This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
EGFR (cytoplasmic domain) Antibody, clone 8G6.2
目录 :
05-1047
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
8G6.2
反应物种 :
人类, 小鼠
产品信息
目录代码 :
05-1047
亚类别 :
Cell Signaling
产品名称 :
Anti-EGFR (cytoplasmic domain) Antibody, clone 8G6.2
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P00533
宿主名称 :
小鼠
抗原 :
EGFR (cytoplasmic domain)
克隆 :
8G6.2
共轭标签 :
纯化
抗体亚型 :
IgG1κ
产品描述 :
Anti-EGFR (cytoplasmic domain) Antibody, clone 8G6.2
交叉活性 :
人类;小鼠;大鼠
背景 :
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFα). Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer. In addition to forming homodimers after ligand binding, EGFR may pair with another member of the ErbB receptor family, such as ErbB2/Her2/neu, to create an activated heterodimer. There is also evidence to suggest that clusters of activated EGFRs form, although it remains unclear whether this clustering is important for activation itself or occurs subsequent to activation of individual dimers. EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity. As a result, autophosphorylation of five tyrosine (Y) residues in the C-terminal domain of EGFR occurs. These are Y992, Y1045, Y1068, Y1148 and Y1173. This autophosphorylation elicits downstream activation and signaling by several other proteins that associate with the phosphorylated tyrosines through their own phosphotyrosine-binding SH2 domains. These downstream signaling proteins initiate several signal transduction cascades, principally the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. Such proteins modulate phenotypes such as cell migration, adhesion, and proliferation. The kinase domain of EGFR can also cross-phosphorylate tyrosine residues of other receptors it is aggregated with, and can itself be activated in that manner.
别名 :
Receptor tyrosine-protein kinase ErbB-1;avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;cell growth inhibiting protein 40;cell proliferation-inducing protein 61 ;epidermal growth factor receptor;epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog);epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
免疫原 :
Recombinant protein encoding the cytoplasmic domain (C-terminal) of human EGF Receptor.
特异性 :
This antibody detects the cytoplasmic domain of EGFR.
包装尺寸 :
100微克
用途 :
免疫细胞化学;免疫组化;免疫沉淀;免疫印迹
储存 :
Stable for 1 year at 2-8ºC from date of receipt.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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