Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

RNA polymerase II subunit B1 (phospho-CTD Ser-5) Antibody, clone 3E8

04-1572

100微克

单克隆

大鼠

未共轭

3E8

人类, 小鼠

Epigenetics & Nuclear Function

Anti-RNA polymerase II subunit B1 (phospho-CTD Ser-5) Antibody, clone 3E8

抗体

单克隆抗体

P24928

大鼠

RNA polymerase II subunit B1 (phospho-CTD Ser-5)

3E8

纯化

IgG2aκ

Anti-RNA polymerase II subunit B1 (phospho-CTD Ser-5) Antibody, clone 3E8

小鼠;人类

RNA polymerase II subunit B1 (RPB1) is the largest subunit of the RNA polymerase II complex. As a holoenzyme RNA polymerase II catalyzes transcription of eukaryotic DNA into RNA using the four ribonucleoside triphosphates as substrates. The RBP1 subunit, in combination with other polymerase subunits, forms a large central cleft that maintains contact between the active site of the enzyme, the DNA template, and the nascent RNA transcript. This subunit also contains a carboxy terminal domain (CTD) consisting of tandem heptapeptide repeats. Phosphorylation activates the RNA polymerase II beta subunit, allowing it to serve as an assembly platform for additional subunits that modulate initiation, elongation, termination and mRNA processing. In actively transcribing RNA polymerase ‘Ser-2’ and ‘Ser-5’ of the heptapeptide repeat are phosphorylated. Ser-7 is phosphorylated before initiation of transcription at promoter regions.

DNA-directed RNA polymerase II A;DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit;DNA-directed RNA polymerase II subunit A;DNA-directed RNA polymerase III largest subunit;RNA polymerase II subunit B1;RNA-directed RNA polymerase II subunit RPB1;polymerase (RNA) II (DNA directed) polypeptide A (220kD);polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Ovalbumin-conjugated linear peptide corrresponding to human RNA polymerase subunit B1 CTD phosphorylated at Ser5.

This antibody recognizes RNA polymerase II subunit B1 at the CTD when phosphorylated at Ser5.

100微克

染色质免疫沉淀 (ChIP);免疫印迹;酶联免疫吸附测定

收到之日起在2-8℃稳定1年