蛋白

重组人类成纤维细胞生长因子受体2, Fc嵌合体

纤维母细胞生长因子受体2-595H

重组人类成纤维细胞生长因子受体2, Fc嵌合体

Creative Biomart

纤维母细胞生长因子受体2

成纤维细胞生长因子受体2

FGFR2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; Crouzon syndrome; Pfeiffer syndrome; fibroblast growth factor receptor 2; OTTHUMP00000020623; Keratinocyte growth factor receptor; OTTHUMP00000020624; OTTHUMP00000020625; OTTHUMP00000020626; OTTHUMP00000020627; OTTHUMP00000020628; OTTHUMP00000020629; OTTHUMP00000020630; OTTHUMP00000020631; bacteria-expressed kinase; OTTHUMP00000020632; FGFR-2; BEK fibroblast growth factor receptor; FGF receptor; EC 2.7.10.1; hydroxyaryl-protein kinase; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4; craniofacial dysostosis 1; Jackson-Weiss syndrome; KSAM; CD332 antigen; FLJ98662; EC 2.7.10; OTTHUMP00000020621

Recombinant human soluble FGFR-2á (IIIc) was fused via a Xa cleavage site with the Fc part of human IgG1. Human recombinant soluble FGFR-2á (IIIc) is a disulfide-linked heterodimeric protein. The reduced form of human FGF -R2á (IIIc)/Fc is a monomer with a calculated molecular mass of approximately 66 kDa. As a result of glycosylation, the recombinant protein has a mass of 95-100 kDa. It is produced in E.coli .

Recombinant human soluble FGFR-2á (IIIc) was fused via a Xa cleavage site with the Fc part of human IgG1. Human recombinant soluble FGFR-2á (IIIc) is a disulfide-linked heterodimeric protein. The reduced form of human FGF -R2á (IIIc)/Fc is a monomer with a calculated molecular mass of approximately 66 kDa. As a result of glycosylation, the recombinant protein has a mass of 95-100 kDa. It is produced in E.coli .Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family if type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the á isoform, or only IgII and IgIII, referred to as the isoform. Only the á isoform has been identified for FGFR-3 and FGFR-4.

Ecoli

90%, by SDS-PAGE and visualised by silver stain.

P21802