产品简要
公司名称 :
Developmental Studies Hybridoma Bank
产品类型 :
抗体
产品名称 :
Nkx2.2转录因子
目录 :
74.5A5
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
74.5A5
反应物种 :
African green monkey, 人类, 小鼠, 大鼠, , common platanna
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片
文章摘录数: 61
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 小鼠; 1:50; 图 s1a
Luisier R, Tyzack G, Hall C, Mitchell J, Devine H, Taha D, et al. Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS. Nat Commun. 2018;9:2010 pubmed 出版商
  • 免疫细胞化学; 人类; 1:250; 图 e1c
Quadrato G, Nguyen T, Macosko E, Sherwood J, Min Yang S, Berger D, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545:48-53 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 1r
Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti H, et al. Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017;8:14583 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 4i
Fujii K, Shi Z, Zhulyn O, Denans N, Barna M. Pervasive translational regulation of the cell signalling circuitry underlies mammalian development. Nat Commun. 2017;8:14443 pubmed 出版商
  • 免疫细胞化学; African green monkey; 1:50; 图 1G
  • 免疫细胞化学; 人类; 1:50; 图 4H
Yamashita T, Miyamoto Y, Bando Y, Ono T, Kobayashi S, Doi A, et al. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. PLoS ONE. 2017;12:e0171947 pubmed 出版商
  • 免疫组化-自由浮动切片; common platanna; 1:500; 表 2
Morona R, Ferran J, Puelles L, González A. Gene expression analysis of developing cell groups in the pretectal region of Xenopus laevis. J Comp Neurol. 2017;525:715-752 pubmed 出版商
  • 免疫组化; 小鼠; 1:5; 图 4
Weng C, Ding M, Chang L, Ren M, Zhang H, Lu Z, et al. Ankfy1 is dispensable for neural stem/precursor cell development. Neural Regen Res. 2016;11:1804-1809 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:10; 图 5c
Li Y, Tzatzalos E, Kwan K, Grumet M, Cai L. Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development. Sci Rep. 2016;6:38665 pubmed 出版商
  • 免疫组化; 小鼠; 图 s1
Airik R, Schueler M, Airik M, Cho J, Ulanowicz K, Porath J, et al. SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling. PLoS ONE. 2016;11:e0156081 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 s1
Xue Y, Qian H, Hu J, Zhou B, Zhou Y, Hu X, et al. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. Nat Neurosci. 2016;19:807-15 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50; 图 1
Douvaras P, Rusielewicz T, Kim K, Haines J, CASACCIA P, Fossati V. Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes. Int J Mol Sci. 2016;17: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:50; 图 st4
Dooves S, Bugiani M, Postma N, Polder E, Land N, Horan S, et al. Astrocytes are central in the pathomechanisms of vanishing white matter. J Clin Invest. 2016;126:1512-24 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 1
Grego Bessa J, Bloomekatz J, Castel P, Omelchenko T, Baselga J, Anderson K. The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. elife. 2016;5:e12034 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 5 ug/ml; 图 2
Misuraca K, Hu G, Barton K, Chung A, Becher O. A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells. Neoplasia. 2016;18:60-70 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Huettl R, Eckstein S, Stahl T, Petricca S, Ninkovic J, Götz M, et al. Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development. Dev Biol. 2016;413:86-103 pubmed 出版商
  • 免疫组化-冰冻切片; 鸡; 1:1000; 表 1
Pirson M, Debrulle S, Clippe A, Clotman F, Knoops B. Thioredoxin-2 Modulates Neuronal Programmed Cell Death in the Embryonic Chick Spinal Cord in Basal and Target-Deprived Conditions. PLoS ONE. 2015;10:e0142280 pubmed 出版商
  • 免疫组化; 鸡; 1:80; 图 1
Gallina D, Zelinka C, Cebulla C, Fischer A. Activation of glucocorticoid receptors in Müller glia is protective to retinal neurons and suppresses microglial reactivity. Exp Neurol. 2015;273:114-25 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:200; 图 s4
Parchem R, Moore N, Fish J, Parchem J, Braga T, Shenoy A, et al. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep. 2015;12:760-73 pubmed 出版商
  • 免疫组化; 小鼠; 1:250
Wende C, Zoubaa S, Blak A, Echevarria D, Martinez S, Guillemot F, et al. Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis. PLoS ONE. 2015;10:e0127681 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Jarrar W, Vauti F, Arnold H, Holz A. Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system. Differentiation. 2015;89:70-6 pubmed 出版商
  • 免疫组化; 小鼠; 图 s5
Eisner A, Pazyra Murphy M, Durresi E, Zhou P, Zhao X, Chadwick E, et al. The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis. Dev Cell. 2015;33:22-35 pubmed 出版商
  • 免疫组化; 小鼠; 1:50; 图 s5
Arbeille E, Reynaud F, Sanyas I, Bozon M, Kindbeiter K, Causeret F, et al. Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 2015;6:6366 pubmed 出版商
  • 免疫组化; 小鼠; 图 s12
Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, et al. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014;5:5425 pubmed 出版商
  • 免疫组化; 小鼠; 图 3a
Goggolidou P, Stevens J, Agueci F, Keynton J, Wheway G, Grimes D, et al. ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development. 2014;141:3966-77 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:50; 图 6j
Zou M, Luo H, Xiang M. Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord. Dev Dyn. 2015;244:86-97 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:10; 图 3
Alfaro A, Roberts B, Kwong L, Bijlsma M, Roelink H. Ptch2 mediates the Shh response in Ptch1-/- cells. Development. 2014;141:3331-9 pubmed 出版商
  • 免疫组化; 小鼠; 1:10
Tiwari S, Dharmarajan S, Shivanna M, Otteson D, Belecky Adams T. Histone deacetylase expression patterns in developing murine optic nerve. BMC Dev Biol. 2014;14:30 pubmed 出版商
  • 免疫组化-自由浮动切片; common platanna; 1:500
Dominguez L, González A, Moreno N. Characterization of the hypothalamus of Xenopus laevis during development. II. The basal regions. J Comp Neurol. 2014;522:1102-31 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:25
Carrasco M, Delgado I, Soria B, Martin F, Rojas A. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest. 2012;122:3504-15 pubmed 出版商
Lager A, Corradin O, Cregg J, Elitt M, Shick H, Clayton B, et al. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Nat Commun. 2018;9:3708 pubmed 出版商
Lu T, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, et al. The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes. Cell Metab. 2018;27:1294-1308.e7 pubmed 出版商
Memon B, Karam M, Al Khawaga S, Abdelalim E. Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1. Stem Cell Res Ther. 2018;9:15 pubmed 出版商
Pusapati G, Kong J, Patel B, Krishnan A, Sagner A, Kinnebrew M, et al. CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Dev Cell. 2018;44:113-129.e8 pubmed 出版商
Wang C, Li J, Meng Q, Wang B. Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse. Dev Biol. 2017;430:156-165 pubmed 出版商
Varadarajan S, Butler S. Netrin1 establishes multiple boundaries for axon growth in the developing spinal cord. Dev Biol. 2017;430:177-187 pubmed 出版商
Hoelzl M, Heby Henricson K, Gerling M, Dias J, Kuiper R, Trünkle C, et al. Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model. Dev Biol. 2017;429:132-146 pubmed 出版商
Cai H, Liu A. Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord. Dev Biol. 2017;432:72-85 pubmed 出版商
Sabo J, Heine V, Silbereis J, Schirmer L, Levison S, Rowitch D. Olig1 is required for noggin-induced neonatal myelin repair. Ann Neurol. 2017;81:560-571 pubmed 出版商
Wang H, Matise M. Tcf7l2/Tcf4 Transcriptional Repressor Function Requires HDAC Activity in the Developing Vertebrate CNS. PLoS ONE. 2016;11:e0163267 pubmed 出版商
Md Moin A, Dhawan S, Shieh C, Butler P, Cory M, Butler A. Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes. J Clin Endocrinol Metab. 2016;101:3487-96 pubmed 出版商
Laumonnerie C, Tong Y, Alstermark H, Wilson S. Commissural axonal corridors instruct neuronal migration in the mouse spinal cord. Nat Commun. 2015;6:7028 pubmed 出版商
Caballero I, Manuel M, Molinek M, Quintana Urzainqui I, Mi D, Shimogori T, et al. Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer. Cell Rep. 2014;8:1405-18 pubmed 出版商
Pifarre P, Gutierrez Mecinas M, Prado J, Usero L, Roura Mir C, Giralt M, et al. Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions. Exp Neurol. 2014;251:58-71 pubmed 出版商
Achim K, Peltopuro P, Lahti L, Tsai H, Zachariah A, Astrand M, et al. The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors. Biol Open. 2013;2:990-7 pubmed 出版商
Tang M, Luo S, Tang V, Huang E. Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development. Neural Dev. 2013;8:8 pubmed 出版商
Kobayashi N, Homma S, Okada T, Masuda T, Sato N, Nishiyama K, et al. Elucidation of target muscle and detailed development of dorsal motor neurons in chick embryo spinal cord. J Comp Neurol. 2013;521:2987-3002 pubmed 出版商
Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales S, et al. The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell. 2013;152:210-23 pubmed 出版商
Joven A, Morona R, González A, Moreno N. Expression patterns of Pax6 and Pax7 in the adult brain of a urodele amphibian, Pleurodeles waltl. J Comp Neurol. 2013;521:2088-124 pubmed 出版商
Han L, Pan Y, Wang B. Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo. J Biol Chem. 2012;287:20483-9 pubmed 出版商
Rabe Bernhardt N, Memic F, Gezelius H, Thiebes A, Vallstedt A, Kullander K. DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function. Dev Biol. 2012;366:279-89 pubmed 出版商
Najm F, Zaremba A, Caprariello A, Nayak S, Freundt E, Scacheri P, et al. Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells. Nat Methods. 2011;8:957-62 pubmed 出版商
Skaggs K, Martin D, Novitch B. Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling. Development. 2011;138:3199-211 pubmed 出版商
Honig G, Liou A, Berger M, German M, Tecott L. Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line. J Biomed Sci. 2010;17:82 pubmed 出版商
Peltopuro P, Kala K, Partanen J. Distinct requirements for Ascl1 in subpopulations of midbrain GABAergic neurons. Dev Biol. 2010;343:63-70 pubmed 出版商
Cameron D, Pennimpede T, Petkovich M. Tulp3 is a critical repressor of mouse hedgehog signaling. Dev Dyn. 2009;238:1140-9 pubmed 出版商
Talbott J, Loy D, Liu Y, Qiu M, Bunge M, Rao M, et al. Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. Exp Neurol. 2005;192:11-24 pubmed
Ju M, Aroca P, Luo J, Puelles L, Redies C. Molecular profiling indicates avian branchiomotor nuclei invade the hindbrain alar plate. Neuroscience. 2004;128:785-96 pubmed
Takebayashi H, Nabeshima Y, Yoshida S, Chisaka O, Ikenaka K, Nabeshima Y. The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr Biol. 2002;12:1157-63 pubmed
Takebayashi H, Ohtsuki T, Uchida T, Kawamoto S, Okubo K, Ikenaka K, et al. Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube. Mech Dev. 2002;113:169-74 pubmed
Soula C, Danesin C, Kan P, Grob M, Poncet C, Cochard P. Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism. Development. 2001;128:1369-79 pubmed
Ericson J, Rashbass P, Schedl A, Brenner Morton S, Kawakami A, van Heyningen V, et al. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell. 1997;90:169-80 pubmed
产品信息
内部号码 :
2440
名称 :
74.5A5
Depositor Name :
Jessell, T.M. / Brenner-Morton, S.
Depositor Institution :
HHMI/Columbia University
Date Deposited :
2/12/99
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
抗原 :
Nkx2.2转录因子
抗原物种 :
宿主物种 :
小鼠
抗体亚型 :
MIgG2b
Isotype for catalog (legacy) :
IgG2b, kappa light chain
Positive Tested Species Reactivity :
鸡, 人类, 小鼠, 大鼠
Species Tested (legacy) :
mice, rat, chick, human
Initial Publication Pubmed ID :
9230312
Collections :
Cell signaling,Human,Neurodevelopment,Transcription factors
搜索关键词 :
Jessell, Thomas M / Brenner-Morton, Susan, Nkx2.2 transcription factor, Chicken, MIgG2b, Mouse/Rat/Chicken/Human, NKX2-2, NK2 homeobox 2, AB_2314952 AB_531794, monoclonal
抗原分子量 :
Apparent: 28-30 kDa
基因 :
NKX2-2
Alternate Gene Name(s) :
NK2同源异形盒2
UniProt数据库编号 :
Q9YHB7
抗体登记处号码 :
AB_2314952 AB_531794
免疫原 :
Nkx2.2-谷胱甘肽S-转移酶融合蛋白在大肠杆菌中表达
克隆性 :
单克隆
Myeloma Strain :
NS-1
表位定位 :
No
Recommended Applications :
FFPE, 免疫荧光, 免疫组化, 免疫印迹
免疫组化PubMed IDs :
12121626 21750031 23504940 11262237 27668865 29669275 31412250
免疫荧光PubMed IDs :
11960707 15464286 15698615 19334287 22521513 22549777 23332756 24211383 28253550 28800946 25960414 27110779 30311912
免疫印迹PubMed IDs :
23224769 15464286
FFPE PubMed IDs :
12121626 20417196
DSHB增长培养基 :
Iscove's
References (legacy) :
Cell 90, 169-180.; Curr. Biol. 12, 1157-1163.; Mech. Dev. 113, 169-174.; Neuroscience 128, 785-796.; Exp. Neurol. 192, 11-24.; Nat. Biotechnol. 24 (11), 1392-1401.; Dev. Dyn. 238, 1140-1149.; Dev. Biol. 343, 63-70.; Dev. Biol. 366, 279-289.; J. Biol. Chem. 287(24), 20483-20489.; Cell 152, 210-223.; J. Comp. Neurol. 521, 2088-2124.; Exp. Neurol. 251, 58-71.
公司信息
Developmental Studies Hybridoma Bank
University of Iowa
dshb@uiowa.edu
http://dshb.biology.uiowa.edu
公司总部: 美国
Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构,为生命科学研究领域及诊断领域,提供高质量的抗体等产品。