产品简要
公司名称 :
Creative Biomart
产品类型 :
抗体
产品名称 :
抗IGF2R多克隆抗体[生物素]
目录 :
DPABY-450
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
生物素
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 流式细胞仪
更多信息或购买 :
产品信息
猫 :
DPABY-450
产品名称 :
抗IGF2R多克隆抗体[生物素]
简称 :
抗IGF2R多克隆抗体, 生物素共轭标签
品牌 :
Creative Diagnostics
来源宿主 :
山羊
靶标 :
IGF2R
物种 :
人类
共轭标签 :
生物素
应用 :
免疫印迹, FC, 酶联免疫吸附测定(二乙基色胺)
免疫原 :
Mouse myeloma cell line NS0-derived recombinant human IGF-II R. Ser1510-Phe2108 Accession Number P11717
AntibodyIsotype :
IgG
规格 :
50微克
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
抗原描述 :
IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues.IGF-II R is a type I transmembrane glycoprotein that contains a 2,264 amino acid (aa) extracellular region, a 23 aa transmembrane segment segment and a 124 aa cytoplasmic tail. IGF-II R regulates many diverse biological functions that range from intracellular trafficking to the internalization of extracellular factors and modulation of cellular responses. It delivers newly synthesized M6P-tagged lysosomal enzymes from the trans-golgi network to endosomes, and facilitates the clearance of extracellular lysosomal and matrix degrading enzymes by internalization into clathrin-coated vesicles and delivery into endosomes. With respect to IGF-II biology, It would appear that IGF-II R is principally a regulator of local IGF-II levels, targeting IGF-II fordestruction in lysosomes.The heterotetrameric receptors for insulin (INS R) and IGF-I (IGF-I R) are receptor tyrosine kinases that consist of two ligandbindingalpha subunits and two beta subunits. Ligand binding induces autophosphorylation on multiple tyrosine residues of beta subunits. Phosphorylation of Tyr1162 and 1163 on INS R and Tyr1135 and 1136 on IGF-I R stimulates intrinsic kinase activity.
物种活性 :
人类
保存期限 :
Goat Anti-Human IGF2R polyclonal antibody for WB, FC, ELISA(Det)
基因名称 :
IGF2R胰岛素样生长因子2受体[人(人类)]
Official Symbol :
IGF2R
同义词 :
IGF2R; insulin-like growth factor 2 receptor; MPR1; MPRI; CD222; CIMPR; M6P-R; cation-independent mannose-6-phosphate receptor; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor
UniProt数据库编号 :
P11717
克隆性 :
多克隆
class3 :
Matched Antibody Pairs
class2 :
一抗
class1 :
抗体
更多信息或购买 :
公司信息
Creative Biomart
45-1 Ramsey Road Shirley
New York, NY 11967
info@creative-biomart.com
www.creativebiomart.net
1-631-559-9269
公司总部: 美国
Creative Biomart为生物研究、临床研究、分子诊断及生物药物研发等领域,提供高质量的重组蛋白、诊断用抗原抗体、诊断用酶及制药用酶等产品。