产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
切断的胱氨酸-天冬氨酸蛋白酶8(Asp391)(18C8)兔单克隆抗体
目录 :
9496
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
18C8
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
文章摘录数: 54
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 1i
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5c
Chiu C, Weng Y, Huang Y, Chen R, Liu Y, Yeh T, et al. (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model. Cell Death Dis. 2020;11:1018 pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, et al. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma. Theranostics. 2020;10:3351-3365 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1e
Wang R, Yu R, Zhu C, Lin H, Lu X, Wang H. Tubulin detyrosination promotes human trophoblast syncytium formation. J Mol Cell Biol. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 s1a
Greer Y, Gilbert S, Gril B, Narwal R, Peacock Brooks D, Tice D, et al. MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer. Breast Cancer Res. 2019;21:27 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Jiang X, Bao Y, Liu H, Kou X, Zhang Z, Sun F, et al. VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene. 2017;36:6850-6862 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6a
Sun J, Zhang X, Sun Y, Tang Z, Guo D. Effects of Hylomecon vernalis ethanol extracts on cell cycle and apoptosis of colon cancer cells. Mol Med Rep. 2017;15:3485-3492 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Jelinek M, Kabelova A, Srámek J, Seitz J, Ojima I, Kovar J. Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells. Anticancer Res. 2017;37:1581-1590 pubmed
  • 免疫印迹; 人类; 图 2b
Ma W, Tummers B, van Esch E, Goedemans R, Melief C, Meyers C, et al. Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFN?- and TNF?-Mediated Antiproliferative Effects and Necroptosis. Front Immunol. 2016;7:496 pubmed
  • 免疫组化-石蜡切片; 人类; 1:50; 图 7
  • 免疫印迹; 人类; 1:1000; 图 s15
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed 出版商
  • 免疫印迹; 人类; 图 5g
Wu J, Lei H, Zhang J, Chen X, Tang C, Wang W, et al. Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation. Oncotarget. 2016;7:58995-59005 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Cheng Y, Huang C, Lee Y, Tien L, Ku W, Chien R, et al. Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells. Sci Rep. 2016;6:30314 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Helmke C, Raab M, Rodel F, Matthess Y, Oellerich T, Mandal R, et al. Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8. Cell Res. 2016;26:914-34 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Choi H, Kim M, Choi Y, Shin Y, Cho S, Ko S. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med. 2016;16:122 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Gao X, Feng J, He Y, Xu F, Fan X, Huang W, et al. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci Rep. 2016;6:22999 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Natarelli L, Ranaldi G, Leoni G, Roselli M, Guantario B, Comitato R, et al. Nanomolar Caffeic Acid Decreases Glucose Uptake and the Effects of High Glucose in Endothelial Cells. PLoS ONE. 2015;10:e0142421 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Shen W, Chang A, Wang J, Zhou W, Gao R, Li J, et al. TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis. 2015;4:e173 pubmed 出版商
  • 免疫印迹; 人类
Li X, Liang Q, Liu W, Zhang N, Xu L, Zhang X, et al. Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway. Oncogene. 2016;35:2453-64 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. 2015;2:396-405 pubmed
  • 免疫印迹; 人类; 图 s5a
Yang N, Gilman P, Mirzayans R, Sun X, Touret N, Weinfeld M, et al. Characterization of the apoptotic response induced by the cyanine dye D112: a potentially selective anti-cancer compound. PLoS ONE. 2015;10:e0125381 pubmed 出版商
  • 免疫印迹; 人类
Yanagi T, Shi R, Aza Blanc P, Reed J, Matsuzawa S. PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines. PLoS ONE. 2015;10:e0119404 pubmed 出版商
  • 免疫印迹; 人类
Shen X, Sun W, Shi Y, Xing Z, Su X. Altered viral replication and cell responses by inserting microRNA recognition element into PB1 in pandemic influenza A virus (H1N1) 2009. Mediators Inflamm. 2015;2015:976575 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Long J, Schoonen P, Graczyk D, O Prey J, Ryan K. p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene. 2015;34:5152-62 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 8A
Silva V, Plooster M, Leung J, Cassimeris L. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell Cycle. 2015;14:1070-81 pubmed 出版商
  • 免疫印迹; 人类; 1:10; 图 4
Kang C, Lin J, Xu Z, Kumar S, Herr A. Single-cell Western blotting after whole-cell imaging to assess cancer chemotherapeutic response. Anal Chem. 2014;86:10429-36 pubmed 出版商
  • 免疫印迹; 人类
Zhang S, Tang W, Weng S, Liu X, Rao B, Gu J, et al. Apollon modulates chemosensitivity in human esophageal squamous cell carcinoma. Oncotarget. 2014;5:7183-97 pubmed
  • 免疫印迹; 人类
Derangère V, Chevriaux A, Courtaut F, Bruchard M, Berger H, Chalmin F, et al. Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells. Cell Death Differ. 2014;21:1914-24 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, et al. P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway. PLoS ONE. 2014;9:e94645 pubmed 出版商
  • 流式细胞仪; 人类
  • 免疫印迹; 人类
Villa Morales M, Cobos M, González Gugel E, Alvarez Iglesias V, Martinez B, Piris M, et al. FAS system deregulation in T-cell lymphoblastic lymphoma. Cell Death Dis. 2014;5:e1110 pubmed 出版商
  • 免疫印迹; 人类
Matthess Y, Raab M, Knecht R, Becker S, Strebhardt K. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis. Mol Oncol. 2014;8:596-608 pubmed 出版商
  • 流式细胞仪; 人类
Pavet V, Shlyakhtina Y, He T, Ceschin D, Kohonen P, Perala M, et al. Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells. Cell Death Dis. 2014;5:e1043 pubmed 出版商
  • 免疫印迹; 人类
Chopra A, Anderson A, Giardina C. Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem. 2014;289:2978-91 pubmed 出版商
  • 免疫印迹; 人类
Linderoth E, Pilia G, Mahajan N, Ferby I. Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death. J Biol Chem. 2013;288:32922-31 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Sung M, Giannakakou P. BRCA1 regulates microtubule dynamics and taxane-induced apoptotic cell signaling. Oncogene. 2014;33:1418-28 pubmed 出版商
  • 免疫印迹; 人类
Han J, Soletti R, Sadarangani A, Sridevi P, Ramirez M, Eckmann L, et al. Nuclear expression of ?-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013;11:207-18 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Giansanti V, Rodriguez G, Savoldelli M, Gioia R, Forlino A, Mazzini G, et al. Characterization of stress response in human retinal epithelial cells. J Cell Mol Med. 2013;17:103-15 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
  • 免疫印迹; 人类; 1:1000
Gauster M, Siwetz M, Huppertz B. Fusion of villous trophoblast can be visualized by localizing active caspase 8. Placenta. 2009;30:547-50 pubmed 出版商
Chen C, Dienhart J, Bolton E. Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. PLoS ONE. 2016;11:e0156145 pubmed 出版商
Lam W, Jiang Z, Guan F, Huang X, Hu R, Wang J, et al. PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment. Sci Rep. 2015;5:9384 pubmed 出版商
Knievel J, Schulz W, Greife A, Hader C, Lübke T, Schmitz I, et al. Multiple mechanisms mediate resistance to sorafenib in urothelial cancer. Int J Mol Sci. 2014;15:20500-17 pubmed 出版商
Shu Q, Li W, Li H, Sun G. Vasostatin inhibits VEGF-induced endothelial cell proliferation, tube formation and induces cell apoptosis under oxygen deprivation. Int J Mol Sci. 2014;15:6019-30 pubmed 出版商
Franco R, Bortner C, Schmitz I, Cidlowski J. Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1. Apoptosis. 2014;19:117-34 pubmed 出版商
Peter B, Cerny Reiterer S, Hadzijusufovic E, Schuch K, Stefanzl G, Eisenwort G, et al. The pan-Bcl-2 blocker obatoclax promotes the expression of Puma, Noxa, and Bim mRNA and induces apoptosis in neoplastic mast cells. J Leukoc Biol. 2014;95:95-104 pubmed 出版商
Foreman K, Jesse J, Kuo P, Gupta G. Emetine dihydrochloride: a novel therapy for bladder cancer. J Urol. 2014;191:502-9 pubmed 出版商
Gao X, Lin J, Ning Q, Gao L, Yao Y, Zhou J, et al. A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells. PLoS ONE. 2013;8:e55481 pubmed 出版商
Thomé C, Dos Santos G, Ferreira G, Scheucher P, Izumi C, Leopoldino A, et al. Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity. Mol Cell Proteomics. 2012;11:1898-912 pubmed 出版商
Stutz N, Johnson R, Wood G. The Fas apoptotic pathway in cutaneous T-cell lymphomas: frequent expression of phenotypes associated with resistance to apoptosis. J Am Acad Dermatol. 2012;67:1327.e1-10 pubmed 出版商
Jinesh G G, Chunduru S, Kamat A. Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-? but not through TRAIL and FasL. J Leukoc Biol. 2012;92:233-44 pubmed 出版商
Ghanim V, Herrmann H, Heller G, Peter B, Hadzijusufovic E, Blatt K, et al. 5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand. Blood. 2012;119:4242-52 pubmed 出版商
D Agostino L, Giordano A. A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma. Oncotarget. 2011;2:1055-74 pubmed
Henrich C, Thomas C, Brooks A, Booth N, Lowery E, Pompei R, et al. Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis. Apoptosis. 2012;17:79-89 pubmed 出版商
Biton S, Ashkenazi A. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-? feedforward signaling. Cell. 2011;145:92-103 pubmed 出版商
Kim K, Lange T, Singh R, Brard L. Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cells. BMC Cancer. 2010;10:72 pubmed 出版商
Wu Y, Alvarez M, Slamon D, Koeffler P, Vadgama J. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer. 2010;10:32 pubmed 出版商
产品信息
SKU号 :
9496S
产品名称 :
切断的胱氨酸-天冬氨酸蛋白酶8(Asp391)(18C8)兔单克隆抗体
规格 :
100微升
Price-(USD) :
274美元
物种x :
H
应用 :
流式细胞仪
产品种类 :
凋亡
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
18, 41, 43
宿主 :
靶标 :
Casp8(Asp374)切断的
最初蛋白 :
Casp8
别名 :
ALPS2B,Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,CASP-8,CASP8,Caspase-8,Caspase-8 subunit p10,Caspase-8 subunit p18,FADD-homologous ICE/ced-3-like protease,FADD-like ICE,FLICE,FLJ17672,ICE-like apoptotic protease 5,MACH,MACH-alpha-1/2/3 protein,MACH-beta-1/2/3/4 protein,MCH5,MGC78473,MORT1-associated ced-3 homolog,caspase 8, apoptosis-related cysteine peptidase,caspase 8, apoptosis-related cysteine protease
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。