产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
磷酸化eIF2α(Ser51)抗体
目录 :
9721
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼, brewer's yeast, fruit fly
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
文章摘录数: 50
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 2g
Lee Y, Gil E, Jeong I, Kim H, Jang J, Choung Y. Heat Shock Factor 1 Prevents Age-Related Hearing Loss by Decreasing Endoplasmic Reticulum Stress. Cells. 2021;10: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1b
Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, et al. ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model. Mol Metab. 2021;54:101338 pubmed 出版商
  • 免疫印迹; 人类; 图 3e
Guo Y, Hinchman M, Lewandrowski M, Cross S, Sutherland D, Welsh O, et al. The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. PLoS Pathog. 2021;17:e1009494 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3d
Torres A, Rodríguez Escribà M, Marcet Houben M, Santos Vieira H, Camacho N, Catena H, et al. Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins. Nucleic Acids Res. 2021;49:7011-7034 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 6a
Li L, Yang L, Yang F, Zhao X, Xue S, Gong F. Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice. J Inflamm Res. 2021;14:1959-1971 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4d
Tripathi P, Guo H, Dreser A, Yamoah A, Sechi A, Jesse C, et al. Pathomechanisms of ALS8: altered autophagy and defective RNA binding protein (RBP) homeostasis due to the VAPB P56S mutation. Cell Death Dis. 2021;12:466 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2a
Lu Y, Kavianpour S, Zhang T, Zhang X, Nguyen D, Thombre R, et al. MARK2 phosphorylates eIF2α in response to proteotoxic stress. PLoS Biol. 2021;19:e3001096 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4b
Yagisawa Y, Suita K, Ohnuki Y, Ishikawa M, Mototani Y, Ito A, et al. Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice. PLoS ONE. 2020;15:e0236547 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2b
Arai S, Varkaris A, Nouri M, Chen S, Xie L, Balk S. MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 大鼠; 图 5c
  • 免疫印迹; 小鼠; 图 5a
Peng Z, Aggarwal R, Zeng N, He L, Stiles E, Debebe A, et al. AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic β Cells. Mol Cell Biol. 2020;40: pubmed 出版商
  • 免疫印迹; fruit fly ; 1:1000; 图 1b, 3a
Elvira R, Cha S, Noh G, Kim K, Han J. PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila. Int J Mol Sci. 2020;21: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2d
Pakarinen E, Danilova T, Voikar V, Chmielarz P, Piepponen P, Airavaara M, et al. MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. Eneuro. 2020;7: pubmed 出版商
  • 免疫印迹; 人类; 图 s4e
Manjunath H, Zhang H, Rehfeld F, Han J, Chang T, Mendell J. Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection. Cell Rep. 2019;29:3134-3146.e6 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 1e
Abdel Nour M, Carneiro L, Downey J, Tsalikis J, Outlioua A, Prescott D, et al. The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling. Science. 2019;365: pubmed 出版商
  • 免疫印迹; brewer's yeast; 1:1000; 图 1s1c
Gupta R, Walvekar A, Liang S, Rashida Z, Shah P, Laxman S. A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6a
Das R, Schwintzer L, Vinopal S, Roca E, Sylvester M, Oprişoreanu A, et al. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. J Cell Sci. 2019;: pubmed 出版商
  • 免疫印迹; 小鼠; 图 2a
Hernández Alvarez M, Sebastian D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, et al. Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell. 2019;177:881-895.e17 pubmed 出版商
  • 免疫印迹; 人类; 图 1d
Garcia Moreno M, Noerenberg M, Ni S, Järvelin A, González Almela E, Lenz C, et al. System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection. Mol Cell. 2019;74:196-211.e11 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Wang D, Xu Q, Yuan Q, Jia M, Niu H, Liu X, et al. Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab. Oncogene. 2019;38:3458-3474 pubmed 出版商
  • 免疫印迹; 小鼠; 1:100; 图 6a
López Erauskin J, Tadokoro T, Baughn M, Myers B, McAlonis Downes M, Chillon Marinas C, et al. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018;100:816-830.e7 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Makhov P, Naito S, Haifler M, Kutikov A, Boumber Y, Uzzo R, et al. The convergent roles of NF-κB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma. Cell Death Dis. 2018;9:374 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, et al. Picornavirus 2A protease regulates stress granule formation to facilitate viral translation. PLoS Pathog. 2018;14:e1006901 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 9e
Tseng K, Danilova T, Domanskyi A, Saarma M, Lindahl M, Airavaara M. MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex. Eneuro. 2017;4: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4c
Amici D, Pinal Fernández I, Mázala D, Lloyd T, Corse A, Christopher Stine L, et al. Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis. Acta Neuropathol Commun. 2017;5:24 pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Sanchez Martin M, Ambesi Impiombato A, Qin Y, Herranz D, Bansal M, Girardi T, et al. Synergistic antileukemic therapies in NOTCH1-induced T-ALL. Proc Natl Acad Sci U S A. 2017;114:2006-2011 pubmed 出版商
  • 免疫印迹; 人类; 图 s2c
Nita I, Hostettler K, Tamo L, Medová M, Bombaci G, Zhong J, et al. Hepatocyte growth factor secreted by bone marrow stem cell reduce ER stress and improves repair in alveolar epithelial II cells. Sci Rep. 2017;7:41901 pubmed 出版商
  • 免疫印迹; brewer's yeast; 图 3e
Weisshaar N, Welsch H, Guerra Moreno A, Hanna J. Phospholipase Lpl1 links lipid droplet function with quality control protein degradation. Mol Biol Cell. 2017;28:716-725 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, et al. Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. J Neuroinflammation. 2017;14:9 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3a
Krawczyk K, Ekman M, Rippe C, Grossi M, Nilsson B, Albinsson S, et al. Assessing the contribution of thrombospondin-4 induction and ATF6? activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction. Sci Rep. 2016;6:32449 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 4
Plate L, Cooley C, Chen J, Paxman R, Gallagher C, Madoux F, et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. elife. 2016;5: pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 s5
  • 免疫组化; 小鼠; 1:1000; 图 s6
  • 免疫印迹; 小鼠; 1:1000; 图 7
Jiang M, Liu L, He X, Wang H, Lin W, Wang H, et al. Regulation of PERK-eIF2? signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes. Nat Commun. 2016;7:12185 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Ansari M, Haqqi T. Interleukin-1β induced Stress Granules Sequester COX-2 mRNA and Regulates its Stability and Translation in Human OA Chondrocytes. Sci Rep. 2016;6:27611 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Yalon M, Tuval Kochen L, Castel D, Moshe I, Mazal I, Cohen O, et al. Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations. PLoS ONE. 2016;11:e0155711 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4
Chen Y, Pandiri I, Joe Y, Kim H, Kim S, Park J, et al. Synergistic Effects of Cilostazol and Probucol on ER Stress-Induced Hepatic Steatosis via Heme Oxygenase-1-Dependent Activation of Mitochondrial Biogenesis. Oxid Med Cell Longev. 2016;2016:3949813 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2d
Soeda J, Mouralidarane A, Cordero P, Li J, Nguyen V, Carter R, et al. Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas. J Physiol Biochem. 2016;72:281-91 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Ben Sahra I, Hoxhaj G, Ricoult S, Asara J, Manning B. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 2016;351:728-733 pubmed 出版商
  • 免疫印迹; 斑马鱼; 图 s7
Hu M, Bai Y, Zhang C, Liu F, Cui Z, Chen J, et al. Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. PLoS Genet. 2016;12:e1005881 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Liao B, McManus S, Hughes W, Schmitz Peiffer C. Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes. Mol Endocrinol. 2016;30:417-28 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Arimoto Matsuzaki K, Saito H, Takekawa M. TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis. Nat Commun. 2016;7:10252 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
McIlroy G, Tammireddy S, Maskrey B, Grant L, Doherty M, Watson D, et al. Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue. Biochem Pharmacol. 2016;100:86-97 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1A
  • 免疫印迹; 小鼠; 图 1C
Zismanov V, Chichkov V, Colangelo V, Jamet S, Wang S, Syme A, et al. Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal. Cell Stem Cell. 2016;18:79-90 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2a
  • 免疫印迹; 小鼠; 1:500; 图 1b
Zhu X, Zelmer A, Kapfhammer J, Wellmann S. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. FASEB J. 2016;30:624-34 pubmed 出版商
Poli M, Ebstein F, Nicholas S, de Guzman M, Forbes L, Chinn I, et al. Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome. Am J Hum Genet. 2018;102:1126-1142 pubmed 出版商
Chou A, Krukowski K, Jopson T, Zhu P, Costa Mattioli M, Walter P, et al. Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proc Natl Acad Sci U S A. 2017;114:E6420-E6426 pubmed 出版商
Kim H, Joe Y, Kim S, Park S, Park J, Chen Y, et al. Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2?-ATF4 pathway. Free Radic Biol Med. 2017;110:81-91 pubmed 出版商
Zaini M, Muller C, Ackermann T, Reinshagen J, Kortman G, Pless O, et al. A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties. Sci Rep. 2017;7:42603 pubmed 出版商
Geraghty P, Baumlin N, SALATHE M, Foronjy R, D Armiento J. Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure. Mediators Inflamm. 2016;2016:9461289 pubmed 出版商
Fuhrmeister J, Zota A, Sijmonsma T, Seibert O, Cıngır Å, Schmidt K, et al. Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health. EMBO Mol Med. 2016;8:654-69 pubmed 出版商
Gupta A, Hossain M, Miller N, Kerin M, Callagy G, Gupta S. NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer. Oncogene. 2016;35:5860-5871 pubmed 出版商
产品信息
SKU号 :
9721S
产品名称 :
磷酸化eIF2α(Ser51)抗体
规格 :
100微升
Price-(USD) :
274美元
物种x :
H, M, R, Mk, Dm
应用 :
免疫印迹
产品种类 :
Translational Control
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
多克隆抗体
分子量 :
38
宿主 :
靶标 :
eIF2A(Ser51)磷酸盐
最初蛋白 :
eIF2A
别名 :
EIF-2,EIF2,EIF2A,EIF2S1,Eukaryotic translation initiation factor 2 subunit 1,Eukaryotic translation initiation factor 2 subunit alpha,IF2A,eIF-2-alpha,eIF-2A,eIF-2alpha,eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。