蛋白

重组人类白细胞介素17A, Fc嵌合体

IL17A-279H

重组人类白细胞介素17A, Fc嵌合体

Creative Biomart

IL17A

白细胞介素17A

IL17A;白细胞介素17A;白细胞介素-17;CTLA8;IL-17;IL-17A;白细胞介素17A;CTLA-8;细胞毒性T淋巴细胞 抗原8;细胞毒性T淋巴细胞 蛋白8;白细胞介素17(细胞毒性T淋巴细胞 丝氨酸酯酶8);

Recombinant Human Interleukin 17A is produced in mammalian cells andfused with human IgG1Fc. IL-17A (C-terminus fused with human IgG1Fc) contains 361 amino acids with predicted MW 40.82kDa x 2 (dimmer) and 12 cysteines (Fc has 6). It also has 1 N-link glycosylation site with MW increase up to 5 kDa. Receptor for IL-17A induces stromal cells to produce proinflamatory and hematopoietic cytokins. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

Recombinant Human Interleukin 17A is produced in mammalian cells andfused with human IgG1Fc. IL-17A (C-terminus fused with human IgG1Fc) contains 361 amino acids with predicted MW 40.82kDa x 2 (dimmer) and 12 cysteines (Fc has 6). It also has 1 N-link glycosylation site with MW increase up to 5 kDa. Receptor for IL-17A induces stromal cells to produce proinflamatory and hematopoietic cytokins. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Mammalian cells

90%

-70 C

Q16552