产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
磷酸化Akt1/PKBα(Ser473)抗体, 克隆SK703, 兔单克隆
目录 :
04-736
规格 :
100微升
克隆性 :
单克隆
宿主 :
共轭标签 :
未共轭
克隆名称 :
SK703
反应物种 :
人类, 小鼠, ,
应用 :
免疫印迹
更多信息或购买 :
文章摘录数: 2
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 图 2
Vallo S, Michaelis M, Gust K, Black P, Rothweiler F, Kvasnicka H, et al. Dasatinib enhances tumor growth in gemcitabine-resistant orthotopic bladder cancer xenografts. BMC Res Notes. 2016;9:454 pubmed
Loi M, Becherini P, Emionite L, Giacomini A, Cossu I, Destefanis E, et al. sTRAIL coupled to liposomes improves its pharmacokinetic profile and overcomes neuroblastoma tumour resistance in combination with Bortezomib. J Control Release. 2014;192:157-66 pubmed 出版商
产品信息
目录代码 :
04-736
亚类别 :
Cell Signaling
产品名称 :
抗磷酸化Akt1/PKBα(Ser473)抗体, 克隆SK703, 兔单克隆
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P31749
宿主名称 :
抗原 :
磷酸化Akt1/PKBα(Ser473)
克隆 :
SK703
共轭标签 :
纯化
抗体亚型 :
IgG
产品描述 :
抗磷酸化Akt1/PKBα(Ser473)抗体, 克隆SK703, 兔单克隆
交叉活性 :
人类;小鼠
背景 :
The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKBα or RacPK), Akt2 (also designated PKB-β or RacPK-β) and Akt3 (also designated PKB-γ or thyoma viral proto-oncogene 3). Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-β tyrosine residues 740 and 751, which bind the 85 kDa subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generate a high level of Akt1 activity, and the phosphorylation of Thr 308 is not dependent on phosphorylation of Ser 473 in vivo. Thus, Akt proteins become phosphorylated and activated in insulin/IGF-1- stimulated cells by an upstream kinase(s). The activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin. Taken together, this data strongly suggests that the protein signals downstream of the PI kinases.
别名 :
AKT1 kinase;Protein kinase B;RAC-alpha serine/threonine-protein kinase ;rac protein kinase alpha ;v-akt murine thymoma viral oncogene homolog 1
免疫原 :
Peptide containing a pSer that corresponds to amino acid position 473 of human Akt1/PKBa
特异性 :
Recognizes phosphorylated Akt1/PKBα, Mr 60 kDa. Cross-reactivity to phosphorylated Akt2 and Akt3 likely based on sequence homology.
包装尺寸 :
100微升
用途 :
西方墨点法
储存 :
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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