This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
phospho-Akt (Ser473) Antibody, clone 6F5
目录 :
05-1003
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
6F5
反应物种 :
人类, 小鼠
文章摘录数: 7
参考文献
Castella B, Kopecka J, Sciancalepore P, Mandili G, Foglietta M, Mitro N, et al. The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. Nat Commun. 2017;8:15663 pubmed 出版商
Kuo W, Hwu L, Wu C, Lee J, Chang C, Liu R. STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer. Theranostics. 2017;7:647-663 pubmed 出版商
Miyamoto Y, Torii T, Takada S, Ohno N, Saitoh Y, Nakamura K, et al. Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination. Mol Biol Cell. 2015;26:3489-503 pubmed 出版商
WILLIAMS K, KILLEBREW D, Clary G, Seawell J, Meeker R. Differential regulation of macrophage phenotype by mature and pro-nerve growth factor. J Neuroimmunol. 2015;285:76-93 pubmed 出版商
Wang F, Yang L, Shi L, Li Q, Zhang G, Wu J, et al. Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells. Oncotarget. 2015;6:21468-78 pubmed
Li X, Li J, Wilson A, Sipple J, Schick J, Pang Q. Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance. J Biol Chem. 2015;290:2715-27 pubmed 出版商
Cox S. Intracellular signaling of CTLs. Methods Mol Biol. 2014;1186:49-63 pubmed 出版商
产品信息
目录代码 :
05-1003
亚类别 :
Cell Signaling
产品名称 :
Anti-phospho-Akt (Ser473) Antibody, clone 6F5
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P31749
宿主名称 :
小鼠
抗原 :
phospho-Akt (Ser473)
克隆 :
6F5
共轭标签 :
纯化
抗体亚型 :
IgG1κ
产品描述 :
Anti-phospho-Akt (Ser473) Antibody, clone 6F5
交叉活性 :
人类;小鼠;大鼠;脊椎动物
背景 :
Akt/PKB is a Ser/Thr kinase and a major known effecter of the PI3 Kinase pathway. It is involved in multiple signaling pathways that relate to many biological processes including glucose metabolism, cell survival/apoptosis, cell cycle control, angiogenesis, differentiation, and cell growth and proliferation. In mammals three isoforms of Akt (Akt1/PKB, Akt2/PKB, and Akt3/PKB)exists. They exhibit a high degree of homology, but differ slightly in the localization of their regulatory phosphorylation sites. Akt is the predominant isoform that is in most tissues and is thought to have a dominant role in growth, survival, embryonic development, and adipocyte differentiation. Akt2 is correlated with the regulation of glucose homeostasis and is the predominant isoform expressed in insulin-responsive tissues. Akt3 is abundant in brain tissue. Each Akt isoform is composed of three functionally distinct regions: an N-terminal Pleckstrin Homology (PH) domain that provides a lipid-binding module to direct Akt to PIP3 at the cell membrane that is necessary for its activation, a central catalytic domain containing Thr308, and a C-terminal hydrophobic motif containing Ser473. The activation of Akt is dependent on a dual regulatory mechanism that requires both its translocation to the plasma membrane and dual phosphorylation on Thr308 and Ser473 by PDK1 and the TORC2 complex, respectively.
别名 :
Protein kinase B;RAC-alpha serine/threonine-protein kinase;murine thymoma viral (v-akt) oncogene homolog-1;rac protein kinase alpha;v-akt murine thymoma viral oncogene homolog 1
免疫原 :
Peptide encompassing and including phosphorylated Ser473 of human Akt1.
特异性 :
Recognizes Akt only when phosphorylated on Ser473. This antibody does not cross-react with Akt1/PKBα when it is not phosphorylated on Ser473.
包装尺寸 :
100微克
用途 :
酶联免疫吸附测定;免疫印迹;流式细胞仪;免疫荧光;免疫组化
储存 :
Stable for 1 year at 2-8ºC from date of receipt.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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