产品简要
公司名称 :
Developmental Studies Hybridoma Bank
产品类型 :
抗体
产品名称 :
Notch, intracellular domain
目录 :
C17.9C6
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
C17.9C6
反应物种 :
黑腹果蝇
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
文章摘录数: 53
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 黑腹果蝇; 1:50; 图 4d
Jörg D, Caygill E, Hakes A, Contreras E, Brand A, Simons B. The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism. elife. 2019;8: pubmed 出版商
  • 免疫组化; 黑腹果蝇; 1:1000; 图 1e
Loubiere V, Delest A, Thomas A, Bonev B, Schuettengruber B, Sati S, et al. Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development. Nat Genet. 2016;48:1436-1442 pubmed 出版商
  • 免疫印迹; 黑腹果蝇; 1:500; 图 2d
Erdmann I, Marter K, Kobler O, Niehues S, Abele J, Müller A, et al. Cell-selective labelling of proteomes in Drosophila melanogaster. Nat Commun. 2015;6:7521 pubmed 出版商
Zhao S, Wu C, Gao Z, Li X, Guo Z, Wang Z. Notch signaling governs the expression of glypican Dally to define the stem cell niche. Biol Open. 2020;9: pubmed 出版商
Paddibhatla I, Gautam D, Mishra R. SETDB1 modulates the differentiation of both the crystal cells and the lamellocytes in Drosophila. Dev Biol. 2019;456:74-85 pubmed 出版商
Fic W, Faria C, St Johnston D. IMP regulates Kuzbanian to control the timing of Notch signalling in Drosophila follicle cells. Development. 2019;146: pubmed 出版商
Li Y, Liu T, Zhang J. The ATPase TER94 regulates Notch signaling during Drosophila wing development. Biol Open. 2019;8: pubmed 出版商
Cara F, Bülow M, Simmonds A, Rachubinski R. Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy. Mol Biol Cell. 2018;29:2766-2783 pubmed 出版商
Wissel S, Harzer H, Bonnay F, Burkard T, Neumüller R, Knoblich J. Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop. J Cell Biol. 2018;217:3285-3300 pubmed 出版商
Del Bel L, Griffiths N, Wilk R, Wei H, Blagoveshchenskaya A, Burgess J, et al. The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye. Development. 2018;145: pubmed 出版商
Gomez Lamarca M, Falo Sanjuan J, Stojnic R, Abdul Rehman S, Muresan L, Jones M, et al. Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics. Dev Cell. 2018;44:611-623.e7 pubmed 出版商
Wang Z, Lyu J, Wang F, Miao C, Nan Z, Zhang J, et al. The histone deacetylase HDAC1 positively regulates Notch signaling during Drosophila wing development. Biol Open. 2018;7: pubmed 出版商
Ando T, Fujiwara H, Kojima T. The pivotal role of aristaless in development and evolution of diverse antennal morphologies in moths and butterflies. BMC Evol Biol. 2018;18:8 pubmed 出版商
Kannan R, Cox E, Wang L, Kuzina I, Gu Q, Giniger E. Tyrosine phosphorylation and proteolytic cleavage of Notch are required for non-canonical Notch/Abl signaling in Drosophila axon guidance. Development. 2018;145: pubmed 出版商
Shukla J, Deshpande G, Shashidhara L. Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster. Development. 2017;144:905-915 pubmed 出版商
Tognon E, Kobia F, Busi I, Fumagalli A, De Masi F, Vaccari T. Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster. Autophagy. 2016;12:499-514 pubmed 出版商
Reimels T, Pfleger C. Drosophila Rabex-5 restricts Notch activity in hematopoietic cells and maintains hematopoietic homeostasis. J Cell Sci. 2015;128:4512-25 pubmed 出版商
Troost T, Schneider M, Klein T. A re-examination of the selection of the sensory organ precursor of the bristle sensilla of Drosophila melanogaster. PLoS Genet. 2015;11:e1004911 pubmed 出版商
Morelli E, Ginefra P, Mastrodonato V, Beznoussenko G, Rusten T, Bilder D, et al. Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila. Autophagy. 2014;10:2251-68 pubmed 出版商
Couturier L, Trylinski M, Mazouni K, Darnet L, Schweisguth F. A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo. J Cell Biol. 2014;207:351-63 pubmed 出版商
Ignesti M, Barraco M, Nallamothu G, Woolworth J, Duchi S, Gargiulo G, et al. Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23. BMC Biol. 2014;12:12 pubmed 出版商
Scafidi J, Hammond T, Scafidi S, Ritter J, Jablonska B, Roncal M, et al. Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature. 2014;506:230-4 pubmed 出版商
Angulo Rojo C, Manning Cela R, Aguirre A, Ortega A, Lopez Bayghen E. Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA. ASN Neuro. 2013;5:e00130 pubmed 出版商
Schaaf C, Misulovin Z, Gause M, Koenig A, Dorsett D. The Drosophila enhancer of split gene complex: architecture and coordinate regulation by notch, cohesin, and polycomb group proteins. G3 (Bethesda). 2013;3:1785-94 pubmed 出版商
Sachan N, Mishra A, Mutsuddi M, Mukherjee A. The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation. PLoS ONE. 2013;8:e68247 pubmed 出版商
Whiteman P, de Madrid B, Taylor P, Li D, Heslop R, Viticheep N, et al. Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor. J Biol Chem. 2013;288:7305-12 pubmed 出版商
Gómez J, Wang Y, Riechmann V. Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis. J Cell Biol. 2012;199:1131-43 pubmed 出版商
Kulkarni V, Khadilkar R, Magadi S, Srivathsa M, Inamdar M. Asrij maintains the stem cell niche and controls differentiation during Drosophila lymph gland hematopoiesis. PLoS ONE. 2011;6:e27667 pubmed 出版商
Tajiri R, Misaki K, Yonemura S, Hayashi S. Joint morphology in the insect leg: evolutionary history inferred from Notch loss-of-function phenotypes in Drosophila. Development. 2011;138:4621-6 pubmed 出版商
Djiane A, Shimizu H, Wilkin M, Mazleyrat S, Jennings M, Avis J, et al. Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue. J Cell Biol. 2011;192:189-200 pubmed 出版商
Boyles R, Lantz K, Poertner S, Georges S, Andres A. Presenilin controls CBP levels in the adult Drosophila central nervous system. PLoS ONE. 2010;5:e14332 pubmed 出版商
Quijano J, Stinchfield M, Zerlanko B, Gibbens Y, Takaesu N, Hyman Walsh C, et al. The Sno oncogene antagonizes Wingless signaling during wing development in Drosophila. PLoS ONE. 2010;5:e11619 pubmed 出版商
Benhra N, Vignaux F, Dussert A, Schweisguth F, Le Borgne R. Neuralized promotes basal to apical transcytosis of delta in epithelial cells. Mol Biol Cell. 2010;21:2078-86 pubmed 出版商
Genevet A, Wehr M, Brain R, Thompson B, Tapon N. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell. 2010;18:300-8 pubmed 出版商
Matsuura A, Ito M, Sakaidani Y, Kondo T, Murakami K, Furukawa K, et al. O-linked N-acetylglucosamine is present on the extracellular domain of notch receptors. J Biol Chem. 2008;283:35486-95 pubmed 出版商
Bland C, Rand M. Methylmercury induces activation of Notch signaling. Neurotoxicology. 2006;27:982-91 pubmed
Mukherjee A, Veraksa A, Bauer A, Rosse C, Camonis J, Artavanis Tsakonas S. Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol. 2005;7:1191-201 pubmed
Kamimura K, Rhodes J, Ueda R, McNeely M, Shukla D, Kimata K, et al. Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase. J Cell Biol. 2004;166:1069-79 pubmed
Rawlins E, Lovegrove B, Jarman A. Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta. Development. 2003;130:6475-84 pubmed
Reed R. Evidence for Notch-mediated lateral inhibition in organizing butterfly wing scales. Dev Genes Evol. 2004;214:43-6 pubmed
Hu Y, Fortini M. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol. 2003;161:685-90 pubmed
Okajima T, Irvine K. Regulation of notch signaling by o-linked fucose. Cell. 2002;111:893-904 pubmed
Goto S, Taniguchi M, Muraoka M, Toyoda H, Sado Y, Kawakita M, et al. UDP-sugar transporter implicated in glycosylation and processing of Notch. Nat Cell Biol. 2001;3:816-22 pubmed
Lawrence N, Klein T, Brennan K, Martinez Arias A. Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila. Development. 2000;127:3185-95 pubmed
Parks A, Klueg K, Stout J, Muskavitch M. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development. 2000;127:1373-85 pubmed
Rand M, Grimm L, Artavanis Tsakonas S, Patriub V, Blacklow S, Sklar J, et al. Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol. 2000;20:1825-35 pubmed
Ye Y, Fortini M. Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. J Cell Biol. 1999;146:1351-64 pubmed
Ye Y, Lukinova N, Fortini M. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature. 1999;398:525-9 pubmed
Lecourtois M, Schweisguth F. Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos. Curr Biol. 1998;8:771-4 pubmed
Blahovec J. Stress relaxation in cherry fruit. Biorheology. 1996;33:451-62 pubmed
Fehon R, Kooh P, Rebay I, Regan C, Xu T, Muskavitch M, et al. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell. 1990;61:523-34 pubmed
Fehon R, Johansen K, Rebay I, Artavanis Tsakonas S. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol. 1991;113:657-69 pubmed
Xu T, Caron L, Fehon R, Artavanis Tsakonas S. The involvement of the Notch locus in Drosophila oogenesis. Development. 1992;115:913-22 pubmed
产品信息
内部号码 :
270
名称 :
C17.9C6
Depositor Name :
Artavanis-Tsakonas, S.
Depositor Institution :
Harvard Medical School
Date Deposited :
5/2/00
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
抗原 :
Notch, intracellular domain
抗原物种 :
果蝇
宿主物种 :
小鼠
抗体亚型 :
MIgG1, kappa light chain
Isotype for catalog (legacy) :
IgG1, kappa light chain
Positive Tested Species Reactivity :
果蝇
Species Tested (legacy) :
果蝇
Initial Publication Pubmed ID :
2185893
Collections :
Cardiac development,Cell adhesion,Cell markers,Cell signaling,Drosophila antigens,Neurodevelopment,Skeletal muscle,Transcription factors
搜索关键词 :
Artavanis-Tsakonas, S., Notch, intracellular domain, Drosophila, MIgG1, kappa light chain, Drosophila, N, CG3936, Notch, NECD, NICD, AB_528410, Monoclonal, Drosophila antigens/Cell markers/Transcription factors/Neurodevelopment/Cell signaling/Cardiac development/Cell adhesion/Skeletal muscle, Immunohistochemistry/Immunofluorescence/Western Blot/Immunoprecipitation
抗原分子量 :
Predicted: 289 kDa; Apparent: 300 kDa and C-terminal fragments of 120 kDa and lower MW, resulting from proteolysis.
基因 :
N
Alternate Gene Name(s) :
CG3936, Notch, NECD, NICD
UniProt数据库编号 :
P07207
抗体登记处号码 :
AB_528410
免疫原 :
Recombinant fusion protein containing aa 1791-2504 of the intracellular domain of Notch.
免疫原序列 :
Partial protein
克隆性 :
单克隆
Myeloma Strain :
Ag8
表位定位 :
Yes
Epitope Location or Sequence :
intracellular domain, aa 1791-2504.
表位定位Pubmed登录号 :
2185893
Recommended Applications :
免疫荧光, 免疫组化, 免疫沉淀, 免疫印迹
Immunoblotting (legacy) :
Excellent
免疫组化PubMed IDs :
1451667 10704384 31422102
免疫荧光PubMed IDs :
11533661 12526814 20410139 10206647 14618402 1451667 2016340 16284625 10704384 10669757 10862754 14627723 24286475 9093440
免疫印迹PubMed IDs :
2185893 11533661 10206647 9651681 16284625 18948267 10669757 10491396 16757030 24286475
免疫沉淀PubMed IDs :
16284625 10669757
其他信息 :
The Neurogenic locus Notch protein functions as a transmembrane receptor for membrane-bound ligands Delta and Serrate to regulate neurodevelopment. Upon ligand activation, the intracellular domain (NICD) is released from the cell membrane, and forms a transcriptional activator complex with the Suppressor of hairless protein.
DSHB增长培养基 :
RPMI
References (legacy) :
Cell 61, 523-534.; Nature Cell Biol. 3(9), 816-822.; Cell 111, 893-904.; Mole. Biol. Cell 21, 2078-2086.
公司信息
Developmental Studies Hybridoma Bank
University of Iowa
dshb@uiowa.edu
http://dshb.biology.uiowa.edu
公司总部: 美国
Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构,为生命科学研究领域及诊断领域,提供高质量的抗体等产品。