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抗体

磷酸化黏着斑激酶(Tyr397)抗体, 克隆18

05-1140

100微克

单克隆

小鼠

未共轭

18

人类, 小鼠

Cell Structure

抗磷酸化黏着斑激酶(Tyr397)抗体, 克隆18

抗体

单克隆抗体

Q05397

小鼠

磷酸化黏着斑激酶(Tyr397)

18

纯化

IgG1

抗磷酸化黏着斑激酶(Tyr397)抗体, 克隆18

人类;小鼠

FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. FAK regulation includes phosphorylation at multiple tyrosine and serine residues. Phosphorylation of tyrosine generally is associated with positive regulation and growth promotion, however, dephosphorylation at these sites occurs as cells enter mitosis (M-Phase of the cell cycle). In contrast, serine phosphorylation either remains high or is increased as cells enter mitosis and may play a role in focal adhesion disassembly. Tyrosine 397 is the autophosphorylation site of Focal Adhesion Kinase. The site binds Src family SH2 domains and the p85 subunit of PI3-Kinase.

FADK 1;PTK2蛋白酪氨酸激酶2;蛋白酪氨酸激酶2;粘着激酶1

Generated from human FAK, a.a. 393-404, phosphorylated on Tyr397.

Reacts specifically with Focal Adhesion Kinase (FAK) when phosphorylated on Tyr397. FAK is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the "Focal Adhesion Targeting" sequence (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation at Tyr-397, and activation of FAK through phosphorylation of Tyr residues (Tyr-576 and Tyr577) in the kinase domain activation loop.

100微克

西方墨点法

Stable for 1 year at -20ºC from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.