蛋白

重组人类BRAF蛋白, 谷胱甘肽S-转移酶标签

BRAF-791H

重组人类BRAF蛋白, 谷胱甘肽S-转移酶标签

Creative Biomart

BRAF

v-raf murine sarcoma viral oncogene homolog B1

BRAF; v-raf murine sarcoma viral oncogene homolog B1; serine/threonine-protein kinase B-raf; BRAF1; p94; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p9

Recombinant Human BRAF with GST-tag at the N-terminus was expressed in Sf9 cells using a Baculovirus expression system. The molecular weight is 66 kDa.

Recombinant Human BRAF with GST-tag at the N-terminus was expressed in Sf9 cells using a Baculovirus expression system. The molecular weight is 66 kDa.BRAF is a member of the RAF family that is activated by members of the Ras family upon growth factor-induced stimulation. Active Ras can induce heterodimerization of cRaf and BRAF and this may explain the observed cooperativity of cRaf and BRaf in cells responding to growth factor signals. Activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations result in a valine to glutamic acid change at residue 599 within the activation segment of B-RAF.

35%

P15056