产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
切断的胱氨酸-天冬氨酸蛋白酶3(Asp175)(5A1E)兔单克隆抗体
目录 :
9664
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
5A1E
反应物种 :
African green monkey, 人类, 小鼠, 大鼠, , , 斑马鱼, 猕猴, purple urchin
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片, 其他
文章摘录数: 636
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1500; 图 5j
Xia R, Liu T, Li W, Xu X. RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA. Clin Transl Med. 2021;11:e383 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 7c
  • 免疫印迹; 人类; 1:1000; 图 5a
Xu Y, Chen X, Pan S, Wang Z, Zhu X. TM7SF2 regulates cell proliferation and apoptosis by activation of C-Raf/ERK pathway in cervical cancer. Cell Death Discov. 2021;7:299 pubmed 出版商
  • 免疫印迹; 小鼠
Ma S, Xu H, Huang W, Gao Y, Zhou H, Li X, et al. Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation. Front Physiol. 2021;12:706359 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Gao C, Deng J, Zhang H, Li X, Gu S, Zheng M, et al. HSPA13 facilitates NF-κB-mediated transcription and attenuates cell death responses in TNFα signaling. Sci Adv. 2021;7:eabh1756 pubmed 出版商
  • 免疫印迹; 人类; 图 5g
Lü Z, Liu H, Song N, Liang Y, Zhu J, Chen J, et al. METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1. Cell Death Dis. 2021;12:881 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5b
  • 免疫印迹; 大鼠; 1:2000; 图 1e
Li W, Lin Y, Luo Y, Wang Y, Lu Y, Li Y, et al. Vitamin D Receptor Protects against Radiation-Induced Intestinal Injury in Mice via Inhibition of Intestinal Crypt Stem/Progenitor Cell Apoptosis. Nutrients. 2021;13: pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 5f
Gahankari A, Dong C, Bartoletti G, Galazo M, He F. Deregulated Rac1 Activity in Neural Crest Controls Cell Proliferation, Migration and Differentiation During Midbrain Development. Front Cell Dev Biol. 2021;9:704769 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1e, 1h
Xue Y, Morris J, Yang K, Fu Z, Zhu X, Johnson F, et al. SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria. Nat Commun. 2021;12:5404 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 4a
Rossino M, Amato R, Amadio M, Rosini M, Basagni F, Cammalleri M, et al. A Nature-Inspired Nrf2 Activator Protects Retinal Explants from Oxidative Stress and Neurodegeneration. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 7e
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson M, Schmitz W, Wach S, et al. MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Nat Commun. 2021;12:5066 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Yuan T, Annamalai K, Naik S, Lupse B, Geravandi S, Pal A, et al. The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. Nat Commun. 2021;12:4928 pubmed 出版商
  • 免疫组化; 小鼠; 1:2000; 图 4f
Maurizy C, Abeza C, Lemmers B, Gabola M, Longobardi C, Pinet V, et al. The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium. Nat Commun. 2021;12:4810 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2b
He Y, Li H, Yao J, Zhong H, Kuang Y, Li X, et al. HO‑1 knockdown upregulates the expression of VCAM‑1 to induce neutrophil recruitment during renal ischemia‑reperfusion injury. Int J Mol Med. 2021;48: pubmed 出版商
  • 免疫印迹; 人类
Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, et al. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021;7: pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, et al. Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes. Cell Rep. 2021;36:109490 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5b
Oh H, Choi A, Seo N, Lim J, You J, Chung Y. Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on post-contrast acute kidney injury. Sci Rep. 2021;11:15625 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1e
Clark A, Kugathasan U, Baskozos G, Priestman D, Fugger N, Lone M, et al. An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions. Cell Rep Med. 2021;2:100345 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 s3b
Shao C, Lou P, Liu R, Bi X, Li G, Yang X, et al. Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland. Front Cell Dev Biol. 2021;9:691050 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5b
Lin X, Wang C, Zhang Q, Pan Y, Dang S, Zhang W. ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice. Reprod Biol. 2021;21:100537 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1d
Hao L, Zhong W, Sun X, Zhou Z. TLR9 Signaling Protects Alcohol-Induced Hepatic Oxidative Stress but Worsens Liver Inflammation in Mice. Front Pharmacol. 2021;12:709002 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 3a
Beaulac H, Gilels F, Zhang J, Jeoung S, White P. Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice. Cell Death Dis. 2021;12:682 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Lee S, Jung J, Lee Y, Kim S, Kim J, Kim B, et al. Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer. Cancers (Basel). 2021;13: pubmed 出版商
  • 免疫组化; 小鼠; 图 2c
  • 免疫印迹; 小鼠; 1:1000; 图 2a, 2b
  • 免疫印迹; 人类; 图 2e
Fisher A, Sangkhae V, Balusikova K, Palaskas N, Ganz T, Nemeth E. Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy. Nat Commun. 2021;12:4026 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 9b
Mu X, Tu Z, Chen X, Hong Y, Geng Y, Zhang Y, et al. In utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice. Front Cell Dev Biol. 2021;9:669732 pubmed 出版商
  • 免疫组化; 人类; 图 s6g
  • 免疫印迹; 人类; 图 5d
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, et al. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 2021;12:3651 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 8a
Liu C, Chi K, Geng X, Hong Q, Mao Z, Huang Q, et al. Exogenous Biological Renal Support Improves Kidney Function in Mice With Rhabdomyolysis-Induced Acute Kidney Injury. Front Med (Lausanne). 2021;8:655787 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 6d
Zhang J, Terán G, Popa M, Madapura H, Ladds M, Lianoudaki D, et al. DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance. iScience. 2021;24:102494 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 1c, 5b
Lasierra Losada M, Pauler M, Vandamme N, Goossens S, Berx G, Leppkes M, et al. Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells. Cell Death Discov. 2021;7:138 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 1f
  • 免疫印迹; 小鼠; 1:500; 图 1c
Yan C, Saleh N, Yang J, Nebhan C, Vilgelm A, Reddy E, et al. Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade. Mol Cancer. 2021;20:85 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 1h
Wu Y, Xie L, Hua Y, Xu H, Chen G, Han X, et al. Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling. Front Pharmacol. 2021;12:644116 pubmed 出版商
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Ray U, Roy D, Jin L, Thirusangu P, Staub J, Xiao Y, et al. Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization. J Exp Clin Cancer Res. 2021;40:182 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 3d
Kemp S, Carpenter E, Steele N, Donahue K, Nwosu Z, Pacheco A, et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021;81:4305-4318 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:800; 图 8g
Ma X, Zhao T, Yan H, Guo K, Liu Z, Wei L, et al. Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma. Cell Death Dis. 2021;12:544 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s4c
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 6b
Misra J, Holmes M, T Mirek E, Langevin M, Kim H, Carlson K, et al. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021;49:5726-5742 pubmed 出版商
  • 免疫印迹; 人类; 图 8b
Sun L, Liu S, Wang X, Zheng X, Chen Y, Shen H. eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway. J Transl Med. 2021;19:216 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 4g
Filppu P, Tanjore Ramanathan J, Granberg K, Gucciardo E, Haapasalo H, Lehti K, et al. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight. 2021;6: pubmed 出版商
  • 免疫印迹; 小鼠; 图 4h
Liu Y, Cong P, Zhang T, Wang R, Wang X, Liu J, et al. Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition. Redox Biol. 2021;43:102002 pubmed 出版商
  • 免疫组化; 小鼠; 1:50; 图 1g
Liberti D, Kremp M, Liberti W, Penkala I, Li S, Zhou S, et al. Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury. Cell Rep. 2021;35:109092 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Liu Y, Xu S, Zhang H, Qian K, Huang J, Gu X, et al. Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis. Cell Death Dis. 2021;12:448 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:50; 图 1e
Nasu M, Esumi S, Hatakeyama J, Tamamaki N, Shimamura K. Two-Phase Lineage Specification of Telencephalon Progenitors Generated From Mouse Embryonic Stem Cells. Front Cell Dev Biol. 2021;9:632381 pubmed 出版商
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Chen X, Ma W, Yao Y, Zhang Q, Li J, Wu X, et al. Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways. Cell Death Dis. 2021;12:425 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2b
Lu H, Hsu H, Li C, Li S, Lin S, Shih C, et al. Hydrogen Sulfide Attenuates Aortic Remodeling in Aortic Dissection Associating with Moderated Inflammation and Oxidative Stress through a NO-Dependent Pathway. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 免疫印迹; 人类; 图 1d
Nakajima W, Miyazaki K, Asano Y, Kubota S, Tanaka N. Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells. Genes (Basel). 2021;12: pubmed 出版商
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Li X, Huang K, Liu X, Ruan H, Ma L, Liang J, et al. Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway. Front Pharmacol. 2021;12:639574 pubmed 出版商
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Tian F, Zhang Y. Overexpression of SERCA2a Alleviates Cardiac Microvascular Ischemic Injury by Suppressing Mfn2-Mediated ER/Mitochondrial Calcium Tethering. Front Cell Dev Biol. 2021;9:636553 pubmed 出版商
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Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, et al. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021;12:2259 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 1g
Shu H, Guo Z, Chen X, Qi S, Xiong X, Xia S, et al. Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice. Aging Dis. 2021;12:371-385 pubmed 出版商
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Andrade J, Shi C, Costa A, Choi J, Kim J, Doddaballapur A, et al. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021;23:413-423 pubmed 出版商
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Nishad R, Mukhi D, Singh A, Motrapu M, Chintala K, Tammineni P, et al. Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria. Cell Death Dis. 2021;12:342 pubmed 出版商
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Wang F, Gervasi M, Boskovic A, Sun F, Rinaldi V, Yu J, et al. Deficient spermiogenesis in mice lacking Rlim. elife. 2021;10: pubmed 出版商
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Lu M, Qin X, Zhou Y, Li G, Liu Z, Geng X, et al. Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis. Cell Death Dis. 2021;12:72 pubmed 出版商
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Jubair L, Lam A, Fallaha S, McMillan N. CRISPR/Cas9-loaded stealth liposomes effectively cleared established HPV16-driven tumours in syngeneic mice. PLoS ONE. 2021;16:e0223288 pubmed 出版商
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Hasenpusch Theil K, Laclef C, Colligan M, Fitzgerald E, Howe K, Carroll E, et al. A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. elife. 2020;9: pubmed 出版商
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Chen T, Lennon V, Liu Y, Bosco D, Li Y, Yi M, et al. Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion. J Clin Invest. 2020;130:4025-4038 pubmed 出版商
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Hernández I, Cabrera J, Santos Galindo M, Sanchez Martin M, Dominguez V, García Escudero R, et al. Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism. Brain. 2020;143:2207-2219 pubmed 出版商
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Kyprianou C, Christodoulou N, Hamilton R, Nahaboo W, Boomgaard D, Amadei G, et al. Basement membrane remodelling regulates mouse embryogenesis. Nature. 2020;582:253-258 pubmed 出版商
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Arai S, Varkaris A, Nouri M, Chen S, Xie L, Balk S. MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. elife. 2020;9: pubmed 出版商
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Nava M, Miroshnikova Y, Biggs L, Whitefield D, Metge F, Boucas J, et al. Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell. 2020;181:800-817.e22 pubmed 出版商
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Li M, Li C, Ye Z, Huang J, Li Y, Lai W, et al. Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice. J Cell Mol Med. 2020;24:5109-5121 pubmed 出版商
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Zhao J, Li G, Zhao X, Lin X, Gao Y, Raimundo N, et al. Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss. Aging (Albany NY). 2020;12:5590-5611 pubmed 出版商
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Ruscetti M, Morris J, Mezzadra R, Russell J, Leibold J, Romesser P, et al. Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Cell. 2020;181:424-441.e21 pubmed 出版商
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Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, et al. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma. Theranostics. 2020;10:3351-3365 pubmed 出版商
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Mukhtar T, Breda J, Grison A, Karimaddini Z, Grobecker P, Iber D, et al. Tead transcription factors differentially regulate cortical development. Sci Rep. 2020;10:4625 pubmed 出版商
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Wang Bishop L, Wehbe M, Shae D, James J, Hacker B, Garland K, et al. Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma. J Immunother Cancer. 2020;8: pubmed 出版商
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Chu S, Chabon J, Matovina C, Minehart J, Chen B, Zhang J, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020;23:100941 pubmed 出版商
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Chappell G, Thompson C, Wolf J, Cullen J, Klaunig J, Haws L. Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks. Toxicol Pathol. 2020;48:494-508 pubmed 出版商
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Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, et al. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 2020;53:102679 pubmed 出版商
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产品信息
SKU号 :
9664S
产品名称 :
切断的胱氨酸-天冬氨酸蛋白酶3(Asp175)(5A1E)兔单克隆抗体
规格 :
100微升
Price-(USD) :
274美元
物种x :
H, M, R, Mk, (Dg)
应用 :
流式细胞仪
产品种类 :
凋亡
运输温度 :
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
17, 19
宿主 :
靶标 :
Casp3(Asp175)切断的
最初蛋白 :
Casp3
别名 :
Apopain,CASP-3,CASP3,CPP-32,CPP32,CPP32B,Caspase-3,Caspase-3 subunit p12,Caspase-3 subunit p17,Cysteine protease CPP32,PARP cleavage protease,Protein Yama,SCA-1,SREBP cleavage activity 1,Yama,caspase 3, apoptosis-related cysteine peptidase,caspase 3, apoptosis-related cysteine protease,procaspase3
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。