Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

monomethyl-Histone H4 (Lys20) Antibody, clone NL314, rabbit monoclonal

04-735

100微升

单克隆

domestic rabbit

未共轭

NL314

Epigenetics & Nuclear Function

Anti-monomethyl-Histone H4 (Lys20) Antibody, clone NL314, rabbit monoclonal

抗体

单克隆抗体

P62805

兔

monomethyl-Histone H4 (Lys20)

NL314

Culture Supernatant

IgG

Anti-monomethyl-Histone H4 (Lys20) Antibody, clone NL314, rabbit monoclonal

人类

Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Histones are modified post-translationally by the actions of enzymes in both the nucleus and cytoplasm. These modifications, which include acetylation, phosphorylation, methylation, and ubiquitin-ation, occur predominantly on the N-terminal and C-terminal tails that extend beyond the nucleosome core particle. Trimethylation of histone H4 on lys20 (H4-K20me3) selectively marks constitutive pericentromeric hetero-chromatin and imprinting control regions, while mono- and dimethylation are broadly distributed but principally enriched in euchromatin regions. Although the biological function of H4K20me remains poorly understood, studies suggest that H4-K20me2 is involved in the guidance of DNA repair proteins to DNA strand breaks, whereas H4K20me1 is associated with chromatin condensation processes. PR-Set7 (also known as SET8) specifically catalyzes monomethylation of H4K20me1.

H4K20me1;Histone H4 (mono methyl K20);histone 4, H4;histone H4;histone cluster 4, H4

KLH-conjugated, synthetic peptide containing the sequence …HR[mmK]V…, in which mmK corresponds to monomethyl-lysine at residue 20 of human histone H4.

Recognizes monomethyl-histone H4 (Lys20), Mr ~10kDa.

100微升

Western Blotting;Multiplexing

Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.