蛋白

Recombinant Human Beta-Site APP-Cleaving Enzyme 1

BACE1-31H

Recombinant Human Beta-Site APP-Cleaving Enzyme 1

Creative Biomart

BACE1

beta-site APP-cleaving enzyme 1

BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme;

Recombinant Human BACE-1 is expressed in E.coli containing 366 amino acids 28-393. The BACE1 is purified by proprietary chromatographic techniques.

Recombinant Human BACE-1 is expressed in E.coli containing 366 amino acids 28-393. The BACE1 is purified by proprietary chromatographic techniques.Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer"s disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. BACE1 is a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. BACE1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE-1 cleaves at the n-terminus of the a-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated c-terminal fragment which is later released by gamma-secretase.

大肠埃希杆菌

Greater than 95% as determined by SDS-PAGE.

P56817