蛋白

重组人类激酶插入区受体

激酶插入区受体-1265H

重组人类激酶插入区受体

Creative Biomart

激酶插入区受体激酶插入域受体(a类型III受体酪氨酸激酶)[人]

KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; EC 2.7.10.1; fetal liver kinase-1; soluble VEGFR2; tyrosine kinase growth factor receptor

Recombinant Human KDR contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding. The protein is purified by proprietary chromatographic techniques.

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas.

昆虫细胞

Greater than 95.0% as determined by SDS-PAGE.

P35968