Mariani E, et al. Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients. PLoS ONE. 2015;10:e0143865 pubmed 出版商

Chen K, Yan M, Wu P, Qing Y, Li S, Li Y, et al. Combination of remote ischemic perconditioning and remote ischemic postconditioning fails to increase protection against myocardial ischemia/reperfusion injury, compared with either alone. Mol Med Rep. 2016;13:197-205 pubmed 出版商

Martin S, DeMuth T, Miller K, Pugh T, Polewski M, Colman R, et al. Regional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction. Aging Cell. 2016;15:100-10 pubmed 出版商

Qi L, Toyoda H, Xu D, Zhou Y, Sakurai N, Amano K, et al. PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells. Cancer Cell Int. 2015;15:91 pubmed 出版商

Shen S, Guo M, Xiong Z, Yu Y, Zhao X, Zhang F, et al. AIF inhibits tumor metastasis by protecting PTEN from oxidation. EMBO Rep. 2015;16:1563-80 pubmed 出版商

Zhang H, Li Y, Hu J, Shen W, Singh M, Hou X, et al. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. PLoS ONE. 2015;10:e0138203 pubmed 出版商

Gao C, Chen G, Kuan S, Zhang D, Schlaepfer D, Hu J. FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. elife. 2015;4: pubmed 出版商

Ying X, Jing L, Ma S, Li Q, Luo X, Pan Z, et al. GSK3β mediates pancreatic cancer cell invasion in vitro via the CXCR4/MMP-2 Pathway. Cancer Cell Int. 2015;15:70 pubmed 出版商

Theodosakis N, Held M, Marzuka Alcalá A, Meeth K, Micevic G, Long G, et al. BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume. Mol Cancer Ther. 2015;14:1680-92 pubmed 出版商

Kusch A, Schmidt M, Gürgen D, Postpieszala D, Catar R, Hegner B, et al. 17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling. PLoS ONE. 2015;10:e0123385 pubmed 出版商

Yen Y, Gassen N, Zellner A, Rein T, Landgraf R, Wotjak C, et al. Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD. Front Behav Neurosci. 2015;9:67 pubmed 出版商

Newsom S, Everett A, Park S, Van Pelt D, Hinko A, Horowitz J. Lipid mixtures containing a very high proportion of saturated fatty acids only modestly impair insulin signaling in cultured muscle cells. PLoS ONE. 2015;10:e0120871 pubmed 出版商

Lappas M. GSK3β is increased in adipose tissue and skeletal muscle from women with gestational diabetes where it regulates the inflammatory response. PLoS ONE. 2014;9:e115854 pubmed 出版商

Zhang J, Wang C, Yu S, Luo Z, Chen Y, Liu Q, et al. Sevoflurane postconditioning protects rat hearts against ischemia-reperfusion injury via the activation of PI3K/AKT/mTOR signaling. Sci Rep. 2014;4:7317 pubmed 出版商

Fine J, Renner D, Forsberg A, Cameron R, Galick B, Le C, et al. Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation. Neurosci Lett. 2015;584:362-7 pubmed 出版商

Sunaga D, Tanno M, Kuno A, Ishikawa S, Ogasawara M, Yano T, et al. Accelerated recovery of mitochondrial membrane potential by GSK-3β inactivation affords cardiomyocytes protection from oxidant-induced necrosis. PLoS ONE. 2014;9:e112529 pubmed 出版商

Kim J. Brain-derived neurotrophic factor exerts neuroprotective actions against amyloid β-induced apoptosis in neuroblastoma cells. Exp Ther Med. 2014;8:1891-1895 pubmed

Yu H, Deng J, Zuo Z. High-fat diet reduces neuroprotection of isoflurane post-treatment: Role of carboxyl-terminal modulator protein-Akt signaling. Obesity (Silver Spring). 2014;22:2396-405 pubmed 出版商

Gao X, He Y, Gao L, Feng J, Xie Y, Liu X, et al. Ser9-phosphorylated GSK3? induced by 14-3-3? actively antagonizes cell apoptosis in a NF-?B dependent manner. Biochem Cell Biol. 2014;92:349-56 pubmed 出版商

Liu Z, Chen X, Song H, Wang H, Zhang G, Wang H, et al. Snail regulated by PKC/GSK-3? pathway is crucial for EGF-induced epithelial-mesenchymal transition (EMT) of cancer cells. Cell Tissue Res. 2014;358:491-502 pubmed 出版商

Vignarajan S, Xie C, Yao M, Sun Y, Simanainen U, Sved P, et al. Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A?? via AKT in prostate cancer cells. Oncotarget. 2014;5:6289-99 pubmed 出版商

Fappi A, Godoy T, Maximino J, Rizzato V, Neves J, Chadi G, et al. The effects of omega-3 fatty acid supplementation on dexamethasone-induced muscle atrophy. Biomed Res Int. 2014;2014:961438 pubmed 出版商

Shanmugam V, Ramanathan R, Lavender N, Sinari S, Chadha M, Liang W, et al. Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer. BMC Med Genomics. 2014;7:36 pubmed 出版商

Jahn S, LAW M, Corsino P, Davis B, Harrison J, Law B. Signaling mechanisms that suppress the cytostatic actions of rapamycin. PLoS ONE. 2014;9:e99927 pubmed 出版商

Lee Y, Dominy J, Choi Y, Jurczak M, Tolliday N, Camporez J, et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 2014;510:547-51 pubmed 出版商

He M, Li Y, Zhang L, Li L, Shen Y, Lin L, et al. Curcumin suppresses cell proliferation through inhibition of the Wnt/?-catenin signaling pathway in medulloblastoma. Oncol Rep. 2014;32:173-80 pubmed 出版商

Kjaersgaard G, Madsen K, Marcussen N, Jensen B. Lithium induces microcysts and polyuria in adolescent rat kidney independent of cyclooxygenase-2. Physiol Rep. 2014;2:e00202 pubmed 出版商

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014;508:541-5 pubmed 出版商

Groulx J, Giroux V, Beauséjour M, Boudjadi S, Basora N, Carrier J, et al. Integrin ?6A splice variant regulates proliferation and the Wnt/?-catenin pathway in human colorectal cancer cells. Carcinogenesis. 2014;35:1217-27 pubmed 出版商

Singh A, Chappell J, Trost R, Lin L, Wang T, Tang J, et al. Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Reports. 2013;1:532-44 pubmed 出版商

Broholm C, Mathur N, Hvid T, Grøndahl T, Frøsig C, Pedersen B, et al. Insulin signaling in skeletal muscle of HIV-infected patients in response to endurance and strength training. Physiol Rep. 2013;1:e00060 pubmed 出版商

Loiselle A, Lloyd S, Paul E, Lewis G, Donahue H. Inhibition of GSK-3? rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice. PLoS ONE. 2013;8:e81399 pubmed 出版商

Traister A, Walsh M, Aafaqi S, Lu M, Dai X, Henkleman M, et al. Mutation in integrin-linked kinase (ILK(R211A)) and heat-shock protein 70 comprise a broadly cardioprotective complex. PLoS ONE. 2013;8:e77331 pubmed 出版商

Maclean J, Hu Z, Welborn J, Song H, Rao M, Wayne C, et al. The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis. J Biol Chem. 2013;288:34809-25 pubmed 出版商

Weissinger D, Tagscherer K, Macher Göppinger S, Haferkamp A, Wagener N, Roth W. The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma. Mol Cancer. 2013;12:120 pubmed 出版商

Wiegering A, Pfann C, Uthe F, Otto C, Rycak L, Mäder U, et al. CIP2A influences survival in colon cancer and is critical for maintaining Myc expression. PLoS ONE. 2013;8:e75292 pubmed 出版商

Sierksma A, Van den Hove D, Pfau F, Philippens M, Bruno O, Fedele E, et al. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology. 2014;77:120-30 pubmed 出版商

Op den Kamp C, Langen R, Snepvangers F, de Theije C, Schellekens J, Laugs F, et al. Nuclear transcription factor ? B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia. Am J Clin Nutr. 2013;98:738-48 pubmed 出版商

Ishikawa M, Yoshida K, Okamura H, Ochiai K, Takamura H, Fujiwara N, et al. Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3? signaling pathway. Biochim Biophys Acta. 2013;1832:2035-43 pubmed 出版商

Mencarelli A, Renga B, D Amore C, Santorelli C, Graziosi L, Bruno A, et al. Dissociation of intestinal and hepatic activities of FXR and LXR? supports metabolic effects of terminal ileum interposition in rodents. Diabetes. 2013;62:3384-93 pubmed 出版商

Wang J, Chen J, Chen Y, Chen M, Hsieh C, Teng S, et al. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. PLoS ONE. 2013;8:e65586 pubmed 出版商

Maurin H, Lechat B, Dewachter I, Ris L, Louis J, Borghgraef P, et al. Neurological characterization of mice deficient in GSK3? highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase. Mol Brain. 2013;6:27 pubmed 出版商

Dufour J, Pommier A, Alves G, de Boussac H, Lours Calet C, Volle D, et al. Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell. PLoS ONE. 2013;8:e58876 pubmed 出版商

Guzman E, Maher M, Temkin A, Pitts T, Wright A. Spongiatriol inhibits nuclear factor kappa B activation and induces apoptosis in pancreatic cancer cells. Mar Drugs. 2013;11:1140-51 pubmed 出版商

Chen H, Luo Z, Dong L, Tan Y, Yang J, Feng G, et al. CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival. PLoS ONE. 2013;8:e56878 pubmed 出版商

Kim H, Woo H, Ryu J, Bok J, Kim J, Choi S, et al. Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS ONE. 2013;8:e55609 pubmed 出版商

Ikushima Y, Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, et al. Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells. Blood. 2013;121:1995-2007 pubmed 出版商

Cui G, Shan L, Hung M, Lei S, Choi I, Zhang Z, et al. A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Int J Cardiol. 2013;168:1349-59 pubmed 出版商

Li Z, Rana T. A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nat Commun. 2012;3:1085 pubmed 出版商

Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed 出版商

Woolley J, Naughton R, Stanicka J, Gough D, Bhatt L, Dickinson B, et al. H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS ONE. 2012;7:e34050 pubmed 出版商

Sawitzky M, Zeissler A, Langhammer M, Bielohuby M, Stock P, Hammon H, et al. Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice. PLoS ONE. 2012;7:e39711 pubmed 出版商

Chen Y, Guan Y, Zhang Z, Liu H, Wang S, Yu L, et al. Wnt signaling pathway is involved in the pathogenesis of amyotrophic lateral sclerosis in adult transgenic mice. Neurol Res. 2012;34:390-9 pubmed 出版商

Peña Ortega F, Solis Cisneros A, Ordaz B, Balleza Tapia H, Javier López Guerrero J. Amyloid beta 1-42 inhibits entorhinal cortex activity in the beta-gamma range: role of GSK-3. Curr Alzheimer Res. 2012;9:857-63 pubmed

Hurtado D, Molina Porcel L, Carroll J, Macdonald C, Aboagye A, Trojanowski J, et al. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. J Neurosci. 2012;32:7392-402 pubmed 出版商

Koch A, Holaska J. Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. PLoS ONE. 2012;7:e37262 pubmed 出版商

Hou J, Wang L. FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. PLoS ONE. 2012;7:e36252 pubmed 出版商

Li Y, Burns K, Arao Y, Luh C, Korach K. Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor ? and ? in vitro. Environ Health Perspect. 2012;120:1029-35 pubmed 出版商

Yoshida K, Okamura H, Ochiai K, Hoshino Y, Haneji T, Yoshioka M, et al. PKR plays a positive role in osteoblast differentiation by regulating GSK-3? activity through a ?-catenin-independent pathway. Mol Cell Endocrinol. 2012;361:99-105 pubmed 出版商

Biensø R, Ringholm S, Kiilerich K, Aachmann Andersen N, Krogh Madsen R, Guerra B, et al. GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance. Diabetes. 2012;61:1090-9 pubmed 出版商

Singh B, Xu Y, McLaughlin T, Singh V, Martinez J, Krishnan A, et al. Resistance to trophic neurite outgrowth of sensory neurons exposed to insulin. J Neurochem. 2012;121:263-76 pubmed 出版商

Reddiconto G, Toto C, Palamà I, De Leo S, de Luca E, De Matteis S, et al. Targeting of GSK3? promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells. Blood. 2012;119:2335-45 pubmed 出版商

Dan L, Klimenkova O, Klimiankou M, Klusman J, van den Heuvel Eibrink M, Reinhardt D, et al. The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. Haematologica. 2012;97:551-9 pubmed 出版商

Merabova N, Kaminski R, Krynska B, Amini S, Khalili K, Darbinyan A. JCV agnoprotein-induced reduction in CXCL5/LIX secretion by oligodendrocytes is associated with activation of apoptotic signaling in neurons. J Cell Physiol. 2012;227:3119-27 pubmed 出版商

Smith K, Tong X, Abu Yousif A, Mikulec C, Gottardi C, Fischer S, et al. UVB radiation-induced ?-catenin signaling is enhanced by COX-2 expression in keratinocytes. Mol Carcinog. 2012;51:734-45 pubmed 出版商

Kwon C, Cheng P, King I, Andersen P, Shenje L, Nigam V, et al. Notch post-translationally regulates ?-catenin protein in stem and progenitor cells. Nat Cell Biol. 2011;13:1244-51 pubmed 出版商

Zhang L, Zhou F, van Laar T, Zhang J, van Dam H, Ten Dijke P. Fas-associated factor 1 antagonizes Wnt signaling by promoting ?-catenin degradation. Mol Biol Cell. 2011;22:1617-24 pubmed 出版商

Albers J, Schulze J, Beil F, Gebauer M, Baranowsky A, Keller J, et al. Control of bone formation by the serpentine receptor Frizzled-9. J Cell Biol. 2011;192:1057-72 pubmed 出版商

Palmer M, Mahajan V, Chen J, Irvine D, Lauffenburger D. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunol Cell Biol. 2011;89:581-94 pubmed 出版商

Ghandhi S, Ming L, Ivanov V, Hei T, Amundson S. Regulation of early signaling and gene expression in the alpha-particle and bystander response of IMR-90 human fibroblasts. BMC Med Genomics. 2010;3:31 pubmed 出版商

MacNeil L, Melov S, Hubbard A, Baker S, Tarnopolsky M. Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. PLoS ONE. 2010;5:e10695 pubmed 出版商

Bhandari D, Seo K, Roh K, Jung J, Kang S, Kang K. REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells. PLoS ONE. 2010;5:e10493 pubmed 出版商

Gujral T, MacBeath G. A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. PLoS ONE. 2010;5:e10024 pubmed 出版商

Perez Costas E, Gandy J, Melendez Ferro M, Roberts R, Bijur G. Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS ONE. 2010;5:e8911 pubmed 出版商

Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed 出版商

Holden P, Horton W. Crude subcellular fractionation of cultured mammalian cell lines. BMC Res Notes. 2009;2:243 pubmed 出版商

Wu M, Katta A, Gadde M, Liu H, Kakarla S, Fannin J, et al. Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention. PLoS ONE. 2009;4:e6430 pubmed 出版商

Mizuarai S, Kawagishi A, Kotani H. Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines. Mol Cancer. 2009;8:44 pubmed 出版商

Farina A, Bong Y, Feltes C, Byers S. Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells. PLoS ONE. 2009;4:e4797 pubmed 出版商

Guertin D, Stevens D, Saitoh M, Kinkel S, Crosby K, Sheen J, et al. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell. 2009;15:148-59 pubmed 出版商

Ahn S, Byun K, Kim D, Lee K, Yoo J, Kim S, et al. Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PLoS ONE. 2008;3:e3917 pubmed 出版商

Wang J, Wang X, Gong W, Mi B, Liu S, Jiang B. Increased expression of beta-catenin, phosphorylated glycogen synthase kinase 3beta, cyclin D1, and c-myc in laterally spreading colorectal tumors. J Histochem Cytochem. 2009;57:363-71 pubmed 出版商

Laguë M, Paquet M, Fan H, Kaartinen M, Chu S, Jamin S, et al. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis. 2008;29:2062-72 pubmed 出版商