Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

磷脂酰肌醇(-3)激酶抗体, p85α兔单克隆

04-403

100微升

单克隆

domestic rabbit

未共轭

Cell Signaling

抗磷脂酰肌醇(-3)激酶抗体, p85α兔单克隆

抗体

单克隆抗体

P27986

兔

磷脂酰肌醇(-3)激酶

纯化

IgG

抗磷脂酰肌醇(-3)激酶抗体, p85α兔单克隆

人类;小鼠;大鼠

PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β:γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.

PI3-kinase p85 subunit alpha;PtdIns-3-kinase p85-alpha;phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha);phosphatidylinositol 3-kinase, regulatory, 1;phosphatidylinositol 3-kinase-associated p-85 alpha;phosphoinositide-3-kinase, regulatory subunit 1 (alpha);phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha);phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha).

KLH共轭标签合成多肽对应于C末端区域，人的磷脂酰肌醇(-3)激酶, p85α亚单位

This antibody recognizes the C-terminal domain of PI3 Kinase, p85α subunit.

100微升

流式细胞仪;免疫细胞化学;免疫荧光;免疫组化(石蜡);免疫沉淀;免疫印迹

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.