This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
公司名称 :
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
产品名称 :
抗HIF-1α抗体, 克隆EP1215Y, 兔单克隆
目录 :
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反应物种 :
人类, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
文章摘录数: 6
  • 免疫印迹; 人类; 图 1a
Alig S, Stampnik Y, Pircher J, Rotter R, Gaitzsch E, Ribeiro A, et al. The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1α (HIF-1α) protein levels in endothelial cells under hypoxia. PLoS ONE. 2015;10:e0121113 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:1000
Ramamoorthy P, Shi H. Ischemia induces different levels of hypoxia inducible factor-1? protein expression in interneurons and pyramidal neurons. Acta Neuropathol Commun. 2014;2:51 pubmed 出版商
Hoppe G, Lee T, Yoon S, Yu M, Peachey N, Rayborn M, et al. Inducing a visceral organ to protect a peripheral capillary bed: stabilizing hepatic HIF-1? prevents oxygen-induced retinopathy. Am J Pathol. 2014;184:1890-9 pubmed 出版商
Goetzenich A, Hatam N, Preuss S, Moza A, Bleilevens C, Roehl A, et al. The role of hypoxia-inducible factor-1? and vascular endothelial growth factor in late-phase preconditioning with xenon, isoflurane and levosimendan in rat cardiomyocytes. Interact Cardiovasc Thorac Surg. 2014;18:321-8 pubmed 出版商
Zhang Z, Yan J, Taheri S, Liu K, Shi H. Hypoxia-inducible factor 1 contributes to N-acetylcysteine's protection in stroke. Free Radic Biol Med. 2014;68:8-21 pubmed 出版商
Yan J, Zhou B, Taheri S, Shi H. Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke. PLoS ONE. 2011;6:e27798 pubmed 出版商
目录代码 :
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗HIF-1α抗体, 克隆EP1215Y, 兔单克隆
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产品描述 :
抗HIF-1α抗体, 克隆EP1215Y, 兔单克隆
交叉活性 :
背景 :
Hypoxia, a condition of low tissue O2 concentration, plays an important role in normal physiological processes and tumor formation. Under hypoxic conditions mammalian cells up regulate the expression of hypoxic genes, including induction of angiogenesis and a switch to anaerobic metabolism, in order to survive. HIF-1 (Hypoxia Inducible Factor-1) is one of the key regulators of the transcriptional response to oxygen deprivation (1). HIF-1 is composed of two subunits, HIF-1αand HIF-1β also known as aryl hydrocarbon receptor nuclear translocator (ARNT)) that are members of the basic helix-loop-helix (bHLH) Per-Arnt-Sim (PAS) (bHLH-PAS) family of transcription factors. HIF-1 is essential for angiogenesis, embryonic development, and is associated with tumor progression, erythropoiesis, vascular development/remodeling, vasodilation, and glucose/energy metabolism. The over expression of HIF-1αhas been demonstrated in many common human cancers including prostate and breast, in which HIF-1α levels are associated with increase vascularitry and tumor progression. Besides physiological hypoxia, genetic abnormalities frequently detected in human cancers, such as loss of function mutations (Von Hippel-Lindau, p53, and PTEN), are associated with induction of HIF1 activity and expression of HIF-1-inducible genes (1).
别名 :
ARNT interacting protein ;ARNT-interacting protein ;Basic-helix-loop-helix-PAS protein MOP1 ;HIF-1 alpha ;HIF1 alpha ;Member of PAS protein 1 ;hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) ;hypoxia-inducible factor 1, alpha subunit ;hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) ;member of PAS superfamily 1
免疫原 :
Synthetic peptide corresponding to residues near the C-terminus of human HIF-1α.
特异性 :
This antibody recognizes HIF-1α at and around the C-terminus.
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Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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