This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
磷酸酶张力蛋白同源基因抗体, 克隆6H2.1
目录 :
04-035
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
6H2.1

同一抗体克隆可从以下厂商购到:
  • 丹科医疗器械技术服务（上海）有限公司: M3627
  • 北京傲锐东源: AM10137SU-N
反应物种 :
人类, 小鼠
文章摘录数: 14
参考文献
Vuono E, Mukherjee A, Vierra D, Adroved M, Hodson C, Deans A, et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016;6:36439 pubmed 出版商
Høye A, Couchman J, Wewer U, Yoneda A. The Phosphorylation and Distribution of Cortactin Downstream of Integrin α9β1 Affects Cancer Cell Behaviour. Sci Rep. 2016;6:28529 pubmed 出版商
Tzani I, Ivanov I, Andreev D, Dmitriev R, Dean K, Baranov P, et al. Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoform. Open Biol. 2016;6: pubmed 出版商
Saeed M, Andreo U, Chung H, Espiritu C, Branch A, Silva J, et al. SEC14L2 enables pan-genotype HCV replication in cell culture. Nature. 2015;524:471-5 pubmed 出版商
Zhou W, Shao H, Zhang D, Dong J, Cheng W, Wang L, et al. PTEN signaling is required for the maintenance of spermatogonial stem cells in mouse, by regulating the expressions of PLZF and UTF1. Cell Biosci. 2015;5:42 pubmed 出版商
Li J, Tanhehco E, Russell B. Actin dynamics is rapidly regulated by the PTEN and PIP2 signaling pathways leading to myocyte hypertrophy. Am J Physiol Heart Circ Physiol. 2014;307:H1618-25 pubmed 出版商
Trietsch M, Spaans V, Ter Haar N, Osse E, Peters A, Gaarenstroom K, et al. CDKN2A(p16) and HRAS are frequently mutated in vulvar squamous cell carcinoma. Gynecol Oncol. 2014;135:149-55 pubmed 出版商
Perez García V, Redondo Muñoz J, Kumar A, Carrera A. Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity. Mol Cell Biol. 2014;34:3359-73 pubmed 出版商
Screen M, Jonson P, Raheem O, Palmio J, Laaksonen R, Lehtimaki T, et al. Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions. Am J Pathol. 2014;184:2322-32 pubmed 出版商
Park R, Chen J, Kim J, Jeong S, Ohn T. Splicing factor SRSF3 represses the translation of programmed cell death 4 mRNA by associating with the 5'-UTR region. Cell Death Differ. 2014;21:481-90 pubmed 出版商
Jones A, Teschendorff A, Li Q, Hayward J, Kannan A, Mould T, et al. Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. PLoS Med. 2013;10:e1001551 pubmed 出版商
ANASTASIO N, Gilbertson S, Bubar M, Agarkov A, Stutz S, Jeng Y, et al. Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior. J Neurosci. 2013;33:1615-30 pubmed 出版商
Li F, Shen L, Li Z, Luo H, Qiu M, Zhang H, et al. Impact of KRAS mutation and PTEN expression on cetuximab-treated colorectal cancer. World J Gastroenterol. 2010;16:5881-8 pubmed
Lobo G, Waite K, Planchon S, Romigh T, Nassif N, Eng C. Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function. Hum Mol Genet. 2009;18:2851-62 pubmed 出版商
产品信息
目录代码 :
04-035
亚类别 :
Cell Signaling
产品名称 :
抗磷酸酶张力蛋白同源基因抗体, 克隆6H2.1
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P60484;O08586(小鼠)
宿主名称 :
小鼠
抗原 :
磷酸酶张力蛋白同源基因
克隆 :
6H2.1
共轭标签 :
纯化
抗体亚型 :
IgG
产品描述 :
抗磷酸酶张力蛋白同源基因抗体, 克隆6H2.1
交叉活性 :
人类;小鼠;大鼠
背景 :
The protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, in conjunction with FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation, creating PI(3,4,5)P3. In cells lacking PTEN, there are elevated levels of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration.
免疫原 :
C-terminal 100 amino acids of PTEN
特异性 :
识别磷酸酶张力蛋白同源基因
包装尺寸 :
100微克
用途 :
免疫印迹;免疫沉淀;免疫组化(石蜡)
储存 :
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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