产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
磷酸酶张力蛋白同源基因(138G6)兔单克隆抗体
目录 :
9559
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
138G6
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, mass cytometry, 免疫印迹基因敲除验证, 免疫组化基因敲除验证
文章摘录数: 197
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 3c
Lin G, Li J, Cai J, Zhang H, Xin Q, Wang N, et al. RNA-binding Protein MBNL2 regulates Cancer Cell Metastasis through MiR-182-MBNL2-AKT Pathway. J Cancer. 2021;12:6715-6726 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s8a
Correia de Sousa M, Calo N, Sobolewski C, Gjorgjieva M, Clement S, Maeder C, et al. Mir-21 Suppression Promotes Mouse Hepatocarcinogenesis. Cancers (Basel). 2021;13: pubmed 出版商
  • 免疫印迹; 人类; 图 2g
Ali A, Kuo W, Kuo C, Lo J, Chen M, Daddam J, et al. E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages. Bioeng Transl Med. 2021;6:e10234 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 1g
  • 免疫印迹; 小鼠; 1:1000; 图 3b
Langdon C, Gadek K, Garcia M, Evans M, Reed K, Bush M, et al. Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. Nat Commun. 2021;12:5520 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 3e
Pham Q, Taniyama D, Sekino Y, Akabane S, Babasaki T, Kobayashi G, et al. Clinicopathologic features of TDO2 overexpression in renal cell carcinoma. BMC Cancer. 2021;21:737 pubmed 出版商
  • 免疫印迹; 人类; 图 5d
  • 免疫组化; 小鼠; 图 5a
  • 免疫印迹; 小鼠; 图 5d
Hamm M, Sohier P, Petit V, Raymond J, Delmas V, Le Coz M, et al. BRN2 is a non-canonical melanoma tumor-suppressor. Nat Commun. 2021;12:3707 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3f
Diaz González M, Buberman A, Morales M, Ferrer I, Knafo S. Aberrant Synaptic PTEN in Symptomatic Alzheimer's Patients May Link Synaptic Depression to Network Failure. Front Synaptic Neurosci. 2021;13:683290 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 4
Hewa Bostanthirige D, Komaragiri S, Joshi J, Alzahrani M, Saini I, Jain S, et al. The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate. Oncoscience. 2021;8:14-30 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Wang H, Radomska H, Phelps M, Iorns E, Tsui R, Denis A, et al. Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Tan Y, Sementino E, Liu Z, Cai K, Testa J. Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis. Sci Rep. 2020;10:15837 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 2d, 2h
  • 免疫印迹; 人类; 图 2s2b
Brunner A, Suryo Rahmanto A, Johansson H, Franco M, Viiliäinen J, Gazi M, et al. PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3b
Kerwin J, Khan I, Iorns E, Tsui R, Denis A, Perfito N, et al. Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s1d
Hermanova I, Z iga Garc a P, Caro Maldonado A, Fernandez Ruiz S, Salvador F, Mart n Mart n N, et al. Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer. J Exp Med. 2020;217: pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 4
Gugel I, Ebner F, Grimm F, Czemmel S, Paulsen F, Hagel C, et al. Contribution of mTOR and PTEN to Radioresistance in Sporadic and NF2-Associated Vestibular Schwannomas: A Microarray and Pathway Analysis. Cancers (Basel). 2020;12: pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 1c
Che L, Chi W, Qiao Y, Zhang J, Song X, Liu Y, et al. Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. Gut. 2020;69:177-186 pubmed 出版商
  • 免疫印迹; 人类; 1:500-1:2000; 图 s2e
Wall C, Rose C, Adrian M, Zeng Y, Kirkpatrick D, Bingol B. PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin. Cell Rep. 2019;29:3280-3292.e7 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6c, 6f, s15b
Ghezzi C, Wong A, Chen B, Ribalet B, Damoiseaux R, Clark P. A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. Nat Commun. 2019;10:5444 pubmed 出版商
  • 免疫印迹; 大鼠; 图 1a
Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, et al. The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches. Cell Rep. 2019;29:2028-2040.e8 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 2b
Mao N, Gao D, Hu W, Hieronymus H, Wang S, Lee Y, et al. Aberrant Expression of ERG Promotes Resistance to Combined PI3K and AR Pathway Inhibition through Maintenance of AR Target Genes. Mol Cancer Ther. 2019;18:1577-1586 pubmed 出版商
  • 免疫印迹; 人类; 图 4m
Lu Q, Liu T, Feng H, Yang R, Zhao X, Chen W, et al. Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN. Mol Cancer. 2019;18:111 pubmed 出版商
  • 免疫沉淀; 人类; 1:500; 图 s2g
  • 免疫印迹; 人类; 图 s2g
Lee Y, Chen M, Lee J, Zhang J, Lin S, Fu T, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019;364: pubmed 出版商
  • mass cytometry; 人类; 图 3a
Wagner J, Rapsomaniki M, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, et al. A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer. Cell. 2019;177:1330-1345.e18 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5d
Zhu M, Lu T, Jia Y, Luo X, Gopal P, Li L, et al. Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease. Cell. 2019;177:608-621.e12 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4a
Ding Y, Li N, Dong B, Guo W, Wei H, Chen Q, et al. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. J Clin Invest. 2019;129:759-773 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Kim C, Hu B, Jadhav R, Jin J, Zhang H, Cavanagh M, et al. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Cell Rep. 2018;25:2148-2162.e5 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 5a
Anker J, Naseem A, Mok H, Schaeffer A, Abdulkadir S, Thumbikat P. Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy. Nat Commun. 2018;9:1591 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Vu L, Pickering B, Cheng Y, Zaccara S, Nguyen D, Minuesa G, et al. The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017;23:1369-1376 pubmed 出版商
  • 免疫印迹; 人类; 图 4b
  • 免疫印迹; 小鼠; 图 4a, 4b
Comiskey D, Jacob A, Sanford B, Montes M, Goodwin A, Steiner H, et al. A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo. Oncogene. 2018;37:95-106 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3c
Simond A, Rao T, Zuo D, Zhao J, Muller W. ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor. Oncogene. 2017;36:6059-6066 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 2a
  • 免疫组化; 人类; 图 s6k
Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017;546:554-558 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3a
Ahmed S, Macara I. The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. Nat Commun. 2017;8:14867 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Gupta A, Anjomani Virmouni S, Koundouros N, Dimitriadi M, Choo Wing R, Valle A, et al. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell. 2017;65:999-1013.e7 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 4d
Cen M, Hu P, Cai Z, Fang T, Zhang J, Lu M. TIEG1 deficiency confers enhanced myocardial protection in the infarcted heart by mediating the Pten/Akt signalling pathway. Int J Mol Med. 2017;39:569-578 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:500; 图 2c
Callif B, Maunze B, Krueger N, Simpson M, Blackmore M. The application of CRISPR technology to high content screening in primary neurons. Mol Cell Neurosci. 2017;80:170-179 pubmed 出版商
  • 免疫印迹; 人类; 图 1d
Wilkerson P, Dedes K, Samartzis E, Dedes I, Lambros M, Natrajan R, et al. Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer. Oncotarget. 2017;8:6057-6066 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1
Fourneaux B, Chaire V, Lucchesi C, Karanian M, Pineau R, Laroche Clary A, et al. Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications. Oncotarget. 2017;8:7878-7890 pubmed 出版商
  • 免疫印迹; 人类; 图 7A
Vuono E, Mukherjee A, Vierra D, Adroved M, Hodson C, Deans A, et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016;6:36439 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1e
Sheen M, Marotti J, Allegrezza M, Rutkowski M, Conejo Garcia J, Fiering S. Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer. Oncogenesis. 2016;5:e267 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3a
Hau A, Leivo M, Gilder A, Hu J, Gonias S, Hansel D. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer. Cell Signal. 2017;29:96-106 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 1
  • 免疫印迹; 小鼠; 图 1
Yuzugullu H, Von T, Thorpe L, Walker S, Roberts T, Frank D, et al. NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways. Cell Discov. 2016;2:16030 pubmed 出版商
  • 免疫组化基因敲除验证; 大鼠; 1:50; 图 1
Chen P, Qin L, Li G, Tellides G, Simons M. Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGF?)-dependent smooth muscle cell phenotype modulation. Sci Rep. 2016;6:33407 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 5
Bourgonje A, Verrijp K, Schepens J, Navis A, Piepers J, Palmen C, et al. Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma. Acta Neuropathol Commun. 2016;4:96 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 5a
Chen R, Duan J, Li L, Ma Q, Sun Q, Ma J, et al. mTOR promotes pituitary tumor development through activation of PTTG1. Oncogene. 2017;36:979-988 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Lai M, Gonzalez Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed 出版商
  • 免疫组化; 人类; 图 1a
Hatem R, El Botty R, Chateau Joubert S, Servely J, Labiod D, de Plater L, et al. Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers. Oncotarget. 2016;7:48206-48219 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Tzani I, Ivanov I, Andreev D, Dmitriev R, Dean K, Baranov P, et al. Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoform. Open Biol. 2016;6: pubmed 出版商
  • 免疫沉淀; 小鼠; 图 2
  • 免疫印迹; 小鼠; 图 1
  • 免疫印迹; 人类; 图 s3
van Ree J, Nam H, Jeganathan K, Kanakkanthara A, van Deursen J. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nat Cell Biol. 2016;18:814-21 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s1
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 表 1
  • 免疫印迹; 人类; 图 1
Castillo Martin M, Thin T, Collazo Lorduy A, Cordon Cardo C. Immunopathologic Assessment of PTEN Expression. Methods Mol Biol. 2016;1388:23-37 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Lynch J, McEwen R, Crafter C, McDermott U, Garnett M, Barry S, et al. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. Oncotarget. 2016;7:22128-39 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7
Joo M, Park J, Yoo H, Lee B, Chun H, Lee S, et al. The roles of HOXB7 in promoting migration, invasion, and anti-apoptosis in gastric cancer. J Gastroenterol Hepatol. 2016;31:1717-1726 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 s1
Koussounadis A, Langdon S, Um I, Kay C, Francis K, Harrison D, et al. Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models. BMC Cancer. 2016;16:205 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Jin H, Gonzalez Martin A, Miletic A, Lai M, Knight S, Sabouri Ghomi M, et al. Transfection of microRNA Mimics Should Be Used with Caution. Front Genet. 2015;6:340 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 1
Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, et al. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015;6:10068 pubmed 出版商
  • 免疫组化基因敲除验证; 大鼠; 1:50; 图 1
Chen F, Rosiene J, Che A, Becker A, LoTurco J. Tracking and transforming neocortical progenitors by CRISPR/Cas9 gene targeting and piggyBac transposase lineage labeling. Development. 2015;142:3601-11 pubmed 出版商
  • 免疫沉淀; 人类; 1:50; 图 2c
Conde Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, et al. A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nat Commun. 2015;6:8093 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1c
Lee M, Jeong M, Lee H, Han H, Ko A, Hewitt S, et al. PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis. Nat Commun. 2015;6:7769 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 1
Lokody I, Francis J, Gardiner J, Erler J, Swain A. Pten Regulates Epithelial Cytodifferentiation during Prostate Development. PLoS ONE. 2015;10:e0129470 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Dorr C, Janik C, Weg M, Been R, Bader J, Kang R, et al. Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. Mol Cancer Res. 2015;13:1238-47 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 1
Ruscetti M, Quach B, Dadashian E, Mulholland D, Wu H. Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis. Cancer Res. 2015;75:2749-59 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Liu H, Du L, Wang R, Wei C, Liu B, Zhu L, et al. High frequency of loss of PTEN expression in human solid salivary adenoid cystic carcinoma and its implication for targeted therapy. Oncotarget. 2015;6:11477-91 pubmed
  • 免疫印迹; 小鼠; 1:1000; 图 5
Apostoli A, Roche J, Schneider M, SenGupta S, Di Lena M, Rubino R, et al. Opposing roles for mammary epithelial-specific PPARγ signaling and activation during breast tumour progression. Mol Cancer. 2015;14:85 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s1
Chen S, Sanjana N, Zheng K, Shalem O, Lee K, Shi X, et al. Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell. 2015;160:1246-60 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 2
  • 免疫印迹; 人类; 图 2
Ho J, Bassi C, Stambolic V. Characterization of nuclear PTEN and its post translational modifications. Methods. 2015;77-78:104-11 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s7
Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol. 2015;16:178-87 pubmed 出版商
  • 免疫组化; 人类; 表 2
Eritja N, Santacana M, Maiques O, González Tallada X, Dolcet X, Matias Guiu X. Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model. Methods. 2015;77-78:31-40 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
  • 免疫印迹; 人类; 图 1
Choi M, Nakamura T, Cho S, Han X, Holland E, Qu J, et al. Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. J Neurosci. 2014;34:15123-31 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类; 1:200; 图 2
  • 免疫印迹; 人类; 图 2
Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 9b
Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, et al. Nrf2 enhances cholangiocyte expansion in Pten-deficient livers. Mol Cell Biol. 2014;34:900-13 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Apostoli A, Skelhorne Gross G, Rubino R, Peterson N, Di Lena M, Schneider M, et al. Loss of PPAR? expression in mammary secretory epithelial cells creates a pro-breast tumorigenic environment. Int J Cancer. 2014;134:1055-66 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Burkhardt L, Fuchs S, Krohn A, Masser S, Mader M, Kluth M, et al. CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer. Cancer Res. 2013;73:2795-805 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Sha W, Thompson K, South J, Baron M, Leask A. Loss of PPAR? expression by fibroblasts enhances dermal wound closure. Fibrogenesis Tissue Repair. 2012;5:5 pubmed 出版商
  • 免疫组化基因敲除验证; 小鼠; 图 3
Rodriguez O, Lai E, Vissapragada S, Cromelin C, Avetian M, Salinas P, et al. A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1. Am J Pathol. 2009;174:2051-60 pubmed 出版商
Friesen L, Gu B, Kim C. A ligand-independent fast function of RARα promotes exit from metabolic quiescence upon T cell activation and controls T cell differentiation. Mucosal Immunol. 2020;: pubmed 出版商
Katsuyama T, Li H, Comte D, Tsokos G, Moulton V. Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity. J Clin Invest. 2019;129:5411-5423 pubmed 出版商
Perez E, de Haas S, Eiermann W, Barrios C, Toi M, Im Y, et al. Relationship between tumor biomarkers and efficacy in MARIANNE, a phase III study of trastuzumab emtansine ± pertuzumab versus trastuzumab plus taxane in HER2-positive advanced breast cancer. BMC Cancer. 2019;19:517 pubmed 出版商
Islam M, Xu Y, Tao W, Ubellacker J, Lim M, Aum D, et al. Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. Nat Biomed Eng. 2018;2:850-864 pubmed 出版商
Gao Z, Zhang P, Xie M, Gao H, Yin L, Liu R. miR-144/451 cluster plays an oncogenic role in esophageal cancer by inhibiting cell invasion. Cancer Cell Int. 2018;18:184 pubmed 出版商
Saintigny P, Mitani Y, Pytynia K, Ferrarotto R, Roberts D, Weber R, et al. Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. Cancer. 2018;124:3693-3705 pubmed 出版商
Schoffski P, Cresta S, Mayer I, Wildiers H, Damian S, Gendreau S, et al. A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer. Breast Cancer Res. 2018;20:109 pubmed 出版商
Wang L, Cho Y, Tang Y, Wang J, Park J, Wu Y, et al. PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell Res. 2018;28:787-802 pubmed 出版商
Oldrini B, Curiel García A, Marques C, Matia V, Uluçkan O, Graña Castro O, et al. Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling. Nat Commun. 2018;9:1466 pubmed 出版商
Pishvaian M, Slack R, Jiang W, He A, Hwang J, Hankin A, et al. A phase 2 study of the PARP inhibitor veliparib plus temozolomide in patients with heavily pretreated metastatic colorectal cancer. Cancer. 2018;124:2337-2346 pubmed 出版商
Pezo R, Chen T, Berman H, Mulligan A, Razak A, Siu L, et al. Impact of multi-gene mutational profiling on clinical trial outcomes in metastatic breast cancer. Breast Cancer Res Treat. 2018;168:159-168 pubmed 出版商
Cyll K, Ersvær E, Vlatkovic L, Pradhan M, Kildal W, Avranden Kjær M, et al. Tumour heterogeneity poses a significant challenge to cancer biomarker research. Br J Cancer. 2017;117:367-375 pubmed 出版商
Kim S, Lee J, Park S, Park J, Park Y, Kang W, et al. Prospective phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy. BMC Cancer. 2017;17:211 pubmed 出版商
Yu E, Hooker E, Johnson D, Kwak M, Zou K, Luong R, et al. LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis. PLoS ONE. 2017;12:e0174357 pubmed 出版商
Yang J, Schiapparelli P, Nguyen H, Igarashi A, Zhang Q, Abbadi S, et al. Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization. Oncogene. 2017;36:3673-3685 pubmed 出版商
Pomeroy E, Lee L, Lee R, Schirm D, Temiz N, Ma J, et al. Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. Oncogene. 2017;36:3263-3273 pubmed 出版商
Yeom C, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, et al. LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis. Oncotarget. 2016;7:65837-65848 pubmed 出版商
Xiong S, Cheng J, Klausen C, Zhao J, Leung P. TGF-β1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways. Oncotarget. 2016;7:61262-61272 pubmed 出版商
Mukai H, Saeki T, Aogi K, Naito Y, Matsubara N, Shigekawa T, et al. Patritumab plus trastuzumab and paclitaxel in human epidermal growth factor receptor 2-overexpressing metastatic breast cancer. Cancer Sci. 2016;107:1465-1470 pubmed 出版商
Ágoston E, Micsik T, Acs B, Fekete K, Hahn O, Baranyai Z, et al. In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity. Diagn Pathol. 2016;11:61 pubmed 出版商
Kabir T, Leigh R, Tasena H, Mellone M, Coletta R, Parkinson E, et al. A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts. Aging (Albany NY). 2016;8:1608-35 pubmed 出版商
Ahmad I, Mui E, Galbraith L, Patel R, Tan E, Salji M, et al. Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proc Natl Acad Sci U S A. 2016;113:8290-5 pubmed 出版商
Manchado E, Weissmueller S, Morris J, Chen C, Wullenkord R, Lujambio A, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016;534:647-51 pubmed
Amir S, Simion C, Umeh Garcia M, Krig S, Moss T, Carraway K, et al. Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer. Br J Cancer. 2016;114:1125-34 pubmed 出版商
Ma M, He M, Jiang Q, Yan Y, Guan S, Zhang J, et al. MiR-487a Promotes TGF-?1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2. Int J Biol Sci. 2016;12:397-408 pubmed 出版商
Zhang X, Guo W, Wang X, Liu X, Huang M, Gan L, et al. Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer. Oncotarget. 2016;7:22733-45 pubmed 出版商
Phelps M, Coss C, Wang H, Cook M. Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. elife. 2016;5: pubmed 出版商
Zhou Y, Yang Q, Xu H, Zhang J, Deng H, Gao H, et al. miRNA-221-3p Enhances the Secretion of Interleukin-4 in Mast Cells through the Phosphatase and Tensin Homolog/p38/Nuclear Factor-kappaB Pathway. PLoS ONE. 2016;11:e0148821 pubmed 出版商
Grego Bessa J, Bloomekatz J, Castel P, Omelchenko T, Baselga J, Anderson K. The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. elife. 2016;5:e12034 pubmed 出版商
Zhang H, Yan X. Cantharidin modulates the E2F1/MCM7-miR-106b-93/p21-PTEN signaling axis in MCF-7 breast cancer cells. Oncol Lett. 2015;10:2849-2855 pubmed
Katsura Y, Kubota H, Kunida K, Kanno A, Kuroda S, Ozawa T. An optogenetic system for interrogating the temporal dynamics of Akt. Sci Rep. 2015;5:14589 pubmed 出版商
Shen S, Guo M, Xiong Z, Yu Y, Zhao X, Zhang F, et al. AIF inhibits tumor metastasis by protecting PTEN from oxidation. EMBO Rep. 2015;16:1563-80 pubmed 出版商
Lu J, Pan Y, Xia X, Gu Y, Lei Y. Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. Biomed Res Int. 2015;2015:417210 pubmed 出版商
Cowley D, Pandya K, Khan I, Kerwin J, Owen K, Griner E. Registered report: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. elife. 2015;4: pubmed 出版商
Stamatkin C, Ratermann K, Overley C, Black E. Inhibition of class IA PI3K enzymes in non-small cell lung cancer cells uncovers functional compensation among isoforms. Cancer Biol Ther. 2015;16:1341-52 pubmed 出版商
Wang D, Mou H, Li S, Li Y, Hough S, Tran K, et al. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Hum Gene Ther. 2015;26:432-42 pubmed 出版商
Liu Z, Ren Y, Pangas S, Adams J, Zhou W, Castrillon D, et al. FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. Mol Endocrinol. 2015;29:1006-24 pubmed 出版商
Hawse W, Sheehan R, Miskov Zivanov N, Menk A, Kane L, Faeder J, et al. Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+ T Cell Fate Decisions. J Immunol. 2015;194:4615-9 pubmed 出版商
Ugalde Olano A, Egia A, Fernández Ruiz S, Loizaga Iriarte A, Zuñiga García P, Garcia S, et al. Methodological aspects of the molecular and histological study of prostate cancer: focus on PTEN. Methods. 2015;77-78:25-30 pubmed 出版商
Niemeyer B, Parrish J, Spoelstra N, Joyal T, Richer J, Jedlicka P. Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes. PLoS ONE. 2015;10:e0116895 pubmed 出版商
Kuhla A, Thrum M, Schaeper U, Fehring V, Schulze Topphoff U, Abshagen K, et al. Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury. Apoptosis. 2015;20:500-11 pubmed 出版商
Munkley J, Lafferty N, Kalna G, Robson C, Leung H, Rajan P, et al. Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells. BMC Cancer. 2015;15:9 pubmed 出版商
Ferraldeschi R, Nava Rodrigues D, Riisnaes R, Miranda S, Figueiredo I, Rescigno P, et al. PTEN protein loss and clinical outcome from castration-resistant prostate cancer treated with abiraterone acetate. Eur Urol. 2015;67:795-802 pubmed 出版商
Juric D, Castel P, Griffith M, Griffith O, Won H, Ellis H, et al. Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor. Nature. 2015;518:240-4 pubmed 出版商
Rubattu S, Marchitti S, Bianchi F, Di Castro S, Stanzione R, Cotugno M, et al. The C2238/αANP variant is a negative modulator of both viability and function of coronary artery smooth muscle cells. PLoS ONE. 2014;9:e113108 pubmed 出版商
Sanchez Rivera F, Papagiannakopoulos T, Romero R, Tammela T, Bauer M, Bhutkar A, et al. Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Nature. 2014;516:428-31 pubmed 出版商
Fu X, Creighton C, Biswal N, Kumar V, Shea M, Herrera S, et al. Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. Breast Cancer Res. 2014;16:430 pubmed 出版商
Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi N, et al. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 2014;514:380-4 pubmed 出版商
Yahiaoui O, Nunes J, Castanier C, Devillier R, Broussais F, Fabre A, et al. Constitutive AKT activation in follicular lymphoma. BMC Cancer. 2014;14:565 pubmed 出版商
Vignarajan S, Xie C, Yao M, Sun Y, Simanainen U, Sved P, et al. Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A?? via AKT in prostate cancer cells. Oncotarget. 2014;5:6289-99 pubmed 出版商
Patel M, Gomez N, McFadden A, Moats Staats B, Wu S, Rojas A, et al. PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition. Mol Cancer Res. 2014;12:1610-20 pubmed 出版商
Chiang E, Tsai S, Kuo Y, Pai M, Chiu H, Rodriguez R, et al. Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways. PLoS ONE. 2014;9:e99631 pubmed 出版商
Miething C, Scuoppo C, Bosbach B, Appelmann I, Nakitandwe J, Ma J, et al. PTEN action in leukaemia dictated by the tissue microenvironment. Nature. 2014;510:402-6 pubmed 出版商
Andre F, O Regan R, Ozguroglu M, Toi M, Xu B, Jerusalem G, et al. Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncol. 2014;15:580-91 pubmed 出版商
Miller K, Dieras V, Harbeck N, Andre F, Mahtani R, Gianni L, et al. Phase IIa trial of trastuzumab emtansine with pertuzumab for patients with human epidermal growth factor receptor 2-positive, locally advanced, or metastatic breast cancer. J Clin Oncol. 2014;32:1437-44 pubmed 出版商
Nho R, Hergert P. IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases. PLoS ONE. 2014;9:e94616 pubmed 出版商
Höland K, Boller D, Hagel C, Dolski S, Treszl A, Pardo O, et al. Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. PLoS ONE. 2014;9:e94132 pubmed 出版商
Heller B, Ghidinelli M, Voelkl J, Einheber S, Smith R, Grund E, et al. Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. J Cell Biol. 2014;204:1219-36 pubmed 出版商
Miyasaka A, Oda K, Ikeda Y, Wada Hiraike O, Kashiyama T, Enomoto A, et al. Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells. BMC Cancer. 2014;14:179 pubmed 出版商
Bourgon R, Lu S, Yan Y, Lackner M, Wang W, Weigman V, et al. High-throughput detection of clinically relevant mutations in archived tumor samples by multiplexed PCR and next-generation sequencing. Clin Cancer Res. 2014;20:2080-91 pubmed 出版商
Chen C, Lei W, Chen W, Zhong J, Gao X, Li B, et al. Serum TGF-?1 and SMAD3 levels are closely associated with coronary artery disease. BMC Cardiovasc Disord. 2014;14:18 pubmed 出版商
Wang L, Hu H, Pan Y, Wang R, Li Y, Shen L, et al. PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cell lung cancer and suggest poor prognosis in EGFR/KRAS wildtype subgroup. PLoS ONE. 2014;9:e88291 pubmed 出版商
Stjernström A, Karlsson C, Fernandez O, Söderkvist P, Karlsson M, Thunell L. Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung. Cancer Med. 2014;3:337-48 pubmed 出版商
Wong C, Martincorena I, Rust A, Rashid M, Alifrangis C, Alexandrov L, et al. Inactivating CUX1 mutations promote tumorigenesis. Nat Genet. 2014;46:33-8 pubmed 出版商
Cumberbatch M, Tang X, Beran G, Eckersley S, Wang X, Ellston R, et al. Identification of a subset of human non-small cell lung cancer patients with high PI3K? and low PTEN expression, more prevalent in squamous cell carcinoma. Clin Cancer Res. 2014;20:595-603 pubmed 出版商
Karapetis C, Jonker D, Daneshmand M, Hanson J, O Callaghan C, Marginean C, et al. PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17. Clin Cancer Res. 2014;20:744-53 pubmed 出版商
Atreya C, Sangale Z, Xu N, Matli M, Tikishvili E, Welbourn W, et al. PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. Cancer Med. 2013;2:496-506 pubmed 出版商
Garcia Carracedo D, Turk A, Fine S, Akhavan N, Tweel B, Parsons R, et al. Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas. Clin Cancer Res. 2013;19:6830-41 pubmed 出版商
Falkenberg N, Anastasov N, Rappl K, Braselmann H, Auer G, Walch A, et al. MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion. Br J Cancer. 2013;109:2714-23 pubmed 出版商
Beckham T, Cheng J, Lu P, Marrison S, Norris J, Liu X. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS ONE. 2013;8:e76593 pubmed 出版商
Yoshikawa T, Otsuka M, Kishikawa T, Takata A, Ohno M, Shibata C, et al. Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model. PLoS ONE. 2013;8:e71969 pubmed 出版商
Yip W, Choo C, Leong V, Leong P, Jabar M, Seow H. Molecular alterations of Ras-Raf-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt signaling pathways in colorectal cancers from a tertiary hospital at Kuala Lumpur, Malaysia. APMIS. 2013;121:954-66 pubmed 出版商
Hsu H, Cheng L, Ho T, Kuo W, Lin Y, Chen M, et al. Apicidin-resistant HA22T hepatocellular carcinoma cells massively promote pro-survival capability via IGF-IR/PI3K/Akt signaling pathway activation. Tumour Biol. 2014;35:303-13 pubmed 出版商
Locke F, Zha Y, Zheng Y, Driessens G, Gajewski T. Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction. J Immunol. 2013;191:1677-85 pubmed 出版商
Aftimos P, Wiedig M, Langouo Fontsa M, Awada A, Ghanem G, Journe F. Sequential use of protein kinase inhibitors potentiates their toxicity to melanoma cells: a rationale to combine targeted drugs based on protein expression inhibition profiles. Int J Oncol. 2013;43:919-26 pubmed 出版商
Chang K, Tsai S, Chen S, Tsou H, Yen C, Liu K, et al. Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance. J Biomed Sci. 2013;20:43 pubmed 出版商
Waniczek D, Snietura M, Pigłowski W, Rdes J, Kopec A, Młynarczyk Liszka J, et al. Analysis of PTEN expression in large intestine polyps and its relation to the recognized histopathological and clinical risk factors for cancer development in this location. Contemp Oncol (Pozn). 2012;16:310-5 pubmed 出版商
Sharma P, Knowell A, Chinaranagari S, Komaragiri S, Nagappan P, Patel D, et al. Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol Cancer. 2013;12:67 pubmed 出版商
Beckham T, Cheng J, Lu P, Shao Y, Troyer D, Lance R, et al. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis. 2013;2:e49 pubmed 出版商
Yin L, Cai W, Liu C, Chen Y, Hu J, Jiang J, et al. Analysis of PTEN methylation patterns in soft tissue sarcomas by MassARRAY spectrometry. PLoS ONE. 2013;8:e62971 pubmed 出版商
Burgers T, Hoffmann M, Collins C, Zahatnansky J, Alvarado M, Morris M, et al. Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing. PLoS ONE. 2013;8:e63857 pubmed 出版商
Tinker A, Ellard S, Welch S, Moens F, Allo G, Tsao M, et al. Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199). Gynecol Oncol. 2013;130:269-74 pubmed 出版商
Singh M, Chaudhry P, Fabi F, Asselin E. Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance. BMC Cancer. 2013;13:233 pubmed 出版商
Waniczek D, Snietura M, Młynarczyk Liszka J, Pigłowski W, Kopec A, Lange D, et al. PTEN expression profiles in colorectal adenocarcinoma and its precancerous lesions. Pol J Pathol. 2013;64:15-20 pubmed
Sarfstein R, Friedman Y, Attias Geva Z, Fishman A, Bruchim I, Werner H. Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners. PLoS ONE. 2013;8:e61537 pubmed 出版商
Sampurno S, Bijenhof A, Cheasley D, Xu H, Robine S, Hilton D, et al. The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis. Cell Death Dis. 2013;4:e605 pubmed 出版商
Ludyga N, Englert S, Pflieger K, Rauser S, Braselmann H, Walch A, et al. The impact of cysteine-rich intestinal protein 1 (CRIP1) in human breast cancer. Mol Cancer. 2013;12:28 pubmed 出版商
Dufour J, Pommier A, Alves G, de Boussac H, Lours Calet C, Volle D, et al. Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell. PLoS ONE. 2013;8:e58876 pubmed 出版商
Muppala S, Mudduluru G, Leupold J, Buergy D, Sleeman J, Allgayer H. CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a. PLoS ONE. 2013;8:e59563 pubmed 出版商
Wu R, Baker S, Hu T, Norman K, Fearon E, Cho K. Type I to type II ovarian carcinoma progression: mutant Trp53 or Pik3ca confers a more aggressive tumor phenotype in a mouse model of ovarian cancer. Am J Pathol. 2013;182:1391-9 pubmed 出版商
Zhu X, Qin X, Fei M, Hou W, Greshock J, Bachman K, et al. Loss and reduced expression of PTEN correlate with advanced-stage gastric carcinoma. Exp Ther Med. 2013;5:57-64 pubmed
Bettstetter M, Berezowska S, Keller G, Walch A, Feuchtinger A, Slotta Huspenina J, et al. Epidermal growth factor receptor, phosphatidylinositol-3-kinase catalytic subunit/PTEN, and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas: loss of PTEN is associated with worse clinical outcome. Hum Pathol. 2013;44:829-36 pubmed 出版商
Rodriguez S, Huynh Do U. Phosphatase and tensin homolog regulates stability and activity of EphB1 receptor. FASEB J. 2013;27:632-44 pubmed 出版商
Helmy K, Halliday J, Fomchenko E, Setty M, Pitter K, Hafemeister C, et al. Identification of global alteration of translational regulation in glioma in vivo. PLoS ONE. 2012;7:e46965 pubmed 出版商
Kayali S, Giraud G, Morle F, Guyot B. Spi-1, Fli-1 and Fli-3 (miR-17-92) oncogenes contribute to a single oncogenic network controlling cell proliferation in friend erythroleukemia. PLoS ONE. 2012;7:e46799 pubmed 出版商
Teng Y, Manavalan T, Hu C, Medjakovic S, Jungbauer A, Klinge C. Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells. Toxicol Sci. 2013;131:71-83 pubmed 出版商
Yanagawa N, Leduc C, Kohler D, Saieg M, John T, Sykes J, et al. Loss of phosphatase and tensin homolog protein expression is an independent poor prognostic marker in lung adenocarcinoma. J Thorac Oncol. 2012;7:1513-21 pubmed
Zhu X, Qin X, Fei M, Hou W, Greshock J, Bachman K, et al. Combined phosphatase and tensin homolog (PTEN) loss and fatty acid synthase (FAS) overexpression worsens the prognosis of Chinese patients with hepatocellular carcinoma. Int J Mol Sci. 2012;13:9980-91 pubmed 出版商
Iqbal J, Thike A, Cheok P, Tse G, Tan P. Insulin growth factor receptor-1 expression and loss of PTEN protein predict early recurrence in triple-negative breast cancer. Histopathology. 2012;61:652-9 pubmed 出版商
Lv S, Teugels E, Sadones J, De Brakeleer S, Duerinck J, DU Four S, et al. Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab. Int J Oncol. 2012;41:1029-35 pubmed 出版商
Barbareschi M, Cuorvo L, Girlando S, Bragantini E, Eccher C, Leonardi E, et al. PI3KCA mutations and/or PTEN loss in Her2-positive breast carcinomas treated with trastuzumab are not related to resistance to anti-Her2 therapy. Virchows Arch. 2012;461:129-39 pubmed 出版商
Snietura M, Jaworska M, Mlynarczyk Liszka J, Goraj Zając A, Piglowski W, Lange D, et al. PTEN as a prognostic and predictive marker in postoperative radiotherapy for squamous cell cancer of the head and neck. PLoS ONE. 2012;7:e33396 pubmed 出版商
Cantrup R, Dixit R, Palmesino E, Bonfield S, Shaker T, Tachibana N, et al. Cell-type specific roles for PTEN in establishing a functional retinal architecture. PLoS ONE. 2012;7:e32795 pubmed 出版商
Scrima M, De Marco C, Fabiani F, Franco R, Pirozzi G, Rocco G, et al. Signaling networks associated with AKT activation in non-small cell lung cancer (NSCLC): new insights on the role of phosphatydil-inositol-3 kinase. PLoS ONE. 2012;7:e30427 pubmed 出版商
Lerch J, Kuo F, Motti D, Morris R, Bixby J, Lemmon V. Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq. PLoS ONE. 2012;7:e30417 pubmed 出版商
Heindl M, Händel N, Ngeow J, Kionke J, Wittekind C, Kamprad M, et al. Autoimmunity, intestinal lymphoid hyperplasia, and defects in mucosal B-cell homeostasis in patients with PTEN hamartoma tumor syndrome. Gastroenterology. 2012;142:1093-1096.e6 pubmed 出版商
Ettl T, Baader K, Stiegler C, Muller M, Agaimy A, Zenk J, et al. Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. Br J Cancer. 2012;106:719-26 pubmed 出版商
Valkov A, Kilvaer T, Sorbye S, Donnem T, Smeland E, Bremnes R, et al. The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas. J Transl Med. 2011;9:200 pubmed 出版商
Kye M, Neveu P, Lee Y, Zhou M, Steen J, Sahin M, et al. NMDA mediated contextual conditioning changes miRNA expression. PLoS ONE. 2011;6:e24682 pubmed 出版商
Lee D, Do I, Choi K, Sung C, Jang K, Choi D, et al. The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. Mod Pathol. 2012;25:131-9 pubmed 出版商
Ahmad I, Patel R, Liu Y, Singh L, Taketo M, Wu X, et al. Ras mutation cooperates with ?-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2011;2:e124 pubmed 出版商
Pitter K, Galban C, Galban S, Tehrani O, Saeed Tehrani O, Li F, et al. Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma. PLoS ONE. 2011;6:e14545 pubmed 出版商
Sangale Z, Prass C, Carlson A, Tikishvili E, Degrado J, Lanchbury J, et al. A robust immunohistochemical assay for detecting PTEN expression in human tumors. Appl Immunohistochem Mol Morphol. 2011;19:173-83 pubmed 出版商
Van Themsche C, Chaudhry P, Leblanc V, Parent S, Asselin E. XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. Mol Cancer. 2010;9:216 pubmed 出版商
Javle M, Shroff R, Xiong H, Varadhachary G, Fogelman D, Reddy S, et al. Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies. BMC Cancer. 2010;10:368 pubmed 出版商
Castellino R, Barwick B, Schniederjan M, Buss M, Becher O, Hambardzumyan D, et al. Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma. PLoS ONE. 2010;5:e10849 pubmed 出版商
Kim T, Franco H, Jung S, Qin J, Broaddus R, Lydon J, et al. The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. Oncogene. 2010;29:3770-80 pubmed 出版商
Toi M, Iwata H, Fujiwara Y, Ito Y, Nakamura S, Tokuda Y, et al. Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studies. Br J Cancer. 2009;101:1676-82 pubmed 出版商
McBride S, Perez D, Polley M, VandenBerg S, Smith J, Zheng S, et al. Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival. J Neurooncol. 2010;97:33-40 pubmed 出版商
Guertin D, Stevens D, Saitoh M, Kinkel S, Crosby K, Sheen J, et al. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell. 2009;15:148-59 pubmed 出版商
Zheng H, Ying H, Yan H, Kimmelman A, Hiller D, Chen A, et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008;455:1129-33 pubmed 出版商
Laguë M, Paquet M, Fan H, Kaartinen M, Chu S, Jamin S, et al. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis. 2008;29:2062-72 pubmed 出版商
Saal L, Gruvberger Saal S, Persson C, Lövgren K, Jumppanen M, Staaf J, et al. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet. 2008;40:102-7 pubmed
产品信息
SKU号 :
9559L
产品名称 :
磷酸酶张力蛋白同源基因(138G6)兔单克隆抗体
规格 :
300微升
Price-(USD) :
574美元
物种x :
H, M, R, Mk
应用 :
免疫组化(石蜡)
产品种类 :
PI3K / Akt Signaling
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
54
宿主 :
靶标 :
磷酸酶张力蛋白同源基因
最初蛋白 :
磷酸酶张力蛋白同源基因
别名 :
10q23del,BZS,DEC,MGC11227,MHAM,MMAC1,MMAC1 phosphatase and tensin homolog deleted on chromosome 10,Mutated in multiple advanced cancers 1,PTEN,PTEN1,Phosphatase and tensin homolog,Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN,TEP1
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。