蛋白

重组人类表皮生长因子受体, 谷胱甘肽S-转移酶标签, 活性的

表皮生长因子受体-297H

重组人类表皮生长因子受体, 谷胱甘肽S-转移酶标签, 活性的

Creative Biomart

表皮生长因子受体

表皮生长因子受体

EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61

Recombinant human EGFR (695-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=89 kDa.

Recombinant human EGFR (695-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=89 kDa.EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.

Sf9 insect cellsusing baculovirus

P00533