蛋白

重组大鼠F3, 多聚组氨酸标签

F3-8802R

重组大鼠F3, 多聚组氨酸标签

Creative Biomart

F3

F3 coagulation factor III (thromboplastin, tissue factor) [ Rattus norvegicus ]

F3; coagulation factor III (thromboplastin, tissue factor); tissue factor; TF; coagulation factor 3; MGC93621;

A DNA sequence encoding the rat F3(Q66HI4)(Met1-Glu252) was expressed, fused with a polyhistidine tag at the C-terminus.

Tissue factor, also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Because of its essential role in hemostasis, Tissue factor plays a role in pathology associated with hemostasis, triggering the coagulation system in many thrombotic diseases and the coagulopathies associated with sepsis and other forms of disseminated intravascular coagulation. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes.

人类细胞

Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

>95 % as determined by SDS-PAGE

Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.