产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
磷酸化组蛋白H2A.X(Ser139)(20E3)兔单克隆抗体
目录 :
9718
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
20E3
反应物种 :
African green monkey, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
文章摘录数: 264
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 s4b
Yang K, Han J, Gill J, Park J, Sathe M, Gattineni J, et al. The mammalian SKIV2L RNA exosome is essential for early B cell development. Sci Immunol. 2022;7:eabn2888 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2d, 2e
Cui J, Dean D, Hornicek F, Pollock R, Hoffman R, Duan Z. ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage. Am J Cancer Res. 2022;12:1577-1592 pubmed
  • 免疫细胞化学; 人类; 1:400; 图 s8c, s9a
Zhou W, Xu Y, Zhang J, Zhang P, Yao Z, Yan Z, et al. MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma. Leukemia. 2022;36:1861-1869 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200; 图 4d
  • 免疫组化; 小鼠; 1:200; 图 3i
Guo T, Han X, He J, Feng J, Jing J, Jane x10d kov xe1 E, et al. KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. elife. 2022;11: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:300; 图 s1e
Groelly F, Porru M, Zimmer J, Benainous H, De Visser Y, Kosova A, et al. Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours. EMBO Mol Med. 2022;14:e14501 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3f
Meinhardt A, Munkhbaatar E, Höckendorf U, Dietzen M, Dechant M, Anton M, et al. The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner. Oncogene. 2022;41:1376-1382 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 6e
Jiang Z, Li H, Schroer S, Voisin V, Ju Y, Pacal M, et al. Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes. EMBO J. 2022;41:e106825 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 7e
Fernández Duran I, Quintanilla A, Tarrats N, Birch J, Hari P, Millar F, et al. Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. Cell Death Differ. 2022;29:1267-1282 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Chesnokova V, Zonis S, Apostolou A, Estrada H, Knott S, Wawrowsky K, et al. Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Cell Rep. 2021;37:110068 pubmed 出版商
  • 免疫印迹; 人类; 1:2500; 图 5j
Xia R, Liu T, Li W, Xu X. RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA. Clin Transl Med. 2021;11:e383 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:400; 图 1a
Li W, Lin Y, Luo Y, Wang Y, Lu Y, Li Y, et al. Vitamin D Receptor Protects against Radiation-Induced Intestinal Injury in Mice via Inhibition of Intestinal Crypt Stem/Progenitor Cell Apoptosis. Nutrients. 2021;13: pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Langdon C, Gadek K, Garcia M, Evans M, Reed K, Bush M, et al. Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. Nat Commun. 2021;12:5520 pubmed 出版商
  • 免疫组化; 小鼠; 1:50; 图 s2c
Novais E, Tran V, Johnston S, Darris K, Roupas A, Sessions G, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021;12:5213 pubmed 出版商
  • 免疫组化; 小鼠; 图 3d
Saha J, Bae J, Wang S, Lu H, Chappell L, Gopal P, et al. Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma. Nucleic Acids Res. 2021;49:9836-9850 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s9b
Laine A, Nagelli S, Farrington C, Butt U, Cvrljevic A, Vainonen J, et al. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021;81:4319-4331 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2h
Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, et al. CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice. Signal Transduct Target Ther. 2021;6:223 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1j
Kim C, Jin J, Ye Z, Jadhav R, Gustafson C, Hu B, et al. Histone deficiency and accelerated replication stress in T cell aging. J Clin Invest. 2021;131: pubmed 出版商
  • 免疫印迹; 人类; 图 5l
Pettinato A, Yoo D, VanOudenhove J, Chen Y, Cohn R, Ladha F, et al. Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Cell Rep. 2021;35:109088 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 1f
Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, et al. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021;12:2259 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2g
Park K, Ryoo J, Jeong H, Kim M, Lee S, Hwang S, et al. Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription-replication conflict regions. PLoS Genet. 2021;17:e1009523 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1d
Corbin J, Georgescu C, Wren J, Xu C, Asch A, Ruiz Echevarría M. Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells. Mol Ther Nucleic Acids. 2021;24:337-351 pubmed 出版商
  • 免疫组化; 小鼠; 1:480; 图 4a
Zhang J, Saravanabavan S, Rangan G. Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease. Cells. 2021;10: pubmed 出版商
  • 流式细胞仪; 人类; 图 2a
Ditano J, Donahue K, Tafe L, McCleery C, Eastman A. Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Sci Rep. 2021;11:7077 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 3e
Lagnado A, Leslie J, Ruchaud Sparagano M, Victorelli S, Hirsova P, Ogrodnik M, et al. Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. EMBO J. 2021;40:e106048 pubmed 出版商
  • 免疫组化; 小鼠; 图 2a
Swiader A, Camaré C, Guerby P, Salvayre R, Negre Salvayre A. 4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 5d
  • 免疫细胞化学; 人类; 1:500; 图 1b
Grimley E, Cole A, Luong T, McGonigal S, Sinno S, Yang D, et al. Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors. Theranostics. 2021;11:3540-3551 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 s3f
Evstatiev R, Cervenka A, Austerlitz T, Deim G, Baumgartner M, Beer A, et al. The food additive EDTA aggravates colitis and colon carcinogenesis in mouse models. Sci Rep. 2021;11:5188 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 6a
Chen J, Liu Z, Wang H, Qian L, Li Z, Song Q, et al. SIRT6 enhances telomerase activity to protect against DNA damage and senescence in hypertrophic ligamentum flavum cells from lumbar spinal stenosis patients. Aging (Albany NY). 2021;13:6025-6040 pubmed 出版商
  • 免疫印迹; 小鼠; 1:100
Klemke L, De Oliveira T, Witt D, Winkler N, Bohnenberger H, Bucala R, et al. Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer. Cell Death Dis. 2021;12:155 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4e, e7b
Yuan G, Flores N, Hausmann S, Lofgren S, Kharchenko V, Angulo Ibáñez M, et al. Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature. 2021;590:504-508 pubmed 出版商
  • 免疫印迹; 人类; 图 6g
Chi R, van der Watt P, Wei W, Birrer M, Leaner V. Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer. BMC Cancer. 2021;21:106 pubmed 出版商
  • 免疫印迹; 人类; 图 6g
Nabil M, El Raey M, Abdo W, Abdelfattah M, El Shazly A, Sobeh M, et al. Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 免疫细胞化学; 人类; 图 1e
Chen F, Xu B, Li J, Yang X, Gu J, Yao X, et al. Hypoxic tumour cell-derived exosomal miR-340-5p promotes radioresistance of oesophageal squamous cell carcinoma via KLF10. J Exp Clin Cancer Res. 2021;40:38 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 4a
Wang F, Zhang Y, Shen J, Yang B, Dai W, Yan J, et al. The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway. Cell Mol Gastroenterol Hepatol. 2021;11:1369-1385 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 s4d
Chen W, Wu Y, Tsai T, Li R, Lai A, Li L, et al. Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis. Theranostics. 2021;11:2594-2611 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Wen Y, Hou Y, Yi X, Sun S, Guo J, He X, et al. EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells. Theranostics. 2021;11:1795-1813 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6b
Lei H, Xu H, Shan H, Liu M, Lu Y, Fang Z, et al. Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia. Nat Commun. 2021;12:51 pubmed 出版商
  • 免疫印迹; 人类; 图 1e
Tothova Z, Valton A, Gorelov R, Vallurupalli M, Krill Burger J, Holmes A, et al. Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML. JCI Insight. 2021;6: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5g
Humpton T, Nomura K, Weber J, Magnussen H, Hock A, Nixon C, et al. Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes Dev. 2021;35:117-132 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:300; 图 5d
Horiuchi M, Taguchi K, Hirose W, Tsuchida K, Suzuki M, Taniyama Y, et al. Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium. Mol Cell Biol. 2021;41: pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1c
  • 免疫组化; 小鼠; 图 1a
  • 免疫印迹; 小鼠; 图 1b
Zhang D, Liu C, Li H, Jiao J. Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors. Adv Sci (Weinh). 2020;7:2002117 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5g
Guo H, Chou W, Lai Y, Liang K, Tam J, Brickey W, et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020;370: pubmed 出版商
  • 免疫印迹; 人类; 1:700; 图 s3-3b
Hao Q, Zong X, Sun Q, Lin Y, Song Y, Hashemikhabir S, et al. The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Moses N, Zhang M, Wu J, Hu C, Xiang S, Geng X, et al. HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1. Cells. 2020;9: pubmed 出版商
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  • 免疫印迹; 人类; 1:1000; 图 5c
Jin H, Wang S, Zaal E, Wang C, Wu H, Bosma A, et al. A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer. elife. 2020;9: pubmed 出版商
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Wertman J, Melong N, Stoyek M, Piccolo O, Langley S, Orr B, et al. The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model. elife. 2020;9: pubmed 出版商
  • 流式细胞仪; 人类; 图 1f, 3s2b
  • 免疫细胞化学; 人类; 图 2s2d, 3s2c
  • 免疫印迹; 人类; 图 1s1e, 1s1g, 3g
Brunner A, Suryo Rahmanto A, Johansson H, Franco M, Viiliäinen J, Gazi M, et al. PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer. elife. 2020;9: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 2g
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Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020;11:3018 pubmed 出版商
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Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, et al. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma. Theranostics. 2020;10:3351-3365 pubmed 出版商
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Gallo S, Spilinga M, Albano R, Ferrauto G, Di Gregorio E, Casanova E, et al. Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro. Br J Pharmacol. 2020;177:3107-3122 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 5c
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Li K, Zhao S, Long J, Su J, Wu L, Tao J, et al. A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products. Cancer Cell Int. 2020;20:36 pubmed 出版商
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Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577:676-681 pubmed 出版商
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Sharma S, Plotkin M. Id1 expression in kidney endothelial cells protects against diabetes-induced microvascular injury. FEBS Open Bio. 2020;: pubmed 出版商
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Gross K, Zhou W, Breindel J, Ouyang J, Jin D, Sokol E, et al. Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. Cell Rep. 2019;28:394-407.e6 pubmed 出版商
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Zhang J, Lee Y, Dang F, Gan W, Menon A, Katon J, et al. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019;: pubmed 出版商
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Hsu C, Altschuler S, Wu L. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019;: pubmed 出版商
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Wen H, Gao S, Wang Y, Ray M, Magnuson M, Wright C, et al. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed 出版商
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Singh R, Peng S, Viswanath P, Sambandam V, Shen L, Rao X, et al. Non-canonical cMet regulation by vimentin mediates Plk1 inhibitor-induced apoptosis. EMBO Mol Med. 2019;: pubmed 出版商
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Kucab J, Zou X, Morganella S, Joel M, Nanda A, Nagy E, et al. A Compendium of Mutational Signatures of Environmental Agents. Cell. 2019;177:821-836.e16 pubmed 出版商
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Chan E, Shibue T, McFarland J, Gaeta B, Ghandi M, Dumont N, et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019;568:551-556 pubmed 出版商
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Liu X, Chen H, Hou Y, Ma X, Ye M, Huang R, et al. Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway. Int J Oncol. 2019;54:1466-1480 pubmed 出版商
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Liu W, Wang G, Palovcak A, Li Y, Hao S, Liu Z, et al. Impeding the single-strand annealing pathway of DNA double-strand break repair by withaferin A-mediated FANCA degradation. DNA Repair (Amst). 2019;77:10-17 pubmed 出版商
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Fu T, Coulter S, Yoshihara E, Oh T, Fang S, Cayabyab F, et al. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 2019;176:1098-1112.e18 pubmed 出版商
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Zhang Q, Ji S, Busayavalasa K, Yu C. SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. Sci Adv. 2019;5:eaau9780 pubmed 出版商
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Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, et al. Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. EMBO J. 2019;38: pubmed 出版商
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Gronke K, Hernandez P, Zimmermann J, Klose C, Kofoed Branzk M, Guendel F, et al. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature. 2019;566:249-253 pubmed 出版商
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  • 免疫印迹; 人类; 图 7d
Xie Y, Fan H, Lu W, Yang Q, Nurkesh A, Yeleussizov T, et al. Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer. Oncogene. 2019;38:2967-2983 pubmed 出版商
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Bonath F, Domingo Prim J, Tarbier M, Friedländer M, Visa N. Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks. Nucleic Acids Res. 2018;46:11869-11882 pubmed 出版商
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Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, et al. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2019;38:1905-1919 pubmed 出版商
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Craxton A, Munnur D, Jukes Jones R, Skalka G, Langlais C, Cain K, et al. PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair. Nat Commun. 2018;9:3877 pubmed 出版商
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Saldivar J, Hamperl S, Bocek M, Chung M, Bass T, Cisneros Soberanis F, et al. An intrinsic S/G2 checkpoint enforced by ATR. Science. 2018;361:806-810 pubmed 出版商
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Lee C, Hsieh T. Wuho/WDR4 deficiency inhibits cell proliferation and induces apoptosis via DNA damage in mouse embryonic fibroblasts. Cell Signal. 2018;47:16-26 pubmed 出版商
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产品信息
SKU号 :
9718S
产品名称 :
磷酸化组蛋白H2A.X(Ser139)(20E3)兔单克隆抗体
规格 :
100微升
Price-(USD) :
274美元
物种x :
H, M, R, Mk
应用 :
流式细胞仪
产品种类 :
Chromatin Regulation / Nuclear Function
运输温度 :
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
15
宿主 :
靶标 :
H2A组蛋白家族成员X(Ser140)磷酸盐
最初蛋白 :
H2A组蛋白家族成员X
别名 :
H2A histone family, member X,H2A.X,H2AFX,H2AX,H2AX histone,H2a/x,Histone H2A.x
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。