This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
phospho-Akt (Ser473) Antibody, clone 6F5
目录 :
05-1003
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
6F5
反应物种 :
人类, 小鼠
文章摘录数: 7
参考文献 |
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Wang F, Yang L, Shi L, Li Q, Zhang G, Wu J, et al. Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells. Oncotarget. 2015;6:21468-78 pubmed
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产品信息
目录代码 :
05-1003
亚类别 :
Cell Signaling
产品名称 :
Anti-phospho-Akt (Ser473) Antibody, clone 6F5
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P31749
宿主名称 :
小鼠
抗原 :
phospho-Akt (Ser473)
克隆 :
6F5
共轭标签 :
纯化
抗体亚型 :
IgG1κ
产品描述 :
Anti-phospho-Akt (Ser473) Antibody, clone 6F5
交叉活性 :
人类;小鼠;大鼠;脊椎动物
背景 :
Akt/PKB is a Ser/Thr kinase and a major known effecter of the PI3 Kinase pathway. It is involved in multiple signaling pathways that relate to many biological processes including glucose metabolism, cell survival/apoptosis, cell cycle control, angiogenesis, differentiation, and cell growth and proliferation. In mammals three isoforms of Akt (Akt1/PKB, Akt2/PKB, and Akt3/PKB)exists. They exhibit a high degree of homology, but differ slightly in the localization of their regulatory phosphorylation sites. Akt is the predominant isoform that is in most tissues and is thought to have a dominant role in growth, survival, embryonic development, and adipocyte differentiation. Akt2 is correlated with the regulation of glucose homeostasis and is the predominant isoform expressed in insulin-responsive tissues. Akt3 is abundant in brain tissue. Each Akt isoform is composed of three functionally distinct regions: an N-terminal Pleckstrin Homology (PH) domain that provides a lipid-binding module to direct Akt to PIP3 at the cell membrane that is necessary for its activation, a central catalytic domain containing Thr308, and a C-terminal hydrophobic motif containing Ser473. The activation of Akt is dependent on a dual regulatory mechanism that requires both its translocation to the plasma membrane and dual phosphorylation on Thr308 and Ser473 by PDK1 and the TORC2 complex, respectively.
别名 :
Protein kinase B;RAC-alpha serine/threonine-protein kinase;murine thymoma viral (v-akt) oncogene homolog-1;rac protein kinase alpha;v-akt murine thymoma viral oncogene homolog 1
免疫原 :
Peptide encompassing and including phosphorylated Ser473 of human Akt1.
特异性 :
Recognizes Akt only when phosphorylated on Ser473. This antibody does not cross-react with Akt1/PKBα when it is not phosphorylated on Ser473.
包装尺寸 :
100微克
用途 :
酶联免疫吸附测定;免疫印迹;流式细胞仪;免疫荧光;免疫组化
储存 :
Stable for 1 year at 2-8ºC from date of receipt.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany
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