蛋白

重组人类AR, 多聚组氨酸标签

AR-1012H

重组人类AR, 多聚组氨酸标签

Creative Biomart

AR

雄激素受体

AR; androgen receptor; KD; AIS; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; dihydrotestosterone receptor; androgen nuclear receptor variant 2; nuclear receptor subfamily 3 group C member 4;

Recombinant Human Androgen Receptor Ligand Binding Domain (650-920) was expressed in E.coli.

Recombinant Human Androgen Receptor Ligand Binding Domain (650-920) was expressed in E.coli.The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Ecoli

The protein is in 20mM Tris-HCl pH7.9,100mM NaCl, 0.2mM EDTA, 1mM DTT and 20% glycerol.

The purified AR-LBD is greater than 90% homogeneous based on SDS-PAGE analysis.

Stored at -70 C before use. Avoid repeated freeze thaw cycles.

P10275