产品简要
公司名称 :
Developmental Studies Hybridoma Bank
产品类型 :
抗体
产品名称 :
Notch1 intracellular domain (human)
目录 :
bTAN 20
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
bTAN 20
反应物种 :
人类, 小鼠, 犬
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
文章摘录数: 19
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类
Baldoni S, Del Papa B, Dorillo E, Aureli P, De Falco F, Rompietti C, et al. Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia. Int J Cancer. 2018;143:958-970 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2b
Fujiwara T, Zhou J, Ye S, Zhao H. RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell Death Dis. 2016;7:e2300 pubmed 出版商
Agabiti S, Li J, Dong W, Poe M, Wiemer A. Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition. Cell Death Dis. 2019;10:733 pubmed 出版商
Saha M, Mitsuhashi S, Jones M, Manko K, Reddy H, Bruels C, et al. Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. Hum Mol Genet. 2017;26:2984-3000 pubmed 出版商
Bauer L, Takacs A, Slotta Huspenina J, Langer R, Becker K, Novotny A, et al. Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study. Front Oncol. 2015;5:94 pubmed 出版商
Zhou J, Fujiwara T, Ye S, Li X, Zhao H. Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2. Calcif Tissue Int. 2015;96:465-75 pubmed 出版商
Kannan S, Sutphin R, Hall M, Golfman L, Fang W, Nolo R, et al. Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med. 2013;210:321-37 pubmed 出版商
Meliou E, Kerezoudis N, Tosios K, Kiaris H. Notch 1 Receptor, Delta 1 Ligand and HES 1 Transcription Factor are Expressed in the Lining Epithelium of Periapical Cysts (Preliminary Study). Open Dent J. 2010;4:153-8 pubmed 出版商
Watanabe K, Nagaoka T, Lee J, Bianco C, Gonzales M, Castro N, et al. Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1. J Cell Biol. 2009;187:343-53 pubmed 出版商
Fox V, Gokhale P, Walsh J, Matin M, Jones M, Andrews P. Cell-cell signaling through NOTCH regulates human embryonic stem cell proliferation. Stem Cells. 2008;26:715-23 pubmed
Shimizu T, Nakano K, Tsujigiwa H, Nagatsuka H, Watanabe T, Okafuji N, et al. Notch signaling in mandibular condylar cartilage development. Eur J Med Res. 2007;12:515-9 pubmed
Shimizu T, Tsujigiwa H, Nagatsuka H, Okafuji N, Kurihara S, Nagai N, et al. Expression of Notch1 and Math1 in mandibular condyle cartilage in neonatal mice. Angle Orthod. 2005;75:993-5 pubmed
Kawakami T, Shimizu T, Kimura A, Hasegawa H, Siar C, Ng K, et al. Immunohistochemical examination of cytological differentiation in osteosarcomas. Eur J Med Res. 2005;10:475-9 pubmed
Chappell W, Green T, Spengeman J, McCubrey J, Akula S, Bertrand F. Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1. Cell Cycle. 2005;4:1389-95 pubmed
Kawakami T, Siar C, Ng K, Shimizu T, Okafuji N, Kurihara S, et al. Expression of Notch in a case of osteosarcoma of the maxilla. Eur J Med Res. 2004;9:533-5 pubmed
Sade H, Krishna S, Sarin A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J Biol Chem. 2004;279:2937-44 pubmed
Jundt F, Anagnostopoulos I, Forster R, Mathas S, Stein H, Dorken B. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood. 2002;99:3398-403 pubmed
Blaumueller C, Qi H, Zagouras P, Artavanis Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell. 1997;90:281-91 pubmed
Zagouras P, Stifani S, Blaumueller C, Carcangiu M, Artavanis Tsakonas S. Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci U S A. 1995;92:6414-8 pubmed
产品信息
内部号码 :
409
名称 :
bTAN 20
Depositor Name :
Artavanis-Tsakonas, S.
Depositor Institution :
Harvard Medical School
Date Deposited :
5/2/00
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
抗原 :
Notch1 intracellular domain (human)
抗原物种 :
人类
宿主物种 :
大鼠
抗体亚型 :
RIgG1, kappa light chain
Isotype for catalog (legacy) :
IgG1, kappa light chain
Positive Tested Species Reactivity :
狗, 人类, 小鼠
Species Tested (legacy) :
人类, 小鼠, 狗
Initial Publication Pubmed ID :
7604005
Depositor Notes (Special Instructions) :
bTAN 20 doesn't work well for immunoprecipitation
Collections :
Cardiac development,Cell adhesion,Cell signaling,Human,Neurodevelopment,Skeletal muscle,Transcription factors
搜索关键词 :
Artavanis-Tsakonas, S., Notch1 intracellular domain (human), Human, RIgG1, kappa light chain, human/mouse/canine, NOTCH1, hN1, AOS5, TAN1, AOVD1, AB_2153497, monoclonal, Cardiac development/Cell adhesion/Cell signaling/Human/Transcription factors/Neurodevelopment/Skeletal muscle, Immunohistochemistry/Immunofluorescence/Western Blot
抗原分子量 :
Apparent: 300 kDa processed to give a major intracellular product of 110-120 kDa
基因 :
NOTCH1
Alternate Gene Name(s) :
hN1, AOS5, TAN1, AOVD1
UniProt数据库编号 :
P46531
抗体登记处号码 :
AB_2153497
Synonyms (Alternate Clone Names) :
15A
免疫原 :
Recombinant fusion protein GST-Notch1 intrcellular domain
免疫原序列 :
Partial protein
克隆性 :
单克隆
Myeloma Strain :
P3X63Ag8.653(ATCC CRL-1580)
表位定位 :
Yes
Epitope Location or Sequence :
intracellular domain
表位定位Pubmed登录号 :
7604005
Recommended Applications :
免疫荧光, 免疫组化, 免疫印迹
Immunoblotting (legacy) :
Excellent
免疫组化PubMed IDs :
7604005 15649865 16354601 16448243 18024259 21116324 11964309
免疫荧光PubMed IDs :
7604005 18055449 28498977 25712254
免疫印迹PubMed IDs :
7604005 9244302 11964309 14583609 16096376 18055449 28498977
DSHB增长培养基 :
RPMI
References (legacy) :
Proc. Natl. Acad. Sci. 92, 6414-6418.; Cell 90, 281-291.; Eur. J. Med. Res. 9, 533-535.; Eur. J. Med. Res. 10, 475-479.; Angle Orthod. 75(6), 993-995.; Eur. J. Med. Res. 12, 515-519.; Open Dent. J. 4, 153-158.
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
公司信息
Developmental Studies Hybridoma Bank
University of Iowa
dshb@uiowa.edu
http://dshb.biology.uiowa.edu
公司总部: 美国
Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构，为生命科学研究领域及诊断领域，提供高质量的抗体等产品。