蛋白

重组人类乙2

B2M-1905H

重组人类乙2

Creative Biomart

B2M

乙2

B2M; beta-2-microglobulin; Beta-2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin

Recombinant Human β2 Microglobulin protein was expressed in insect cells.The expressed protein was purified by a combination of ion-exchange and gel-filtration methods.

Recombinant Human β2 Microglobulin protein was expressed in insect cells.The expressed protein was purified by a combination of ion-exchange and gel-filtration methods.The major histocompatibility complex (MHC) gene locus encodes a group of highly polymorphic, cell surface proteins that play a broad role in the immune response to protein antigens. MHC molecules function by binding and presenting small antigenic protein fragments to antigen-specific receptors expressed by T cells (TCR). Class I MHC molecules consist of two separate polypeptide chains. The class I α chain is an MHC encoded, transmembrane polypeptide containing three extracellular domains: α1, α2 and α3. The second chain consists of a non-MHC encoded, 12 kDa polypeptide called β2 microglobulin (β2M). Since β2M does not contain a transmembrane domain, it associates with the a chain through non-covalent interaction. This association is important for the stability of the MHC class I structure, its peptide-loading and its ability to present peptide antigen to CD8+ T cells. β2M is relatively invariant within each species. For example, human β2M is reported to have high affinity for human and mouse MHC class I heavy chains.

昆虫细胞

0.5毫克/毫升

P61769