蛋白

Recombinant Human Cyclin-dependent Kinase Inhibitor 1A (p21, Cip1)

CDKN1A-169H

Recombinant Human Cyclin-dependent Kinase Inhibitor 1A (p21, Cip1)

Creative Biomart

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; cyclin-dependent kinase inhibitor 1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6;

Recombinant Human p21WAF1 protein expressed in E.coli encodes full length amino acids and has a molecular mass of 47 kDa.

Recombinant Human p21WAF1 protein expressed in E.coli encodes full length amino acids and has a molecular mass of 47 kDa.p21WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. Meanwhile, the p21WAF1 protein also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process. Evidently, inactivation of p53 disrupts the p53-dependent expression of p21WAF1. p21WAF1is a tumor suppressor involved in the pathogenesis of a variety of malignancies.

Recombinant full length human p21WAF1 protein expressed inEcoli

P38936