产品简要
公司名称 :
Developmental Studies Hybridoma Bank
产品类型 :
抗体
产品名称 :
CD11b (Integrin alpha-M, Mac-1 alpha chain), murine
目录 :
M1/70.15.11.5.2
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
M1/70.15.11.5.2
反应物种 :
人类, 小鼠
应用 :
免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
文章摘录数: 29
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 图 s2d
Huang H, Liu Y, Wang L, Li W. Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. PLoS ONE. 2017;12:e0173716 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 2k
Zhu J, Cifuentes H, Reynolds J, Lamba D. Immunosuppression via Loss of IL2rγ Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina. Cell Stem Cell. 2017;20:374-384.e5 pubmed 出版商
  • 免疫组化; 小鼠; 1:10; 图 3
Gu X, Liu X, Chen Y, Zhao Y, Xu M, Han X, et al. Involvement of NADPH oxidases in alkali burn-induced corneal injury. Int J Mol Med. 2016;38:75-82 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:50; 图 s7
Dooves S, Bugiani M, Postma N, Polder E, Land N, Horan S, et al. Astrocytes are central in the pathomechanisms of vanishing white matter. J Clin Invest. 2016;126:1512-24 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1
Paone C, Rodrigues N, Ittner E, Santos C, Buntru A, Hauck C. The Tyrosine Kinase Pyk2 Contributes to Complement-Mediated Phagocytosis in Murine Macrophages. J Innate Immun. 2016;8:437-51 pubmed 出版商
  • 免疫组化; 小鼠; 1:5
Astafurov K, Elhawy E, Ren L, Dong C, Igboin C, Hyman L, et al. Oral microbiome link to neurodegeneration in glaucoma. PLoS ONE. 2014;9:e104416 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠
Labarge S, McDonald M, Smith Powell L, Auwerx J, Huss J. Estrogen-related receptor-? (ERR?) deficiency in skeletal muscle impairs regeneration in response to injury. FASEB J. 2014;28:1082-97 pubmed 出版商
Kulkarni U, Karsten C, Kohler T, Hammerschmidt S, Bommert K, Tiburzy B, et al. IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration. J Allergy Clin Immunol. 2016;137:1487-1497.e6 pubmed 出版商
Winsauer C, Prepens S, Schlienz D, Nedospasov S, Kruglov A. Novel mouse model to study T cell-dependent IgA induction in vivo. J Immunol Methods. 2015;421:54-60 pubmed 出版商
Zehentmeier S, Roth K, Cseresnyes Z, Sercan O, Horn K, Niesner R, et al. Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells. Eur J Immunol. 2014;44:2306-17 pubmed 出版商
Dai S, Rajaram M, Curry H, Leander R, Schlesinger L. Fine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensis. PLoS Pathog. 2013;9:e1003114 pubmed 出版商
Shibasaki K, Suzuki M, Mizuno A, Tominaga M. Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4. J Neurosci. 2007;27:1566-75 pubmed
Hagihara H, Hara M, Tsunekawa K, Nakagawa Y, Sawada M, Nakano K. Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. Brain Res Mol Brain Res. 2005;139:258-66 pubmed
Rotshenker S. Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease. J Mol Neurosci. 2003;21:65-72 pubmed
Brickson S, Ji L, Schell K, Olabisi R, St Pierre Schneider B, Best T. M1/70 attenuates blood-borne neutrophil oxidants, activation, and myofiber damage following stretch injury. J Appl Physiol (1985). 2003;95:969-76 pubmed
Reichert F, Rotshenker S. Complement-receptor-3 and scavenger-receptor-AI/II mediated myelin phagocytosis in microglia and macrophages. Neurobiol Dis. 2003;12:65-72 pubmed
Reichert F, Slobodov U, Makranz C, Rotshenker S. Modulation (inhibition and augmentation) of complement receptor-3-mediated myelin phagocytosis. Neurobiol Dis. 2001;8:504-12 pubmed
Welt F, Edelman E, Simon D, Rogers C. Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries. Arterioscler Thromb Vasc Biol. 2000;20:2553-8 pubmed
Driessens M, van Hulten P, Zuurbier A, La Riviere G, Roos E. Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct. J Leukoc Biol. 1996;60:758-65 pubmed
Guy R, Belosevic M. Comparison of receptors required for entry of Leishmania major amastigotes into macrophages. Infect Immun. 1993;61:1553-8 pubmed
Fan S, Edgington T. Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes. J Immunol. 1993;150:2972-80 pubmed
Ault K, Springer T. Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells. J Immunol. 1981;126:359-64 pubmed
Beller D, Springer T, Schreiber R. Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor. J Exp Med. 1982;156:1000-9 pubmed
Holmberg L, Springer T, Ault K. Natural killer activity in the peritoneal exudates of mice infected with Listeria monocytogenes: characterization of the natural killer cells by using a monoclonal rat anti-murine macrophage antibody (M1/70). J Immunol. 1981;127:1792-9 pubmed
Kürzinger K, Springer T. Purification and structural characterization of LFA-1, a lymphocyte function-associated antigen, and Mac-1, a related macrophage differentiation antigen associated with the type three complement receptor. J Biol Chem. 1982;257:12412-8 pubmed
Sanchez Madrid F, Simon P, Thompson S, Springer T. Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med. 1983;158:586-602 pubmed
Anderson D, Miller L, Schmalstieg F, Rothlein R, Springer T. Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies. J Immunol. 1986;137:15-27 pubmed
Krauss J, Mayo Bond L, Rogers C, Weber K, Todd R, Wilson J. An in vivo animal model of gene therapy for leukocyte adhesion deficiency. J Clin Invest. 1991;88:1412-7 pubmed
Sawada M, Wilkinson J, MacAdoo D, Coggeshall R. The identification of two inhibitory cells in each segmental ganglion of the leech and studies on the ionic mechanism of the inhibitory junctional potentials produced by these cells. J Neurobiol. 1976;7:435-45 pubmed
产品信息
内部号码 :
2296
名称 :
M1/70.15.11.5.2
Depositor Name :
Springer, T.A.
Depositor Institution :
Center for Blood Research, Boston
Date Deposited :
4/4/89
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
抗原 :
CD11b (Integrin alpha-M, Mac-1 alpha chain), murine
抗原物种 :
小鼠
宿主物种 :
大鼠
抗体亚型 :
RIgG2b
Isotype for catalog (legacy) :
IgG2b
Positive Tested Species Reactivity :
人类, 小鼠
Species Tested (legacy) :
cross reacts with human antigen
Initial Publication Pubmed ID :
81133
Depositor Notes (Special Instructions) :
Blocks iC3B rosetting. Binds to granulocytes, monocytes, macrophages, hairy cell leukemia cells, CD5+ human B cells. Doesn't appear to work for western blotting.
Collections :
CD antigens,Cell adhesion,Cell markers,Cell signaling,Extracellular matrix proteins,Human,Stem cell
搜索关键词 :
Springer, T.A., CD11b (Integrin alpha-M, Mac-1 alpha chain), murine, Mouse, RIgG2b, Human/Mouse, Itgam, MAC-1, MO1A, CR3, AB_2234066, monoclonal, Human/Extracellular matrix proteins/Cluster Determinant antigens/Cell signaling/Cell adhesion/Cell markers/Stem cell, Immunohistochemistry/Immunofluorescence/Immunoprecipitation/Function Blocking/FACS
抗原分子量 :
Predicted: 128 kDa; Apparent: 170 kDa
基因 :
Itgam
Alternate Gene Name(s) :
MAC-1, MO1A, CR3
UniProt数据库编号 :
P05555
抗体登记处号码 :
AB_2234066
Synonyms (Alternate Clone Names) :
M1/70
免疫原 :
脾脏细胞来自B10老鼠
免疫原序列 :
全长蛋白
克隆性 :
单克隆
Myeloma Strain :
NS1
表位定位 :
No
Recommended Applications :
FACS,Function Blocking,Immunofluorescence,Immunohistochemistry,Immunoprecipitation
Immunoblotting (legacy) :
No
免疫组化PubMed IDs :
185332
免疫荧光PubMed IDs :
16023256 23359218
免疫沉淀PubMed IDs :
81133 89034 6193226 185332 8975879 6749860
Function Blocking Pubmed IDs :
12730143 6193226 12609490 8095957 11442357 8454363 14500997 11116052 3519773 7153706
流式细胞仪PubMed IDs :
89034 6795262 12730143 7451976 25790905 26653800 24777940 185332 6749860 1680882
PubMed IDs :
17301165
其他信息 :
Mac-1 is a macrophage differenciation antigen and a marker for microglia.
DSHB增长培养基 :
RPMI
References (legacy) :
Eur. J. Immunol. 8, 539-551.; Eur. J. Immunol. 9, 301-306.; J. Neurosci. 27(7), 1566-1575.
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
公司信息
Developmental Studies Hybridoma Bank
University of Iowa
dshb@uiowa.edu
http://dshb.biology.uiowa.edu
公司总部: 美国
Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构，为生命科学研究领域及诊断领域，提供高质量的抗体等产品。