| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
| Piunti A, Smith E, Morgan M, Ugarenko M, Khaltyan N, Helmin K, et al. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Sci Adv. 2019;5:eaax2887 pubmed 出版商 |
- ChIP-Seq; 小鼠; 图 5a
- 免疫印迹; 小鼠; 1:1000; 图 1b
| Lavarone E, Barbieri C, Pasini D. Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity. Nat Commun. 2019;10:1679 pubmed 出版商 |
| Li G, Ji T, Chen J, Fu Y, Hou L, Feng Y, et al. CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Cell Rep. 2017;18:1499-1511 pubmed 出版商 |
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| Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, et al. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. Proc Natl Acad Sci U S A. 2016;113:10370-5 pubmed 出版商 |
| Kawano S, Grassian A, Tsuda M, Knutson S, Warholic N, Kuznetsov G, et al. Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. PLoS ONE. 2016;11:e0158888 pubmed 出版商 |
| Fei Q, Yang X, Jiang H, Wang Q, Yu Y, Yu Y, et al. SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells. Genome Res. 2015;25:1325-35 pubmed 出版商 |
| Huang X, Shen M, Wang L, Yu F, Wu W, Liu H. Effects of tributyltin chloride on developing mouse oocytes and preimplantation embryos. Microsc Microanal. 2015;21:358-67 pubmed 出版商 |
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| Luense S, Denner P, Fernández Montalván A, Hartung I, Husemann M, Stresemann C, et al. Quantification of histone H3 Lys27 trimethylation (H3K27me3) by high-throughput microscopy enables cellular large-scale screening for small-molecule EZH2 inhibitors. J Biomol Screen. 2015;20:190-201 pubmed 出版商 |
| Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014;20:1394-6 pubmed 出版商 |
- 免疫组化-自由浮动切片; 小鼠; 1:200
- 免疫印迹; 小鼠; 1:1000
| Subbanna S, Nagre N, Shivakumar M, Umapathy N, Psychoyos D, Basavarajappa B. Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. Neuroscience. 2014;258:422-32 pubmed 出版商 |
- 免疫组化-自由浮动切片; 小鼠; 1:200
- 免疫印迹; 小鼠; 1:1000; 图 5a
| Subbanna S, Shivakumar M, Umapathy N, Saito M, Mohan P, Kumar A, et al. G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain. Neurobiol Dis. 2013;54:475-85 pubmed 出版商 |
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| Lee C, Holder M, Grau D, Saldaña Meyer R, Yu J, Ganai R, et al. Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2. Mol Cell. 2018;70:435-448.e5 pubmed 出版商 |
| Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, et al. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018;70:408-421.e8 pubmed 出版商 |
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| Barsotti A, Ryskin M, Zhong W, Zhang W, Giannakou A, Loreth C, et al. Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth. Oncotarget. 2015;6:2928-38 pubmed |
| Schmitz S, Albert M, Malatesta M, Morey L, Johansen J, Bak M, et al. Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J. 2011;30:4586-600 pubmed 出版商 |
