蛋白

Recombinant Human X-linked Inhibitor Of Apoptosis, GST-tagged

XIAP-1503H

Recombinant Human X-linked Inhibitor Of Apoptosis, GST-tagged

Creative Biomart

XIAP

X-linked inhibitor of apoptosis

XIAP; X-linked inhibitor of apoptosis; API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; E3 ubiquitin-protein ligase XIAP; X-linked IAP; IAP-like protein; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing protein 4;

Recombinant full-length human XIAP was expressed by baculovirus inSf9insect cells using a C-terminal GST tag. MW = 84 kDa.

Recombinant full-length human XIAP was expressed by baculovirus inSf9insect cells using a C-terminal GST tag. MW = 84 kDa.XIAP is a member of a family of proteins which inhibit apoptosis and act as mammalian cell-death suppressors. XIAP inhibits at least 2 members of the caspase family of cell-death proteases, caspase-3 and caspase-7. In addition, XIAP inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Furthermore, XIAP can mediate protection of cells from apoptosis by utilizing both a JNK1 activation pathway that involves ILPIP and a caspase inhibition pathway that is independent of ILPIP. Disruption of the XIAP gene in human colon cancer cells can enhance sensitivity of these cells to exogenously added TRAIL suggesting that XIAP is a nonredundant modulator of TRAIL-mediated apoptosis.

Sf9昆虫细胞美国杆状病毒

P98170