Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

RNA聚合酶II亚单位B1抗体, 克隆4F8

04-1569

100微克

单克隆

大鼠

未共轭

4F8

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 染色质免疫沉淀

Epigenetics & Nuclear Function

抗RNA聚合酶II亚单位B1抗体, 克隆4F8

抗体

单克隆抗体

P24928

大鼠

RNA聚合酶II亚单位B1

4F8

纯化

IgG1κ

抗RNA聚合酶II亚单位B1抗体, 克隆4F8

小鼠;人类

RNA polymerase II subunit B1 (RPB1) is the largest subunit of the RNA polymerase II complex. As a holoenzyme RNA polymerase II catalyzes transcription of eukaryotic DNA into RNA using the four ribonucleoside triphosphates as substrates. The RBP1 subunit, in combination with other polymerase subunits, forms a large central cleft that maintains contact between the active site of the enzyme, the DNA template, and the nascent RNA transcript. This subunit also contains a carboxy terminal domain (CTD) consisting of tandem heptapeptide repeats. In actively transcribing RNA polymerase ‘Ser-2’ and ‘Ser-5’ of the heptapeptide repeat are phosphorylated. Phosphorylation activates the RNA polymerase II beta subunit, allowing it to serve as an assembly platform for additional subunits that modulate initiation, elongation, termination and mRNA processing.

DNA-directed RNA polymerase II A;DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit;DNA-directed RNA polymerase II subunit A;DNA-directed RNA polymerase III largest subunit;RNA polymerase II subunit B1;RNA-directed RNA polymerase II subunit RPB1;polymerase (RNA) II (DNA directed) polypeptide A (220kD);polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Ovalbumin-conjugated linear peptide corresponding to human RNA polymerase II subunit B1.

这抗体识别RNA聚合酶II亚单位B1

100微克

免疫印迹;酶联免疫吸附测定;染色质免疫沉淀 (ChIP)

收到之日起在2-8℃稳定1年