Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

FOXP3抗体, 克隆3G3

04-960

100微克

单克隆

小鼠

未共轭

3G3

同一抗体克隆可从以下厂商购到:

• 北京傲锐东源: AM12131PU-N, TA336416
• Novus Biologicals: NBP2-33297, NB100-56582
• 亚诺法生技股份有限公司: MAB9852, MAB0107
• 圣克鲁斯生物技术: sc-52899
• 赛默飞世尔: MA5-18160, MA1-10332, MA5-16224, MA5-18159, MA1-41628, A18662, A18690, MA5-16222
• Tonbo Biosciences: 35-5773
• Exbio: A4-601-C100, A4-601-C025, A6-601-C025, 1P-601-C100, 11-601-C100, A6-601-C100, 1A-601-C100, 1A-601-C025, 1P-601-C025, 11-601-C025
• LifeSpan Biosciences: LS-C112622, LS-C368324, LS-C148080, LS-C112621, LS-C47269
• 西格玛奥德里奇: SAB4700611, SAB4700610

人类, 小鼠

炎症&免疫学

抗FOXP3抗体, 克隆3G3

抗体

单克隆抗体

Q99JB6

小鼠

FOXP3

纯化

IgG1κ

抗FOXP3抗体, 克隆3G3

小鼠;人类

The regulation of tolerance to self-antigens is a necessary biological process in order to prevent autoimmunity. CD4+ CD25+ regulatory T cells are known regulators of immune tolerance and activation. In both human and mice species, CD4+ CD25+ regulatory T cells are consistent in their expression of the transcription factor FOXP3 (forkhead box P3). FOXP3 acts as the “master switch” for the function and development of regulatory T cells. Mutations and deletions in the sequence encoding for FOXP3 expression lead to an inability to express FOXP3, causing an inability to regulate T cell development and leading to fatal autoimmune diseases such as IPEX and XLAAD. Conversely, recent studies have shown high and wide expression of FOXP3 in several cancer cell lines and tumors, indicating that FOXP3 is involved in preventing immunity against malignant tumors.

forkhead box P3;immune dysregulation, polyendocrinopathy, enteropathy, X-linked;immunodeficiency, polyendocrinopathy, enteropathy, X-linked

Histadine-tagged recombinant protein corresponding to the N-terminus of mouse FOXP3.

This antibody recognizes the N-terminus of Forkhead box protein P3 (FOXP3).

100微克

流式细胞仪;酶联免疫吸附测定

收到之日起在2-8℃稳定1年