gene symbal :
PDGFC; platelet derived growth factor C; platelet-derived growth factor C; fallotein; SCDGF; PDGF-C; VEGF-E; spinal cord-derived growth factor; secretory growth factor-like protein
Recombinant Human PDGF-C encoding the mature form of human PDGF-C (NP_057289.1) ( Val 235- Gly 345 ) was expressed with the fused Fc region of human IgG1 at the N-terminus. It was produced inHEK293.
Recombinant Human PDGF-C encoding the mature form of human PDGF-C (NP_057289.1) ( Val 235- Gly 345 ) was expressed with the fused Fc region of human IgG1 at the N-terminus. It was produced inHEK293.The human platelet-derived growth factor C (PDGF-C) is one of the four member of the PDGF family of growth factors which are known mitogens and survival factors for cells of mesenchymal origin. They form four disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and one heterodimer (PDGF-AB). PDGF-C has a unique two-domain structure consisting of an N-terminal CUB and a conserved C-terminal growth factor domain that are separated by a hinge region. PDGF-CC only binds to PDGF R with high affinity, activates the homodimerization of PDGF R , and induces the signal pathways, such as profibrotic pathways in hepatic fibrosis. PDGF-CC is involved in a variety of processes including angiogensis, morphogenesis and cardiovascular development, as well as the tumorigenesis.
97% , 根据SDS-PAGE确定
Store it under sterile conditions at -70 C. It is recommended that the protein be aliquoted for optimal storage and be used as soon as possible. Avoid repeated freeze-thaw cycles.