产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Estrogen Receptor α Antibody, clone 60C, rabbit monoclonal
目录 :
04-820
规格 :
100微升
克隆性 :
单克隆
宿主 :
共轭标签 :
nonconjugated
克隆名称 :
60C
反应物种 :
人类, 小鼠,
应用 :
免疫印迹, 免疫沉淀
更多信息或购买 :
文章摘录数: 5
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 图 2a; 2g
Ladd B, Mazzola A, Bihani T, Lai Z, BRADFORD J, Collins M, et al. Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations. Oncotarget. 2016;7:54120-54136 pubmed 出版商
Bolt M, Stossi F, Callison A, Mancini M, Dandekar R, Mancini M. Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-? protein levels and activity. Oncogene. 2015;34:154-64 pubmed 出版商
Lee J, Tiwari A, Shum V, Mills G, Mancini M, Igoshin O, et al. Unraveling the regulatory connections between two controllers of breast cancer cell fate. Nucleic Acids Res. 2014;42:6839-49 pubmed 出版商
Bolt M, Stossi F, Newberg J, Orjalo A, Johansson H, Mancini M. Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses. Nucleic Acids Res. 2013;41:4036-48 pubmed 出版商
Poulard C, Treilleux I, Lavergne E, Bouchekioua Bouzaghou K, Goddard Leon S, Chabaud S, et al. Activation of rapid oestrogen signalling in aggressive human breast cancers. EMBO Mol Med. 2012;4:1200-13 pubmed 出版商
产品信息
目录代码 :
04-820
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
Anti-Estrogen Receptor α Antibody, clone 60C, rabbit monoclonal
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P03372
宿主名称 :
抗原 :
Estrogen Receptor α
克隆 :
60C
共轭标签 :
Culture Supernatant
抗体亚型 :
IgG
产品描述 :
Anti-Estrogen Receptor α Antibody, clone 60C, rabbit monoclonal
交叉活性 :
人类;小鼠;大鼠;牛;猪
背景 :
The Estrogen Receptors (ER) belong to the nuclear receptor family that contains a ligand-binding domain that maintains the protein in an inactive conformation unless bound to the hormone. Two ERs are known, ERα, classically known as ER, and ERβ, described long after ERα. Activated Estrogen Receptor is a DNA-binding protein capable of inducing many changes in gene expression. The Estrogen Receptor is believed to play an important role in the growth and development of a subset of hormone dependent human breast cancers. ERβ is expressed in prostate, ovary, and other reproductive organs. Although its steroid specificity is very similar to that of the ERα, the molecular mechanisms regulating the transcriptional activity of ERβ may be distinct from those regulating ERα.
别名 :
Estradiol receptor;Nuclear receptor subfamily 3 group A member 1;estrogen receptor 1;estrogen receptor alpha ;oestrogen receptor ;steroid hormone receptor
免疫原 :
KLH-conjugated, synthetic peptide corresponding to amino acids 13-32 (C-ALLHQIQGNELEPLNRPQLK) of human Estrogen Receptor α. The immunizing sequence is identical in rat and mouse and has 19/20 identical amino acids in bovine and porcine.
特异性 :
Recognizes Estrogen Receptor α. No cross-reactivity with Estrogen Receptor β.
包装尺寸 :
100微升
用途 :
免疫印迹;免疫沉淀
储存 :
Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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