产品简要
公司名称 :
Developmental Studies Hybridoma Bank
产品类型 :
抗体
产品名称 :
CD11a(整合素甲L, LFA-1甲亚单位), 人类
目录 :
TS1/22.1。 1.13.3
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
TS1/22.1。 1.13.3
反应物种 :
人类
应用 :
免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪
文章摘录数: 17
参考文献
Godwin J, d Apice A, Cowan P. Characterization of pig intercellular adhesion molecule-2 and its interaction with human LFA-1. Am J Transplant. 2004;4:515-25 pubmed
Spaargaren M, Beuling E, Rurup M, Meijer H, Klok M, Middendorp S, et al. The B cell antigen receptor controls integrin activity through Btk and PLCgamma2. J Exp Med. 2003;198:1539-50 pubmed
Beals C, Edwards A, Gottschalk R, Kuijpers T, Staunton D. CD18 activation epitopes induced by leukocyte activation. J Immunol. 2001;167:6113-22 pubmed
Lu C, Ferzly M, Takagi J, Springer T. Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation. J Immunol. 2001;166:5629-37 pubmed
Huang C, Springer T. A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1). J Biol Chem. 1995;270:19008-16 pubmed
Petruzzelli L, Maduzia L, Springer T. Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18. J Immunol. 1995;155:854-66 pubmed
Sanchez Madrid F, Krensky A, Ware C, Robbins E, Strominger J, Burakoff S, et al. Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A. 1982;79:7489-93 pubmed
Sanchez Madrid F, Nagy J, Robbins E, Simon P, Springer T. A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule. J Exp Med. 1983;158:1785-1803 pubmed
Fischer A, Durandy A, Sterkers G, Griscelli C. Role of the LFA-1 molecule in cellular interactions required for antibody production in humans. J Immunol. 1986;136:3198-203 pubmed
Van Epps D, Potter J, Vachula M, Smith C, Anderson D. Suppression of human lymphocyte chemotaxis and transendothelial migration by anti-LFA-1 antibody. J Immunol. 1989;143:3207-10 pubmed
Dustin M, Springer T. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature. 1989;341:619-24 pubmed
Basson C, Knowles W, Bell L, Albelda S, Castronovo V, Liotta L, et al. Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events. J Cell Biol. 1990;110:789-801 pubmed
Takahashi S, Doss C, Levy S, Levy R. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. J Immunol. 1990;145:2207-13 pubmed
Denning S, Le P, Singer K, Haynes B. Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation. J Immunol. 1990;144:7-15 pubmed
Yellin M, Lee J, Chess L, Lederman S. A human CD4- T cell leukemia subclone with contact-dependent helper function. J Immunol. 1991;147:3389-95 pubmed
Beekhuizen H, Corsèl van Tilburg A, Blokland I, Van Furth R. Characterization of the adherence of human monocytes to cytokine-stimulated human macrovascular endothelial cells. Immunology. 1991;74:661-9 pubmed
Ardman B, Sikorski M, Staunton D. CD43 interferes with T-lymphocyte adhesion. Proc Natl Acad Sci U S A. 1992;89:5001-5 pubmed
产品信息
内部号码 :
2320
名称 :
TS1/22.1。 1.13.3
Depositor Name :
Springer, T.A.
Depositor Institution :
Center for Blood Research
Date Deposited :
4/4/89
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
抗原 :
CD11a(整合素甲L, LFA-1甲亚单位), 人类
抗原物种 :
人类
宿主物种 :
小鼠
抗体亚型 :
MIgG1
Isotype for catalog (legacy) :
IgG1
Positive Tested Species Reactivity :
人类
Initial Publication Pubmed ID :
6984191
Depositor Notes (Special Instructions) :
Blocks CTL killing, ADCC killing of NK & granulocytes, homotypic B cell adhesion, gammaINF adhesion of monocytes, leukocyte-epithelial cell interactions. Doesn't appear to work for western blotting. Binds to all leukocytes.
Collections :
CD antigens,Cell adhesion,Cell markers,Cell signaling,Human
搜索关键词 :
Springer, T.A., CD11a (Integrin alpha-L, LFA-1 alpha subunit), human, Human, MIgG1, Human, ITGAL, LFA-1, AB_528132, monoclonal, Human/Cell signaling/Cluster Determinant antigens/Cell adhesion/Cell markers, Immunohistochemistry/Immunofluorescence/Function Blocking/Immunoprecipitation/FACS
抗原分子量 :
Predicted: 129 kDa; Apparent: 180 kDa
基因 :
ITGAL
Alternate Gene Name(s) :
LFA-1
UniProt数据库编号 :
P20701
抗体登记处号码 :
AB_528132
Synonyms (Alternate Clone Names) :
TS1/22
免疫原 :
Human HLA-DRCTL line cytolytic T-lymphocytes.
免疫原序列 :
全长蛋白
克隆性 :
单克隆
Myeloma Strain :
P3X63Ag8.6。 5.3
表位定位 :
Yes
Epitope Location or Sequence :
I区域(氨基酸248-303)
表位定位Pubmed登录号 :
7642561
Recommended Applications :
FACS,Function Blocking,Immunofluorescence,Immunohistochemistry,Immunoprecipitation
Immunoblotting (legacy) :
No
免疫荧光PubMed IDs :
3514755 11714770
免疫沉淀PubMed IDs :
6984191 7608563 6196430
Function Blocking Pubmed IDs :
6984191 2477710 1723715 15023143 3514755 1967267 2681413 2398277 1594606 7608563 11714770
流式细胞仪PubMed IDs :
2681413 11313403 2477710 7608563 1834738
PubMed IDs :
2407741 14610042
DSHB增长培养基 :
RPMI
References (legacy) :
PNAS 79, 7489-7493
公司信息
Developmental Studies Hybridoma Bank
University of Iowa
dshb@uiowa.edu
http://dshb.biology.uiowa.edu
公司总部: 美国
Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构,为生命科学研究领域及诊断领域,提供高质量的抗体等产品。