蛋白

重组人染色体12开放读码框5, 多聚组氨酸标签

C12orf5-3371H

重组人染色体12开放读码框5, 多聚组氨酸标签

Creative Biomart

C12orf5

染色体12开放读码框5

C12ORF5; chromosome 12 open reading frame 5; FR2BP; TIGAR; fructose-2,6-bisphosphatase TIGAR; transactivated by NS3TP2 protein; fructose-2,6-bisphosphate 2-phosphatase; probable fructose-2,6-bisphosphatase TIGAR; TP53-induced glycolysis and apoptosis regulator;

Recombinant human TIGAR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.MW = 32.6 kDa (294aa).

Recombinant human TIGAR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.MW = 32.6 kDa (294aa).TIGAR, also known as TP53-induced glycolysis and apoptosis regulator, is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. TIGAR specifically functions to block glycolysis, leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. These facts indicate that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.

Ecoli

液体。 在20 mM三羟甲基氨基甲烷氯化氢缓冲液(pH8.0)含0.2M氯化钠, 2mM DTT, 10% 甘油

90% by SDS - PAGE.

0.5毫克/毫升(由布拉德福德Bradford检测确定)

MGSSHHHHHH SSGLVPRGSH MGSHMARFAL TVVRHGETRF NKEKIIQGQG VDEPLSETGF KQAAAAGIFL NNVKFTHAFS SDLMRTKQTM HGILERSKFC KDMTVKYDSR LRERKYGVVE GKALSELRAM AKAAREECPV FTPPGGETLD QVKMRGIDFF EFLCQLILKE ADQKEQFSQG SPSNCLETSL AEIFPLGKNH SSKVNSDSGI PGLAASVLVV SHGAYMRSLF DYFLTDLKCS LPATLSRSEL MSVTPNTGMS LFIINFEEGR EVKPTVQCIC MNLQDHLNGL TETR

可以储存在+4 C短期(1-2周)。 为长期储存, 分成小份儿保存在-20 C或-70 C。 避免反复冻融

Q9NQ88