产品简要
公司名称 :
Developmental Studies Hybridoma Bank
产品类型 :
抗体
产品名称 :
Notch, intracellular domain
目录 :
C17.9C6
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
C17.9C6
反应物种 :
黑腹果蝇
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
文章摘录数: 53
出版应用/物种/样本/稀释 | 参考文献 |
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Bland C, Rand M. Methylmercury induces activation of Notch signaling. Neurotoxicology. 2006;27:982-91 pubmed
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Mukherjee A, Veraksa A, Bauer A, Rosse C, Camonis J, Artavanis Tsakonas S. Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol. 2005;7:1191-201 pubmed
| |
Kamimura K, Rhodes J, Ueda R, McNeely M, Shukla D, Kimata K, et al. Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase. J Cell Biol. 2004;166:1069-79 pubmed
| |
Rawlins E, Lovegrove B, Jarman A. Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta. Development. 2003;130:6475-84 pubmed
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Reed R. Evidence for Notch-mediated lateral inhibition in organizing butterfly wing scales. Dev Genes Evol. 2004;214:43-6 pubmed
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Hu Y, Fortini M. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol. 2003;161:685-90 pubmed
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Okajima T, Irvine K. Regulation of notch signaling by o-linked fucose. Cell. 2002;111:893-904 pubmed
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Goto S, Taniguchi M, Muraoka M, Toyoda H, Sado Y, Kawakita M, et al. UDP-sugar transporter implicated in glycosylation and processing of Notch. Nat Cell Biol. 2001;3:816-22 pubmed
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Lawrence N, Klein T, Brennan K, Martinez Arias A. Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila. Development. 2000;127:3185-95 pubmed
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Parks A, Klueg K, Stout J, Muskavitch M. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development. 2000;127:1373-85 pubmed
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Rand M, Grimm L, Artavanis Tsakonas S, Patriub V, Blacklow S, Sklar J, et al. Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol. 2000;20:1825-35 pubmed
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Ye Y, Fortini M. Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. J Cell Biol. 1999;146:1351-64 pubmed
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Ye Y, Lukinova N, Fortini M. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature. 1999;398:525-9 pubmed
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Lecourtois M, Schweisguth F. Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos. Curr Biol. 1998;8:771-4 pubmed
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Blahovec J. Stress relaxation in cherry fruit. Biorheology. 1996;33:451-62 pubmed
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Fehon R, Kooh P, Rebay I, Regan C, Xu T, Muskavitch M, et al. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell. 1990;61:523-34 pubmed
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Fehon R, Johansen K, Rebay I, Artavanis Tsakonas S. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol. 1991;113:657-69 pubmed
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Xu T, Caron L, Fehon R, Artavanis Tsakonas S. The involvement of the Notch locus in Drosophila oogenesis. Development. 1992;115:913-22 pubmed
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产品信息
内部号码 :
270
名称 :
C17.9C6
Depositor Name :
Artavanis-Tsakonas, S.
Depositor Institution :
Harvard Medical School
Date Deposited :
5/2/00
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
抗原 :
Notch, intracellular domain
抗原物种 :
果蝇
宿主物种 :
小鼠
抗体亚型 :
MIgG1, kappa light chain
Isotype for catalog (legacy) :
IgG1, kappa light chain
Positive Tested Species Reactivity :
果蝇
Species Tested (legacy) :
果蝇
Initial Publication Pubmed ID :
2185893
Collections :
Cardiac development,Cell adhesion,Cell markers,Cell signaling,Drosophila antigens,Neurodevelopment,Skeletal muscle,Transcription factors
搜索关键词 :
Artavanis-Tsakonas, S., Notch, intracellular domain, Drosophila, MIgG1, kappa light chain, Drosophila, N, CG3936, Notch, NECD, NICD, AB_528410, Monoclonal, Drosophila antigens/Cell markers/Transcription factors/Neurodevelopment/Cell signaling/Cardiac development/Cell adhesion/Skeletal muscle, Immunohistochemistry/Immunofluorescence/Western Blot/Immunoprecipitation
抗原分子量 :
Predicted: 289 kDa; Apparent: 300 kDa and C-terminal fragments of 120 kDa and lower MW, resulting from proteolysis.
基因 :
N
Alternate Gene Name(s) :
CG3936, Notch, NECD, NICD
UniProt数据库编号 :
P07207
抗体登记处号码 :
AB_528410
免疫原 :
Recombinant fusion protein containing aa 1791-2504 of the intracellular domain of Notch.
免疫原序列 :
Partial protein
克隆性 :
单克隆
Myeloma Strain :
Ag8
表位定位 :
Yes
Epitope Location or Sequence :
intracellular domain, aa 1791-2504.
表位定位Pubmed登录号 :
2185893
Recommended Applications :
免疫荧光, 免疫组化, 免疫沉淀, 免疫印迹
Immunoblotting (legacy) :
Excellent
免疫组化PubMed IDs :
1451667 10704384 31422102
免疫荧光PubMed IDs :
11533661 12526814 20410139 10206647 14618402 1451667 2016340 16284625 10704384 10669757 10862754 14627723 24286475 9093440
免疫印迹PubMed IDs :
2185893 11533661 10206647 9651681 16284625 18948267 10669757 10491396 16757030 24286475
免疫沉淀PubMed IDs :
16284625 10669757
其他信息 :
The Neurogenic locus Notch protein functions as a transmembrane receptor for membrane-bound ligands Delta and Serrate to regulate neurodevelopment. Upon ligand activation, the intracellular domain (NICD) is released from the cell membrane, and forms a transcriptional activator complex with the Suppressor of hairless protein.
DSHB增长培养基 :
RPMI
References (legacy) :
Cell 61, 523-534.; Nature Cell Biol. 3(9), 816-822.; Cell 111, 893-904.; Mole. Biol. Cell 21, 2078-2086.
公司信息
Developmental Studies Hybridoma Bank
Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构,为生命科学研究领域及诊断领域,提供高质量的抗体等产品。
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