产品简要
公司名称 :
Developmental Studies Hybridoma Bank
产品类型 :
抗体
产品名称 :
CD18 (integrin beta-2; beta subunit of CD11a, b, c), human
目录 :
TS1/18.1。 2.11.4
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
TS1/18.1。 2.11.4
反应物种 :
人类
应用 :
免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
文章摘录数: 15
参考文献
Burns S, Hardy S, Buddle J, Yong K, Jones G, Thrasher A. Maturation of DC is associated with changes in motile characteristics and adherence. Cell Motil Cytoskeleton. 2004;57:118-32 pubmed
Beals C, Edwards A, Gottschalk R, Kuijpers T, Staunton D. CD18 activation epitopes induced by leukocyte activation. J Immunol. 2001;167:6113-22 pubmed
Lu C, Ferzly M, Takagi J, Springer T. Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation. J Immunol. 2001;166:5629-37 pubmed
Cywes C, Godenir N, Hoppe H, Scholle R, Steyn L, Kirsch R, et al. Nonopsonic binding of Mycobacterium tuberculosis to human complement receptor type 3 expressed in Chinese hamster ovary cells. Infect Immun. 1996;64:5373-83 pubmed
Petruzzelli L, Maduzia L, Springer T. Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18. J Immunol. 1995;155:854-66 pubmed
McGuire S, Bajt M. Distinct ligand binding sites in the I domain of integrin alpha M beta 2 that differentially affect a divalent cation-dependent conformation. J Biol Chem. 1995;270:25866-71 pubmed
Sanchez Madrid F, Krensky A, Ware C, Robbins E, Strominger J, Burakoff S, et al. Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A. 1982;79:7489-93 pubmed
Sanchez Madrid F, Nagy J, Robbins E, Simon P, Springer T. A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule. J Exp Med. 1983;158:1785-1803 pubmed
Fischer A, Durandy A, Sterkers G, Griscelli C. Role of the LFA-1 molecule in cellular interactions required for antibody production in humans. J Immunol. 1986;136:3198-203 pubmed
Van Epps D, Potter J, Vachula M, Smith C, Anderson D. Suppression of human lymphocyte chemotaxis and transendothelial migration by anti-LFA-1 antibody. J Immunol. 1989;143:3207-10 pubmed
Dustin M, Springer T. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature. 1989;341:619-24 pubmed
Takahashi S, Doss C, Levy S, Levy R. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. J Immunol. 1990;145:2207-13 pubmed
Yellin M, Lee J, Chess L, Lederman S. A human CD4- T cell leukemia subclone with contact-dependent helper function. J Immunol. 1991;147:3389-95 pubmed
Beekhuizen H, Corsèl van Tilburg A, Blokland I, Van Furth R. Characterization of the adherence of human monocytes to cytokine-stimulated human macrovascular endothelial cells. Immunology. 1991;74:661-9 pubmed
Ardman B, Sikorski M, Staunton D. CD43 interferes with T-lymphocyte adhesion. Proc Natl Acad Sci U S A. 1992;89:5001-5 pubmed
产品信息
内部号码 :
2314
名称 :
TS1/18.1。 2.11.4
Depositor Name :
Springer, T.A.
Depositor Institution :
Center for Blood Research
Date Deposited :
4/4/89
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
抗原 :
CD18 (integrin beta-2; beta subunit of CD11a, b, c), human
抗原物种 :
人类
宿主物种 :
小鼠
抗体亚型 :
MIgG1
Isotype for catalog (legacy) :
IgG1
Positive Tested Species Reactivity :
人类
Species Tested (legacy) :
does not cross react with mouse
Initial Publication Pubmed ID :
6984191
Depositor Notes (Special Instructions) :
Does not cross react with mouse. Binds to all leukocytes. Blocks CTL killing, ADCC killing of NK & granulocytes, homotypic B cell adhesion, gammaINF adhesion of monocytes, leukocyte-epithelial cell interactions. Doesn't appear to work for western blotting.
Collections :
CD antigens,Cell adhesion,Cell markers,Cell signaling,Human
搜索关键词 :
Springer, T.A., CD18 (integrin beta-2; beta subunit of CD11a, b, c), human, Human, MIgG1, Human, ITGB2, CD18, MFI7, LAD, LCAMB, LFA-1, MAC-1, AB_2128634, monoclonal, Human/Cell signaling/Cluster Determinant antigens/Cell adhesion/Cell markers, Immunofluorescence/Immunohistochemistry/Immunofluorescence/Function Blocking/Immunoprecipitation/FACS
抗原分子量 :
Predicted: 85 kDa; Apparent: 93 kDa
基因 :
ITGB2
Alternate Gene Name(s) :
CD18, MFI7, LAD, LCAMB, LFA-1, MAC-1
UniProt数据库编号 :
P05107
抗体登记处号码 :
AB_2128634
Synonyms (Alternate Clone Names) :
TS1/18
免疫原 :
Human HLA-DRCTL line cytolytic T-lymphocytes.
免疫原序列 :
全长蛋白
克隆性 :
单克隆
Myeloma Strain :
P3X63Ag8.6。 5.3
表位定位 :
No
Recommended Applications :
FACS,Function Blocking,Immunofluorescence,Immunohistochemistry,Immunoprecipitation
Immunoblotting (legacy) :
No
免疫荧光PubMed IDs :
3514755 11714770
免疫沉淀PubMed IDs :
6984191 8945590 7592772 7608563 6196430
Function Blocking Pubmed IDs :
6984191 8945590 14691951 2477710 3514755 2681413 2398277 1594606 11714770
流式细胞仪PubMed IDs :
6984191 11313403 2681413 7608563 6196430 1834738 11714770
PubMed IDs :
1723715
其他信息 :
CD18 is a general marker of leukocytes.
DSHB增长培养基 :
RPMI
References (legacy) :
PNAS 79, 7489-7493
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
公司信息
Developmental Studies Hybridoma Bank
University of Iowa
dshb@uiowa.edu
http://dshb.biology.uiowa.edu
公司总部: 美国
Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构，为生命科学研究领域及诊断领域，提供高质量的抗体等产品。