产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
Tri-Methyl-Histone H3 (Lys4) (C42D8) Rabbit mAb
目录 :
9751
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
C42D8
反应物种 :
人类, 小鼠, 大鼠, 黑腹果蝇
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, ChIP-Seq
文章摘录数: 54
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 2n
Leone R, Zhao L, Englert J, Sun I, Oh M, Sun I, et al. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science. 2019;366:1013-1021 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3d
  • ChIP-Seq; 小鼠; 图 3e
Eckert M, Coscia F, Chryplewicz A, Chang J, Hernandez K, Pan S, et al. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature. 2019;: pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; ; 图 4d
El Brolosy M, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, et al. Genetic compensation triggered by mutant mRNA degradation. Nature. 2019;: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5e
McBrayer S, Olenchock B, DiNatale G, Shi D, Khanal J, Jennings R, et al. Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase. Proc Natl Acad Sci U S A. 2018;115:E3741-E3748 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 3e
Andricovich J, Perkail S, Kai Y, Casasanta N, Peng W, Tzatsos A. Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors. Cancer Cell. 2018;33:512-526.e8 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 5f
Wang B, Fu X, Zhu M, Du M. Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol. 2017;9:338-349 pubmed 出版商
  • 免疫印迹; 人类; 图 s5a
Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, et al. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature. 2017;542:484-488 pubmed 出版商
  • ChIP-Seq; 人类; 图 s3b
Göllner S, Oellerich T, Agrawal Singh S, Schenk T, Klein H, Rohde C, et al. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 2017;23:69-78 pubmed 出版商
  • ChIP-Seq; 人类; 表 2
  • ChIP-Seq; 小鼠; 表 2
Busby M, Xue C, Li C, Farjoun Y, Gienger E, Yofe I, et al. Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq. Epigenetics Chromatin. 2016;9:49 pubmed
  • ChIP-Seq; 人类; 图 1i
Platt J, Salama R, Smythies J, Choudhry H, Davies J, Hughes J, et al. Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters. EMBO Rep. 2016;17:1410-1421 pubmed
  • 染色质免疫沉淀 ; 人类; 图 5a
Zhou A, Lin K, Zhang S, Chen Y, Zhang N, Xue J, et al. Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22. Nat Cell Biol. 2016;18:954-966 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 s1
Dhawan S, Dirice E, Kulkarni R, Bhushan A. Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. Diabetes. 2016;65:1208-18 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 3
Benitz S, Regel I, Reinhard T, Popp A, Schäffer I, Raulefs S, et al. Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells. Oncotarget. 2016;7:11424-33 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 1
Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, et al. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015;6:10068 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠; 图 3
Laumet G, Garriga J, Chen S, Zhang Y, Li D, Smith T, et al. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci. 2015;18:1746-55 pubmed 出版商
  • 免疫组化-石蜡切片; 黑腹果蝇; 1:200; 图 s1b
  • 免疫印迹; 黑腹果蝇; 1:1000; 图 s1a
Tarayrah L, Li Y, Gan Q, Chen X. Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity. Biol Open. 2015;4:1518-27 pubmed 出版商
  • 免疫印迹; 人类; 图 6g
Torres M, Pandita R, Kulak O, Kumar R, Formstecher E, Horikoshi N, et al. Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol. 2015;35:3633-45 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 3a
Sin H, Kartashov A, Hasegawa K, Barski A, Namekawa S. Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline. BMC Biol. 2015;13:53 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 s8
Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠
Zhang Y, Laumet G, Chen S, Hittelman W, Pan H. Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development. J Biol Chem. 2015;290:14647-55 pubmed 出版商
  • 免疫细胞化学; 人类; 图 7
  • 免疫印迹; 人类; 图 6
Hendriks I, Treffers L, Verlaan de Vries M, Olsen J, Vertegaal A. SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. Cell Rep. 2015;10:1778-1791 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Yang S, Zhang J, Zhang Y, Wan X, Zhang C, Huang X, et al. KDM1A triggers androgen-induced miRNA transcription via H3K4me2 demethylation and DNA oxidation. Prostate. 2015;75:936-46 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3
Matsuda Y, Kobayashi Ishihara M, Fujikawa D, Ishida T, Watanabe T, Yamagishi M. Epigenetic heterogeneity in HIV-1 latency establishment. Sci Rep. 2015;5:7701 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 2 ugs
Naganuma K, Hatta M, Ikebe T, Yamazaki J. Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma. BMC Cancer. 2014;14:988 pubmed 出版商
  • 免疫组化; 小鼠; 图 5
Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, et al. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014;5:5425 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3
Kumar P P, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, et al. Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. elife. 2014;3: pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Tong Q, He S, Xie F, Mochizuki K, Liu Y, Mochizuki I, et al. Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice. J Immunol. 2014;192:5012-22 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 st13
Hwang W, Jiang J, Yang S, Huang T, Lan H, Teng H, et al. MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol. 2014;16:268-80 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Chen Y, Kao S, Wang H, Yang M. Histone modification patterns correlate with patient outcome in oral squamous cell carcinoma. Cancer. 2013;119:4259-67 pubmed 出版商
Larson J, Kasper L, Paugh B, Jin H, Wu G, Kwon C, et al. Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression. Cancer Cell. 2019;35:140-155.e7 pubmed 出版商
Uchiyama R, Kupkova K, Shetty S, Linford A, Pray Grant M, Wagar L, et al. Histone H3 lysine 4 methylation signature associated with human undernutrition. Proc Natl Acad Sci U S A. 2018;115:E11264-E11273 pubmed 出版商
Giambra V, Gusscott S, Gracias D, Song R, Lam S, Panelli P, et al. Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity. Cell Stem Cell. 2018;23:714-726.e7 pubmed 出版商
Sun H, Zhao X, Zhang C, Zhang Z, Lun J, Liao W, et al. MiR-455-3p inhibits the degenerate process of chondrogenic differentiation through modification of DNA methylation. Cell Death Dis. 2018;9:537 pubmed 出版商
Agathocleous M, Meacham C, Burgess R, Piskounova E, Zhao Z, Crane G, et al. Ascorbate regulates haematopoietic stem cell function and leukaemogenesis. Nature. 2017;549:476-481 pubmed 出版商
Gong F, Clouaire T, Aguirrebengoa M, Legube G, Miller K. Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair. J Cell Biol. 2017;216:1959-1974 pubmed 出版商
Ohshima K, Nojima S, Tahara S, Kurashige M, Hori Y, Hagiwara K, et al. Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer. Sci Rep. 2017;7:45504 pubmed 出版商
Xiaojun W, Yan L, Hong X, Xianghong Z, Shifeng L, Dingjie X, et al. Acetylated ?-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica. Sci Rep. 2016;6:32257 pubmed 出版商
Mendoza Parra M, Saravaki V, Cholley P, Blum M, Billoré B, Gronemeyer H. Antibody performance in ChIP-sequencing assays: From quality scores of public data sets to quantitative certification. F1000Res. 2016;5:54 pubmed 出版商
Pandey S, Simmons G, Malyarchuk S, Calhoun T, Pruitt K. A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1. Genes Cancer. 2015;6:408-21 pubmed
Jakobsen J, Bagger F, Hasemann M, Schuster M, Frank A, Waage J, et al. Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq. BMC Genomics. 2015;16:46 pubmed 出版商
Theisen E, Gajiwala S, Bearss J, Sorna V, Sharma S, JANAT AMSBURY M. Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma. BMC Cancer. 2014;14:752 pubmed 出版商
Blattler A, Yao L, Witt H, Guo Y, Nicolet C, Berman B, et al. Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes. Genome Biol. 2014;15:469 pubmed 出版商
Ishida S, Tanaka R, Yamaguchi N, Ogata G, Mizutani T, Kawabata K, et al. Epithelial sheet folding induces lumen formation by Madin-Darby canine kidney cells in a collagen gel. PLoS ONE. 2014;9:e99655 pubmed 出版商
Miyata K, Yotsumoto F, Nam S, Odawara T, Manabe S, Ishikawa T, et al. Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma. Cancer Med. 2014;3:1159-69 pubmed 出版商
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Chen K, Johnston J, Shao W, Meier S, Staber C, Zeitlinger J. A global change in RNA polymerase II pausing during the Drosophila midblastula transition. elife. 2013;2:e00861 pubmed 出版商
Paige S, Thomas S, Stoick Cooper C, Wang H, Maves L, Sandstrom R, et al. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell. 2012;151:221-32 pubmed 出版商
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产品信息
SKU号 :
9751S
产品名称 :
Tri-Methyl-Histone H3 (Lys4) (C42D8) Rabbit mAb
规格 :
100微升
Price-(USD) :
274美元
物种x :
H, M, R, Mk, Dm, Sc, (X, Z)
应用 :
染色质免疫沉淀
产品种类 :
Chromatin Regulation / Nuclear Function
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
17
宿主 :
靶标 :
H3 (Lys5) trimethylate
最初蛋白 :
H3
别名 :
H3 histone family, member A,H3/A,H31,H3FA,H3FB,H3FC,H3FD,H3FF,H3FH,H3FI,H3FJ,H3FK,H3FL,HIST1H3A,HIST1H3B,HIST1H3C,HIST1H3D,HIST1H3E,HIST1H3F,HIST1H3G,HIST1H3H,HIST1H3I,HIST1H3J,Histone H3.1,Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l,histone 1, H3a,histone cluster 1, H3a
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。