产品简要
公司名称 :
Developmental Studies Hybridoma Bank
产品类型 :
抗体
产品名称 :
Notch2 intracellular domain (human)
目录 :
C651.6DbHN
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
C651.6DbHN
反应物种 :
人类, 小鼠, 狗
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
文章摘录数: 29
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 s4a
Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny Geier G, et al. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018;9:3839 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2e
Hwang I, Boularan C, Harrison K, Kehrl J. Gαi Signaling Promotes Marginal Zone B Cell Development by Enabling Transitional B Cell ADAM10 Expression. Front Immunol. 2018;9:687 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Fujiwara T, Zhou J, Ye S, Zhao H. RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell Death Dis. 2016;7:e2300 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 5
  • 免疫印迹; 人类; 1:1000; 图 2
Dhar S, Kumar A, Zhang L, Rimando A, Lage J, Lewin J, et al. Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer. Oncotarget. 2016;7:18469-84 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:200
DeFalco T, Saraswathula A, Briot A, Iruela Arispe M, Capel B. Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. Biol Reprod. 2013;88:91 pubmed 出版商
Azimi M, Le T, Brown N. Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation. 2018;102:40-52 pubmed 出版商
Yu J, Zanotti S, Walia B, JELLISON E, Sanjay A, Canalis E. The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone. Am J Pathol. 2018;188:149-159 pubmed 出版商
Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy. Hepatology. 2018;67:972-988 pubmed 出版商
Fortini F, Vieceli Dalla Sega F, Caliceti C, Aquila G, Pannella M, Pannuti A, et al. Estrogen receptor β-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis. J Biol Chem. 2017;292:18178-18191 pubmed 出版商
Zhang S, Chung W, Xu K. Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. Oncogene. 2016;35:2485-95 pubmed 出版商
Bauer L, Takacs A, Slotta Huspenina J, Langer R, Becker K, Novotny A, et al. Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study. Front Oncol. 2015;5:94 pubmed 出版商
Zhou J, Fujiwara T, Ye S, Li X, Zhao H. Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2. Calcif Tissue Int. 2015;96:465-75 pubmed 出版商
Baumgart A, Mazur P, Anton M, Rudelius M, Schwamborn K, Feuchtinger A, et al. Opposing role of Notch1 and Notch2 in a Kras(G12D)-driven murine non-small cell lung cancer model. Oncogene. 2015;34:578-88 pubmed 出版商
Simonetti G, Carette A, Silva K, Wang H, De Silva N, Heise N, et al. IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity. J Exp Med. 2013;210:2887-902 pubmed 出版商
Caliceti C, Aquila G, Pannella M, Morelli M, Fortini C, Pinton P, et al. 17β-estradiol enhances signalling mediated by VEGF-A-delta-like ligand 4-notch1 axis in human endothelial cells. PLoS ONE. 2013;8:e71440 pubmed 出版商
Bauer L, Langer R, Becker K, Hapfelmeier A, Ott K, Novotny A, et al. Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and ?-catenin gene signature predicts survival. PLoS ONE. 2012;7:e44566 pubmed 出版商
Tu X, Chen J, Lim J, Karner C, Lee S, Heisig J, et al. Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet. 2012;8:e1002577 pubmed 出版商
Mazur P, Riener M, Jochum W, Kristiansen G, Weber A, Schmid R, et al. Expression and clinicopathological significance of notch signaling and cell-fate genes in biliary tract cancer. Am J Gastroenterol. 2012;107:126-35 pubmed 出版商
Zeuner A, Francescangeli F, Signore M, Venneri M, Pedini F, Felli N, et al. The Notch2-Jagged1 interaction mediates stem cell factor signaling in erythropoiesis. Cell Death Differ. 2011;18:371-80 pubmed 出版商
Watanabe K, Nagaoka T, Lee J, Bianco C, Gonzales M, Castro N, et al. Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1. J Cell Biol. 2009;187:343-53 pubmed 出版商
Ellsworth B, Butts D, Camper S. Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice. Dev Biol. 2008;313:118-29 pubmed
Brinkmeier M, Potok M, Davis S, Camper S. TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol. 2007;311:396-407 pubmed
Raetzman L, Cai J, Camper S. Hes1 is required for pituitary growth and melanotrope specification. Dev Biol. 2007;304:455-66 pubmed
Noggle S, Weiler D, Condie B. Notch signaling is inactive but inducible in human embryonic stem cells. Stem Cells. 2006;24:1646-53 pubmed
Tanimizu N, Miyajima A. Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. J Cell Sci. 2004;117:3165-74 pubmed
Raetzman L, Ross S, Cook S, Dunwoodie S, Camper S, Thomas P. Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression. Dev Biol. 2004;265:329-40 pubmed
Nefedova Y, Cheng P, Alsina M, Dalton W, Gabrilovich D. Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood. 2004;103:3503-10 pubmed
Blaumueller C, Qi H, Zagouras P, Artavanis Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell. 1997;90:281-91 pubmed
Zagouras P, Stifani S, Blaumueller C, Carcangiu M, Artavanis Tsakonas S. Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci U S A. 1995;92:6414-8 pubmed
产品信息
内部号码 :
276
名称 :
C651.6DbHN
Depositor Name :
Artavanis-Tsakonas, S.
Depositor Institution :
Harvard Medical School
Date Deposited :
5/2/00
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
抗原 :
Notch2 intracellular domain (human)
抗原物种 :
人类
宿主物种 :
大鼠
抗体亚型 :
RIgG1, kappa light chain
Isotype for catalog (legacy) :
IgG1, kappa light chain
Positive Tested Species Reactivity :
狗, 人类, 小鼠
Species Tested (legacy) :
人类, 小鼠, 狗
Initial Publication Pubmed ID :
7604005
Depositor Notes (Special Instructions) :
Works well for Immunoprecipitation
Collections :
Cardiac development,Cell adhesion,Cell signaling,Human,Transcription factors
搜索关键词 :
Artavanis-Tsakonas, S., Notch2 intracellular domain (human), Human, RIgG1, kappa light chain, Human/mouse/canine, Neurogenic locus notch homolog protein 2, NOTCH2, hN2, N2ICD, AGS2, HJCYS, AB_528412, monoclonal, Cardiac development/Cell adhesion/Cell signaling/Human/Transcription factors, Immunohistochemistry/Immunofluorescence/Western Blot/Immunoprecipitation
抗原分子量 :
Apparent: 300 kDa processed to give a major intracellular product of 110 kDa
基因 :
NOTCH2
Alternate Gene Name(s) :
hN2;AGS2;HJCYS
UniProt数据库编号 :
Q04721
抗体登记处号码 :
AB_528412
Synonyms (Alternate Clone Names) :
6D, bhN6D
免疫原 :
Recombinant fusion protein GST-Notch2 intrcellular domain
免疫原序列 :
Partial protein
克隆性 :
单克隆
Myeloma Strain :
Ag8/ATCC CRL1580
表位定位 :
Yes
Epitope Location or Sequence :
intracellular domain
表位定位Pubmed登录号 :
7604005
Recommended Applications :
流式细胞仪, 免疫荧光, 免疫组化, 免疫沉淀, 免疫印迹
Immunoblotting (legacy) :
Excellent
免疫组化PubMed IDs :
7604005 24509876 26279302 21931375 15226394
免疫荧光PubMed IDs :
7604005 17919533 18037398 14732396 25712254
免疫印迹PubMed IDs :
7604005 9244302 23967210 14670925 24509876 16614005 26279302 20829885 31371452
流式细胞仪PubMed IDs :
20829885
DSHB增长培养基 :
RPMI
References (legacy) :
Proc. Natl. Acad. Sci. 92, 6414-6418.; Cell 90, 281-291.; Dev. Biol. 304, 455-466.; Dev. Biol. 311, 396-407.; Dev. Biol. 313, 118-129.; PLoS One 8(8): e71440. doi:10.1371/journal.pone.0071440.
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
公司信息
Developmental Studies Hybridoma Bank
University of Iowa
dshb@uiowa.edu
http://dshb.biology.uiowa.edu
公司总部: 美国
Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构，为生命科学研究领域及诊断领域，提供高质量的抗体等产品。