This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
表皮生长因子受体抗体, 克隆LA22
目录 :
05-104
规格 :
250微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
LA22
反应物种 :
人类
文章摘录数: 9
参考文献
Larsen M, Pérez Verdaguer M, Schmidt B, Bruchez M, Watkins S, Sorkin A. Generation of endogenous pH-sensitive EGF receptor and its application in high-throughput screening for proteins involved in clathrin-mediated endocytosis. elife. 2019;8: pubmed 出版商
Otsuki R, Yamamoto M, Matsumoto E, Iwamoto S, Sezutsu H, Suzui M, et al. Bioengineered silkworms with butterfly cytotoxin-modified silk glands produce sericin cocoons with a utility for a new biomaterial. Proc Natl Acad Sci U S A. 2017;114:6740-6745 pubmed 出版商
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed 出版商
Pasternack J, Domogauer J, Khullar A, Akudugu J, Howell R. The advantage of antibody cocktails for targeted alpha therapy depends on specific activity. J Nucl Med. 2014;55:2012-9 pubmed 出版商
De Santis R, Rosi A, Anastasi A, Chiapparino C, Albertoni C, Leoni B, et al. Efficacy of aerosol therapy of lung cancer correlates with EGFR paralysis induced by AvidinOX-anchored biotinylated Cetuximab. Oncotarget. 2014;5:9239-55 pubmed
Yu S, Liu H, Wang S, Chang C, Tsai C, Chao J. Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013;203:412-22 pubmed 出版商
Rogers K, Kikawa K, Mouradian M, Hernandez K, McKinnon K, Ahwah S, et al. Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association. Carcinogenesis. 2010;31:1523-30 pubmed 出版商
Duex J, Sorkin A. RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis. Mol Biol Cell. 2009;20:1833-44 pubmed 出版商
Deshmukh H, Case L, Wesselkamper S, Borchers M, Martin L, Shertzer H, et al. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am J Respir Crit Care Med. 2005;171:305-14 pubmed
产品信息
目录代码 :
05-104
亚类别 :
Cell Signaling
产品名称 :
抗表皮生长因子受体抗体, 克隆LA22
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P00533
宿主名称 :
小鼠
抗原 :
表皮生长因子受体
克隆 :
LA22
共轭标签 :
纯化
抗体亚型 :
IgG2a
产品描述 :
抗表皮生长因子受体抗体, 克隆LA22
交叉活性 :
人类
背景 :
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
别名 :
Receptor tyrosine-protein kinase ErbB-1;avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;cell growth inhibiting protein 40;cell proliferation-inducing protein 61;epidermal growth factor receptor;epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog);epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
免疫原 :
A431膜蛋白
特异性 :
Recognizes the sequence of Ala351-Asp364 of human EGF receptor, Mr 180kDa, (based on numbering without the signal peptide) (Wu et al., 1989).
包装尺寸 :
250微克
用途 :
免疫细胞化学;免疫沉淀;免疫印迹
储存 :
Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.