产品简要
公司名称 :
Dianova
产品类型 :
抗体
产品名称 :
Anti-CD8a (Ms) from Rat (Clone: GHH8) for mouse FFPE tissue
目录 :
DIA-808
规格 :
200微升
价格 :
345 EUR plus VAT
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
nonconjugated
克隆名称 :
GHH8
反应物种 :
小鼠
应用 :
免疫组化-石蜡切片
更多信息或购买 :
Dianova 产品网页
文章摘录数: 2
参考文献
Kuczynski E, Krueger J, Chow A, Xu P, Man S, Sundaravadanam Y, et al. Impact of chemical-induced mutational load increase on immune checkpoint therapy in poorly responsive murine tumors. Mol Cancer Ther. 2018;: pubmed 出版商
Wüstner S, Anderl F, Wanisch A, Sachs C, Steiger K, Nerlich A, et al. Helicobacter pylori ?-glutamyl transferase contributes to colonization and differential recruitment of T cells during persistence. Sci Rep. 2017;7:13636 pubmed 出版商
图像
图像 1 :
Dianova DIA-808 图像 1
The monoclonal antibody clone GHH8 specifically stains CD8a in standard formalin-fixed paraffin-embedded mouse spleen.
产品信息
目录代码 :
DIA-808
产品名称 :
Anti-CD8a (Ms) from Rat (Clone: GHH8) for mouse FFPE tissue
产品类型 :
抗体
宿主物种 :
大鼠
克隆性 :
单克隆
共轭 :
nonconjugated
克隆名称 :
GHH8
抗体亚型 :
IgG2a
照明链 :
kappa
规格 :
200微升
标价 :
345 EUR plus VAT
产品描述 :
Antibody clone GHH8 has been developed and validated for the detection of murine CD8a in formalin-fixed paraffin-embedded tissue sections (mouse FFPE). Clone GHH8 identifies cytotoxic and regulatory T-cells (also known as suppressor T-cells) in murine FFPE tissue by IHC.
交叉活性 :
does not cross react with human
背景 :
CD8 is a marker for T-cells with suppressor and cytotoxic activity. Cluster of Differentiation 8 (CD8) is also found on the surface of some natural killer cells, most thymocytes, some T-cell lymphomas and large granular lymphocyte leukemias. Antigen recognition and subsequent T-cell activation is controlled by the interaction between TCR (T-cell receptor) and pMHC (peptide-major histocompatibility complexe). T-cell activation is often enhanced by a close cooperation of the TCR with two different co-receptors: CD8 and CD4. CD8 was first discovered as a cell surface marker in mice and was used to discriminate CD8+ CTLs and CD4+ Th cells. CD8a is expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alpha alpha). CD8 alpha beta is expressed on the majority of cytotoxic T-lymphocytes (CTLs). This CD8 heteromeric proteins (with approx. 32-34 KDa each monomer) are physically associated with a p56 tyrosine kinase to mediate T-cell activation signals through phosphorylation of adjacent proteins. Besides its important role in T-cell signalling, the CD8 co-receptor is also important for CD8+ T-cell development, stabilisation of the interface between CD8+ T-cells and target cells, and activation of intestinal epithelial T lymphocytes (iIELs). Therefore, CD8 has been the target of many therapeutic strategies designed to modulate T-cell responses during auto-immune reactions, allergy and organ transplant rejection.
免疫原 :
合成肽,来自小鼠CD8a
特异性 :
小鼠CD8a
纯度 :
纯化
防腐剂 :
0.05% NaN3
浓度 :
0.5毫克/毫升
应用摘要 :
IHC-P;other not tested
更多信息或购买 :
Dianova 产品网页
公司信息
Dianova
Warburgstr. 45
D-20354 Hamburg
info@dianova.de
www.dianova.de
49 40 45 06 73 30
公司总部: 德国
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
In addition to distributing Life Science and Diagnostic Products in the German speaking region dianova manufactures and markets a series of antibodies with unique properties on a worldwide basis under the brand of optistain. To this end dianova has successfully established a distribution network in more than 25 countries.
At dianova quality is of paramount importance and subject to strict control. Internal controls and audits are carried out in addition to on-site inspections by independent, external inspection companies. In 2003 the TÜV Rheinland/Berlin/Brandenburg successfully completed the first comprehensive certification process. Since then dianova has been certified pursuant to the international DIN EN ISO 9001:2008 standard.