产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
Smad3(C67H9)兔单克隆抗体
目录 :
9523
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
C67H9
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, proximity ligation assay
文章摘录数: 110
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 6a
Jacquet M, Hervouet E, Baudu T, Herfs M, Parratte C, Feugeas J, et al. GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback. Biology (Basel). 2021;10: pubmed 出版商
  • 免疫印迹; 人类; 图 5f
  • 免疫印迹; 大鼠; 图 3b
Shi Y, Hu Y, Wang Y, Ma X, Tang L, Tao M, et al. Blockade of Autophagy Prevents the Development and Progression of Peritoneal Fibrosis. Front Pharmacol. 2021;12:724141 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 6a
  • 免疫印迹; 小鼠; 1:1000; 图 2d
Savorani C, Malinverno M, Seccia R, Maderna C, Giannotta M, Terreran L, et al. A dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition. J Cell Sci. 2021;134: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s9d
Matsuzawa T, Morita M, Shimane A, Otsuka R, Mei Y, Irie F, et al. Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis. J Biol Chem. 2021;:101006 pubmed 出版商
  • 免疫印迹; 牛; 1:1000; 图 3a
Chen F, Sheng L, Xu C, Li J, Ali I, Li H, et al. Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation. Front Cell Dev Biol. 2021;9:676789 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5e
Bruce J, To K, Lui V, Chung G, Chan Y, Tsang C, et al. Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape. Nat Commun. 2021;12:4193 pubmed 出版商
  • 免疫印迹; 小鼠; 1:250; 图 7c
Barbé C, Loumaye A, Lause P, Ritvos O, Thissen J. p21-Activated Kinase 1 Is Permissive for the Skeletal Muscle Hypertrophy Induced by Myostatin Inhibition. Front Physiol. 2021;12:677746 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 14g
Hsieh Y, Lee K, Lei H, Lan K, Huo T, Lin Y, et al. (Pro)renin Receptor Knockdown Attenuates Liver Fibrosis Through Inactivation of ERK/TGF-β1/SMAD3 Pathway. Cell Mol Gastroenterol Hepatol. 2021;12:813-838 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5b
Niu B, Liu J, Lv B, Lin J, Li X, Wu C, et al. Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis. Nat Commun. 2021;12:2809 pubmed 出版商
  • 免疫印迹; 人类; 图 s9c
Fang W, Sofia Acevedo D, Smart C, Zinda B, Alissa N, Warren K, et al. Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progression. Sci Rep. 2021;11:8708 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 6e
Meng K, Cai H, Cai S, Hong Y, Zhang X. Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats. Front Cell Dev Biol. 2021;9:644160 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Nam B, Park H, Lee Y, Oh Y, Park J, Kim S, et al. TGFβ1 Suppressed Matrix Mineralization of Osteoblasts Differentiation by Regulating SMURF1-C/EBPβ-DKK1 Axis. Int J Mol Sci. 2020;21: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6c
Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, et al. Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis. Front Immunol. 2020;11:1598 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Shoemaker L, McCormick A, Allen B, Chang S. Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations. Clin Transl Med. 2020;10:e99 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6b
Chakrabarti M, Al Sammarraie N, Gebere M, Bhattacharya A, Chopra S, Johnson J, et al. Transforming Growth Factor Beta3 is Required for Cardiovascular Development. J Cardiovasc Dev Dis. 2020;7: pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5c
Yang L, Han B, Zhang M, Wang Y, Tao K, Zhu M, et al. Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways. Front Pharmacol. 2020;11:165 pubmed 出版商
  • 免疫印迹; 人类; 1:100; 图 5c
Wang X, Lu Q, Fei X, Zhao Y, Shi B, Li C, et al. Expression and Prognostic Value of Id-4 in Patients with Esophageal Squamous Cell Carcinoma. Onco Targets Ther. 2020;13:1225-1234 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6a
Ye D, Zhu J, Zhao Q, Ma W, Xiao Y, Xu G, et al. LMP1 Up-regulates Calreticulin to Induce Epithelial-mesenchymal Transition via TGF-β/Smad3/NRP1 Pathway in Nasopharyngeal Carcinoma Cells. J Cancer. 2020;11:1257-1269 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3c
Cheng X, Haeberle S, Luca Shytaj I, Gama Brambila R, Theobald J, Ghafoory S, et al. NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice. Commun Biol. 2020;3:10 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s9d
Lin F, Meng X, Guo Y, Cao W, Liu W, Xia Q, et al. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Sci Adv. 2019;5:eaax1608 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4g
Gal H, Lysenko M, Stroganov S, Vadai E, Youssef S, Tzadikevitch Geffen K, et al. Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019;38:e100849 pubmed 出版商
  • 免疫印迹; 人类; 1:750; 图 5e
Minuesa G, Albanese S, Xie W, Kazansky Y, Worroll D, Chow A, et al. Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 2019;10:2691 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3b
Tsai C, Tsai C, Yi J, Kao H, Huang Y, Wang C, et al. Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. Sci Rep. 2019;9:5197 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4c
Li J, Wang Y, Ma M, Jiang S, Zhang X, Zhang Y, et al. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling. EBioMedicine. 2019;40:43-55 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
MacFarlane E, Parker S, Shin J, Kang B, Ziegler S, Creamer T, et al. Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome. J Clin Invest. 2019;129:659-675 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5a
Peng J, Liang S, Li L. sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 2019;41:224-234 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 s2
Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, et al. miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling. Nat Commun. 2018;9:2418 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Zhao H, Klausen C, Li Y, Zhu H, Wang Y, Leung P. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling. Cell Death Dis. 2018;9:174 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5b
Zhang R, Wu Y, Xie F, Zhong Y, Wang Y, Xu M, et al. RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke. Cell Death Differ. 2018;25:1503-1516 pubmed 出版商
  • 免疫印迹; 人类; 图 s6c
Schwab A, Siddiqui A, Vazakidou M, Napoli F, Böttcher M, Menchicchi B, et al. Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells. Cancer Res. 2018;78:1604-1618 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2c
Bajikar S, Wang C, Borten M, Pereira E, Atkins K, Janes K. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. Dev Cell. 2017;43:418-435.e13 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3d
  • 免疫印迹; 人类; 图 2f
Dufton N, Peghaire C, Osuna Almagro L, Raimondi C, Kalna V, Chuahan A, et al. Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis. Nat Commun. 2017;8:895 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5c
Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, et al. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017;214:1453-1469 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1c
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 8b
Chatterjee A, Kosmacek E, Oberley Deegan R. MnTE-2-PyP Treatment, or NOX4 Inhibition, Protects against Radiation-Induced Damage in Mouse Primary Prostate Fibroblasts by Inhibiting the TGF-Beta 1 Signaling Pathway. Radiat Res. 2017;187:367-381 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5b
Xu Z, Greenblatt M, Yan G, Feng H, Sun J, Lotinun S, et al. SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nat Commun. 2017;8:14570 pubmed 出版商
  • 免疫印迹; 人类; 图 7c
He S, Cao Y, Xie P, Dong G, Zhang L. The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function. Sci Rep. 2017;7:41364 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6b
Gopal S, Veracini L, Grall D, Butori C, Schaub S, Audebert S, et al. Fibronectin-guided migration of carcinoma collectives. Nat Commun. 2017;8:14105 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 8a
Choi S, Piao Z, Jin L, Kim J, Kim G, Ryu Y, et al. Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. PLoS ONE. 2016;11:e0167340 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Bryson B, Junk D, Cipriano R, Jackson M. STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle. 2017;16:319-334 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7d
Zhu L, Gómez Durán A, Saretzki G, Jin S, Tilgner K, Melguizo Sanchís D, et al. The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages. J Cell Biol. 2016;215:187-202 pubmed
  • 染色质免疫沉淀 ; 小鼠; 图 5b
Wang W, Song B, Anbarchian T, Shirazyan A, Sadik J, Lyons K. Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016;12:e1006352 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2a
Yang P, Schmit B, Fu C, Desart K, Oh S, Berceli S, et al. Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events. Sci Rep. 2016;6:35444 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3d
Queisser A, Hagedorn S, Wang H, Schaefer T, Konantz M, Alavi S, et al. Ecotropic viral integration site 1, a novel oncogene in prostate cancer. Oncogene. 2017;36:1573-1584 pubmed 出版商
  • 免疫印迹; 大鼠; 图 5
Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-?-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;37:1041-1051 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s5
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Libertini S, et al. Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nat Commun. 2016;7:12493 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 s1b
Elsafadi M, Manikandan M, Dawud R, Alajez N, Hamam R, Alfayez M, et al. Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization. Cell Death Dis. 2016;7:e2321 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3d
Kim D, Chang M, Yoon C, Middeldorp J, Martinez O, Byeon S, et al. Epstein-Barr virus BARF1-induced NFκB/miR-146a/SMAD4 alterations in stomach cancer cells. Oncotarget. 2016;7:82213-82227 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3e
Kang L, Zhang D, Ma C, Zhang J, Jia K, Liu J, et al. Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation. Sci Rep. 2016;6:27460 pubmed 出版商
  • 免疫印迹; 人类; 图 4f
Oh T, Wang S, Acharya B, Goode J, Graham J, Clarke C, et al. The Nuclear Receptor, ROR?, Regulates Pathways Necessary for Breast Cancer Metastasis. EBioMedicine. 2016;6:59-72 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Kurimoto R, Iwasawa S, Ebata T, Ishiwata T, Sekine I, Tada Y, et al. Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation. Int J Oncol. 2016;48:1825-36 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s10
Chang H, Liu Y, Xue M, Liu H, Du S, Zhang L, et al. Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition. Nucleic Acids Res. 2016;44:2514-27 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1a
Yang W, Deng Y, Hsieh Y, Wu K, Kuo M. Thrombin Activates Latent TGF?1 via Integrin ?v?1 in Gingival Fibroblasts. J Dent Res. 2016;95:939-45 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 4
Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, et al. STAT3 selectively interacts with Smad3 to antagonize TGF-β signalling. Oncogene. 2016;35:4388-98 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Huan C, Yang T, Liang J, Xie T, Cheng L, Liu N, et al. Methylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo. Sci Rep. 2015;5:14910 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2
Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, et al. GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nat Commun. 2015;6:8266 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7
Zhou X, Tao Y, Liang C, Zhang Y, Li H, Chen Q. BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype. Int J Mol Sci. 2015;16:20344-59 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Lee S, Litan A, Li Z, Graves B, Lindsey S, Barwe S, et al. Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity. Mol Cancer. 2015;14:159 pubmed 出版商
  • 免疫印迹; 人类
Faura Tellez G, Vandepoele K, Brouwer U, Koning H, Elderman R, Hackett T, et al. Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription. Am J Physiol Lung Cell Mol Physiol. 2015;309:L725-35 pubmed 出版商
  • proximity ligation assay; 小鼠; 图 s12
  • 染色质免疫沉淀 ; 小鼠; 图 s15
Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu Kaoud N, Halabi N, et al. Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche. J Transl Med. 2015;13:27 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 7
Tontonoz P, Cortez Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, et al. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015;35:1125-38 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 7j
  • 免疫印迹; 小鼠; 图 7h
  • 免疫印迹; 人类; 图 s3g
Li Q, Zou J, Wang M, Ding X, Chepelev I, Zhou X, et al. Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation. Nat Commun. 2014;5:5780 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Menon M, Chuang P, Li Z, Wei C, Zhang W, Luan Y, et al. Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis. J Clin Invest. 2015;125:208-21 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Zhang M, Zhang J, Liu S, Wang Q, Lin G, Qiu R, et al. NS5ATP9 suppresses activation of human hepatic stellate cells, possibly via inhibition of Smad3/phosphorylated-Smad3 expression. Inflammation. 2015;38:278-89 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Matsuyama M, Nomori A, Nakakuni K, Shimono A, Fukushima M. Secreted Frizzled-related protein 1 (Sfrp1) regulates the progression of renal fibrosis in a mouse model of obstructive nephropathy. J Biol Chem. 2014;289:31526-33 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2,3
Flanders K, Heger C, Conway C, Tang B, Sato M, Dengler S, et al. Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections. J Histochem Cytochem. 2014;62:846-63 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Watatani H, Maeshima Y, Hinamoto N, Yamasaki H, Ujike H, Tanabe K, et al. Vasohibin-1 deficiency enhances renal fibrosis and inflammation after unilateral ureteral obstruction. Physiol Rep. 2014;2: pubmed 出版商
  • 免疫印迹; 大鼠
Yi X, Li X, Zhou Y, Ren S, Wan W, Feng G, et al. Hepatocyte growth factor regulates the TGF-?1-induced proliferation, differentiation and secretory function of cardiac fibroblasts. Int J Mol Med. 2014;34:381-90 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 1:50; 图 1d
Feuerborn A, Mathow D, Srivastava P, Gretz N, Grone H. Basonuclin-1 modulates epithelial plasticity and TGF-?1-induced loss of epithelial cell integrity. Oncogene. 2015;34:1185-95 pubmed 出版商
  • 免疫印迹; 小鼠
Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa Ishizawa Y, et al. Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction. PLoS ONE. 2014;9:e89355 pubmed 出版商
  • 免疫印迹; 大鼠
Beaudoin M, Snook L, Arkell A, Stefanson A, Wan Z, Simpson J, et al. Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats. Obesity (Silver Spring). 2014;22:1632-42 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Holtzhausen A, Golzio C, How T, Lee Y, Schiemann W, Katsanis N, et al. Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. FASEB J. 2014;28:1248-67 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 7
Das R, Xu S, Quan X, Nguyen T, Kong I, Chung C, et al. Upregulation of mitochondrial Nox4 mediates TGF-?-induced apoptosis in cultured mouse podocytes. Am J Physiol Renal Physiol. 2014;306:F155-67 pubmed 出版商
  • 免疫印迹; 人类
Sun J, He H, Pillai S, Xiong Y, Challa S, Xu L, et al. GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion. J Biol Chem. 2013;288:36971-82 pubmed 出版商
  • 免疫印迹; 小鼠
Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, et al. EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature. 2013;498:492-6 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
  • 免疫印迹; 人类
Sakaki Yumoto M, Liu J, Ramalho Santos M, Yoshida N, Derynck R. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem. 2013;288:18546-60 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类; 图 4
Cigna N, Farrokhi Moshai E, Brayer S, Marchal Sommé J, Wemeau Stervinou L, Fabre A, et al. The hedgehog system machinery controls transforming growth factor-?-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis. Am J Pathol. 2012;181:2126-37 pubmed 出版商
Paw M, Wnuk D, Kądziołka D, Sęk A, Lasota S, Czyz J, et al. Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization. Int J Mol Sci. 2018;19: pubmed 出版商
Kasetti R, Maddineni P, Patel P, Searby C, Sheffield V, Zode G. Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension. J Biol Chem. 2018;293:9854-9868 pubmed 出版商
Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, et al. Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding. Biomed Res Int. 2018;2018:3293584 pubmed 出版商
Wang Y, Zhang X, Huang H, Xia Y, Yao Y, Mak A, et al. Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling. elife. 2017;6: pubmed 出版商
Bernard K, Logsdon N, Benavides G, SANDERS Y, Zhang J, Darley Usmar V, et al. Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation. J Biol Chem. 2018;293:1218-1228 pubmed 出版商
Frick C, Yarka C, Nunns H, Goentoro L. Sensing relative signal in the Tgf-?/Smad pathway. Proc Natl Acad Sci U S A. 2017;114:E2975-E2982 pubmed 出版商
Junk D, Bryson B, Smigiel J, Parameswaran N, Bartel C, Jackson M. Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. Oncogene. 2017;36:4001-4013 pubmed 出版商
Zieba J, Zhang W, Chong J, Forlenza K, Martin J, Heard K, et al. A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis. Sci Rep. 2017;7:41803 pubmed 出版商
Han C, Koo J, Kim S, Gardenghi S, Rivella S, Strnad P, et al. Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt. Nat Commun. 2016;7:13817 pubmed 出版商
Chung H, Ryu D, Kim K, Chang J, Kim Y, Yi H, et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017;216:149-165 pubmed 出版商
Zhao B, Guan H, Liu J, Zheng Z, Zhou Q, Zhang J, et al. Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-?1/Smad3 pathway. Int J Mol Med. 2017;39:153-159 pubmed 出版商
Seo E, Kim W, Hur J, Kim H, Nam S, Choi A, et al. The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis. Sci Rep. 2016;6:31931 pubmed 出版商
Liu Z, Ning G, Xu R, Cao Y, Meng A, Wang Q. Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. Nat Commun. 2016;7:12603 pubmed 出版商
Sun S, Liu D, Deng Y, Zhang X, Wan D, Xi B, et al. SIX1 coordinates with TGF? signals to induce epithelial-mesenchymal transition in cervical cancer. Oncol Lett. 2016;12:1271-1278 pubmed
Rodríguez Nieves J, Patalano S, Almanza D, Gharaee Kermani M, Macoska J. CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling. PLoS ONE. 2016;11:e0159490 pubmed 出版商
Xiong S, Klausen C, Cheng J, Leung P. Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling. Oncotarget. 2016;7:40060-40072 pubmed 出版商
Chen J, Raju G, Jogunoori W, Menon V, Majumdar A, Chen J, et al. Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas. PLoS ONE. 2016;11:e0153933 pubmed 出版商
Xiong S, Klausen C, Cheng J, Zhu H, Leung P. Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling. Oncotarget. 2015;6:31659-73 pubmed 出版商
Jeong M, Kim S, Kang H, Park K, Park W, Yang S, et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. PLoS ONE. 2015;10:e0136236 pubmed 出版商
Fang W, Mafuvadze B, Yao M, Zou A, Portsche M, Cheng N. TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms. PLoS ONE. 2015;10:e0135063 pubmed 出版商
Thomas A, Eijgelaar W, Daemen M, Newby A. Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. PLoS ONE. 2015;10:e0128163 pubmed 出版商
Yan B, Guo Q, Nan X, Wang Z, Yin Z, Yi L, et al. Micro-ribonucleic acid 29b inhibits cell proliferation and invasion and enhances cell apoptosis and chemotherapy effects of cisplatin via targeting of DNMT3b and AKT3 in prostate cancer. Onco Targets Ther. 2015;8:557-65 pubmed 出版商
Li Y, Klausen C, Cheng J, Zhu H, Leung P. Activin A, B, and AB increase human trophoblast cell invasion by up-regulating N-cadherin. J Clin Endocrinol Metab. 2014;99:E2216-25 pubmed 出版商
Kasai A, Ishimaru Y, Higashino K, Kobayashi K, Yamamuro A, Yoshioka Y, et al. Inhibition of apelin expression switches endothelial cells from proliferative to mature state in pathological retinal angiogenesis. Angiogenesis. 2013;16:723-34 pubmed 出版商
Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, et al. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013;19:421-8 pubmed 出版商
Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, et al. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. J Immunol. 2013;190:3153-62 pubmed 出版商
Nakamura K, Nakano S, Miyoshi T, Yamanouchi K, Nishihara M. Loss of SPARC in mouse skeletal muscle causes myofiber atrophy. Muscle Nerve. 2013;48:791-9 pubmed 出版商
Sarközi R, Flucher K, Haller V, Pirklbauer M, Mayer G, Schramek H. Oncostatin M inhibits TGF-?1-induced CTGF expression via STAT3 in human proximal tubular cells. Biochem Biophys Res Commun. 2012;424:801-6 pubmed 出版商
Michael D, Salter R, Ramji D. TGF-? inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2. Biochim Biophys Acta. 2012;1822:1608-16 pubmed 出版商
Xu B, Chen H, Xu W, Zhang W, Buckley S, Zheng S, et al. Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2012;303:L89-96 pubmed 出版商
Louafi F, Martinez Nunez R, Sanchez Elsner T. MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}. J Biol Chem. 2010;285:41328-36 pubmed 出版商
Li Q, Pangas S, Jorgez C, Graff J, Weinstein M, Matzuk M. Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo. Mol Cell Biol. 2008;28:7001-11 pubmed 出版商
产品信息
SKU号 :
9523S
产品名称 :
Smad3(C67H9)兔单克隆抗体
规格 :
100微升
Price-(USD) :
235美元
物种x :
H, M, R, Mk, (X, Z, B)
应用 :
染色质免疫沉淀
产品种类 :
发育生物学
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
52
宿主 :
靶标 :
Smad3
最初蛋白 :
Smad3
别名 :
DKFZp586N0721,DKFZp686J10186,HSPC193,HsT17436,JV15-2,MAD homolog 3,MAD, mothers against decapentaplegic homolog 3,MADH3,MGC60396,Mad3,Mothers against DPP homolog 3,Mothers against decapentaplegic homolog 3,SMA- and MAD-related protein 3,SMAD 3,SMAD family member 3,SMAD, mothers against DPP homolog 3,SMAD3,hMAD-3,hSMAD3,mad homolog JV15-2,mad protein homolog
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。